山东大学耳鼻喉眼学报 ›› 2011, Vol. 25 ›› Issue (3): 58-61.

• 论文 • 上一篇    下一篇

IL-17在慢性鼻-鼻窦炎患者血浆中的表达及其意义

韩学锋,张磊,魏晓,李学忠   

  1. 山东大学齐鲁医院耳鼻咽喉-头颈外科, 济南 250012
  • 收稿日期:2011-03-28 修回日期:2011-05-02 出版日期:2011-06-16 发布日期:2011-06-16
  • 通讯作者: 李学忠(1964- ),男,医学博士,主任医师,教授,主要从事鼻科学的基础与临床研究工作。 Email: lxzebyh@163.com
  • 作者简介:韩学锋(1983- ),男,硕士研究生,主要从事鼻科学的研究工作。 Email:hl-doctor@163.com
  • 基金资助:

    山东省科技攻关项目(2010G0020236)。

The plasma levels of IL-17 and its significance in  chronic rhinosinusitis

HAN Xue-feng, ZHANG Lei, WEI Xiao, LI Xue-zhong   

  1. Department of Otolaryngology & Head and Neck Surgery, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2011-03-28 Revised:2011-05-02 Online:2011-06-16 Published:2011-06-16

摘要:

目的      本实验旨在研究IL-17在慢性鼻-鼻窦炎患者血浆中的表达情况,探讨其在慢性鼻-鼻窦炎发生发展中的影响机制。方法      收集伴有鼻息肉慢性鼻鼻窦炎患者38例(CRSwNP)、不伴有鼻息肉慢性鼻-鼻窦炎(CRSsNP)患者32例(柠檬酸钠抗凝)及对照组来自于门诊体检健康者28例的空腹晨血,采用ELISA法检测血浆中IL-17的含量。结果    正常对照组血浆IL-17的浓度为 1.6100(1.2575~1.9830)pg/mL ;慢性鼻-鼻窦炎组为8.2483(4.8868~10.1075) pg/mL; CRSwNP组为8.2430(6.2778~10.3610) pg/mL ; CRSsNP组为8.2550(4.8783~10.1650) pg/mL。IL-17在正常人与慢性鼻-鼻窦炎患者血浆中表达差异有统计学意义(P<0.05),但在CRSwNP 组与CRSsNP组差异无统计学意义。结论      慢性鼻-鼻窦炎患者血浆中IL-17明显高于正常人,推测其在慢性鼻-鼻窦炎的发生发展中起重要作用。

关键词: IL-17;慢性鼻-鼻窦炎;鼻息肉

Abstract:

Objective      To detect expression of IL-17 in the plasma of chronic rhinosinusitis patients, and to investigate the possible role of IL-17 in the mechanism of chronic rhinosinusitis. Methods     All the enrolled patients were divided into 3 groups: the chronic rhinosimusitis with nasal polyps (CRSwNP) group (38 cases), theCRSsNP group (32 cases), and the control group (28 cases). The plasma level of IL-17 was detected by ELISA. Results       ①  The plasma level of IL-17 was 1.6100(1.2575-1.9830) pg/mL in the control group, 8.2483(4.8868-10.1075) pg/mL in the chronic rhinosinusitis group, of which it was 8.2430(6.2778-10.3610) pg/mL in the CRSwNP group and 8.2550(4.8783-10.1650) pg/mL in the CRSsNP group. ②  A significant difference was found between the chronic rhino-sinusitis group and the control group(P<0.05). Expression of IL-17 in the CRSwNP and CRSsNP groups was significantly higher than that in the control group. However, there was no significant difference between the CRSwNP and CRSsNP groups in expression of IL-17. Conclusion     The plasma level of IL-17 in chronic rhino-sinusitis patients was significantly higher than that of normal people, suggesting that IL-17 might play an important role in the development of chronic rhinosinusitis.

Key words: IL-17; Chronic rhinosinusitis;Nasal polyps

中图分类号: 

  • R765.4
[1] 白永1,李娜2,赵慎林1,张旻1. 阿奇霉素对慢性鼻-鼻窦炎患者术腔黏膜中NF-kBp65IL-8表达的影响[J]. 山东大学耳鼻喉眼学报, 2012, 26(3): 40-44.
[2] 关娟. 以视功能障碍为主症的蝶窦囊肿治愈1例[J]. 山东大学耳鼻喉眼学报, 2012, 26(2): 93-94.
[3] 于春刚,岳凤枢. 上颌窦内壁巨大含牙囊肿1例[J]. 山东大学耳鼻喉眼学报, 2011, 25(4): 68-68.
[4] 高本西,王阳,杨凤山. 扁桃体腺样体切除治疗儿童鼻-鼻窦炎[J]. 山东大学耳鼻喉眼学报, 2009, 23(5): 41-42.
[5] 林炘 林歆胜 林佳伟 杨楚 李创伟. 鼻部横纹肌肉瘤12例临床分析[J]. 山东大学耳鼻喉眼学报, 2009, 23(4): 15-17.
[6] 刘婷婷 张念凯. 药物治疗慢性鼻-鼻窦炎嗅觉障碍的疗效观察[J]. 山东大学耳鼻喉眼学报, 2009, 23(4): 45-47.
[7] 顾真 宁云红 李艳 刘峰. 鼻窦清合剂对兔鼻窦炎上颌窦黏膜形态影响的电镜观察[J]. 山东大学耳鼻喉眼学报, 2009, 23(3): 39-42.
[8] 尤建强 巢长江 王晓晔 邱建鹤. 鼻内镜手术治疗额窦病变[J]. 山东大学耳鼻喉眼学报, 2009, 23(3): 45-47.
[9] 邓享坤1,李学忠2,邱志宏1,王金泉1,邓秀玉1,付丽华1. 892例慢性鼻-鼻窦炎患者内镜鼻窦手术围手术期临床分析[J]. 山东大学耳鼻喉眼学报, 2009, 23(6): 45-48.
[10] 韩飞, 崔新华, 古林涛, 王启荣. 功能性鼻内镜手术与鼻内镜下双径路手术治疗真菌性上颌窦炎的比较[J]. 山东大学耳鼻喉眼学报, 2009, 23(6): 49-50.
[11] 郑晓波1, 唐文伟1,韩素芳1, 林镝2. 16层螺旋CT低剂量扫描在儿童鼻窦检查中的应用[J]. 山东大学耳鼻喉眼学报, 2010, 24(6): 39-40.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!