三种不同给药途径治疗突发性感音神经性耳聋的效果对比

doi:10.6040/j.issn.1673-3770.0.2014.316

摘要/Abstract

摘要： 目的探讨治疗突发性感音神经性聋的最佳给药途径。方法将突发性感音神经性聋患者210例(213耳)分为静脉组70例(71耳), 给予静脉注射地塞米松;鼓膜穿刺组70例(71耳), 给予鼓室内注射甲强龙;耳后注射组70例(71耳), 给予耳后乳突区骨皮质下注射甲强龙。结果静脉组、鼓膜穿刺组、耳后注射组三组痊愈率、总有效率分别为29.58%、64.79%, 35.21%、80.28%, 64.79%、83.10%。三组痊愈率经统计学处理, 静脉组与鼓膜穿刺组差异无统计学意义(P>0.05), 静脉组与耳后注射组差异有统计学意义(P<0.01),鼓膜穿刺组与耳后注射组差异有统计学意义(P<0.01);总有效率静脉组与鼓膜穿刺组差异有统计学意义(P<0.05), 静脉组与耳后注射组差异有统计学意义(P<0.05), 鼓膜穿刺组与耳后注射组差异无统计学意义(P>0.05)。结论耳后乳突区骨皮质下注射甲强龙治疗突发性感音神经性聋痊愈率高, 总有效率稳定, 疗效确切, 方法简单, 易被患者接受。

关键词: 耳后注射, 鼓膜穿刺, 静脉, 突发性感音神经性聋, 糖皮质激素

Abstract: Objective To explore the best route of administration in the treatment of sudden sensorineural hearing loss. Methods According to the best route of administration. 210 sudden sensorineural hearing loss patients were divided into the venous group(70 patients injected dexamethasone via vein), the tympanic group(70 patients injected methylprednisolone into tympanic cavity), and the retroauricular group (70 patients injected methylprednisolone subperiosteally in the mastoid). Results The cure and effective rates of the three groups were 29.58%, 64.79%, 35.21%, 80.28%, and 64.79%, 83.10%, respectively. As for thecure rate,there were significant differences between the vein group and the retroauricular group(P<0.01), the tympanic group and the retroauricular group(P<0.01), but there were not significant differences between the vein group and the tympanic group(P>0.05). For the effective rates, there were significant differences between the vein group and the retroauricular group(P<0.01), the vein group and the tympanic group(P<0.01), but there were not significant differences between the tympanic group and the retroauricular group(P>0.05). Conclusion injecting methylprednisolone subperiosteally in the mastoid shows a high cure rate and stable effective rate sudden sensorineural hearing loss.

Key words: Eardrum puncture, Back ear injection, Sudden sensorineural hearing loss, Glucocorticoid, Vein

中图分类号:

R764.43

卢娜. 三种不同给药途径治疗突发性感音神经性耳聋的效果对比[J]. 山东大学耳鼻喉眼学报, 2015, 29(2): 24-27.

LU Na. Three different routes of administration in the treatment of sudden sensorineural hearing loss[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(2): 24-27.

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