D-二聚体与鼻咽癌预后的关系

doi:10.6040/j.issn.1673-3770.0.2015.150

山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (5): 47-49.doi: 10.6040/j.issn.1673-3770.0.2015.150

D-二聚体与鼻咽癌预后的关系

车娟¹, 赵洪春¹, 李金玲², 王延飞¹

1. 滨州医学院附属医院耳鼻咽喉科, 山东滨州 256603;
2. 滨州医学院附属医院检验科, 山东滨州 256603

收稿日期:2015-04-09 修回日期:2015-07-09 出版日期:2015-10-16 发布日期:2015-10-16
通讯作者: 王延飞,E-mail:cjbanana@163.com E-mail:cjbanana@163.com
作者简介:车娟,E-mail:13375438181@163.com

The relationship between D-Dimer and nasopharyngeal carcinoma

CHE Juan¹, ZHAO Hongchun¹, LI Jinling², WANG Yanfei¹

1. Department of Otolaryngology, the Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong, China;
2. Department of Laboratory Medicine, the Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong, China

Received:2015-04-09 Revised:2015-07-09 Online:2015-10-16 Published:2015-10-16

摘要/Abstract

摘要： 目的研究D-二聚体判断鼻咽癌预后的价值。方法 2009年1月至2012年12月前瞻性地比较了69例初诊鼻咽癌患者和69例健康个体就诊时的血浆D-二聚体水平,分析了鼻咽癌患者血浆D-二聚体水平与其临床分期的关系。采用受试者工作特征(ROC)曲线法和Kaplan-Meier法分析鼻咽癌患者D-二聚体与患者全因死亡率的关系。结果鼻咽癌患者血浆D-二聚体水平显著高于健康个体。随着鼻咽癌分期的递进,患者血浆D-二聚体水平逐渐增高。D-二聚体预测患者死亡的ROC曲线下面积为0.72。二聚体高于0.55 mg/L的患者全因死亡的风险明显高于D-二聚体低于0.55 mg/L的患者。结论 D-二聚体是鼻咽癌的预后指标,其增高提示患者预后不良。

关键词: 预后, D-二聚体, 鼻咽癌

Abstract: Objective To investigate the prognostic value of plasma D-dimer for nasopharyngeal carcinoma. Method Sixty-nine nasopharyngeal carcinoma patients and their gender-and age-matched healthy individuals were prospectively enrolled, and their plasma D-Dimer on admission were compared. The association between plasma D-Dimer and clinical stage of nasopharyngeal carcinoma was analyzed. The prognostic value of D-dimer for all-cause mortality was estimated by receiver operating characteristic (ROC) curves and Kaplan-Meier approach. Results Compared with healthy individuals, nasopharyngeal patients had significantly higher plasma D-dimer. Plasma D-Dimer increased as the advance of clinical stage of nasopharyngeal carcinoma. The area under ROC curve of plasma D-Dimer for all-cause mortality was 0.72. Patients with increased D-Dimer (more than 0.55 mg/L) have higher risk of death than the patients with normal D-Dimer (less than 0.55 mg/L). Conclusion D-Dimer is a useful prognostic factor for nasopharyngeal carcinoma. Increased D-Dimer is associated with poor prognosis.

Key words: D-Dimer, Prognosis, Nasopharyngeal carcinoma

中图分类号:

R766.3

车娟, 赵洪春, 李金玲, 王延飞. D-二聚体与鼻咽癌预后的关系[J]. 山东大学耳鼻喉眼学报, 2015, 29(5): 47-49.

CHE Juan, ZHAO Hongchun, LI Jinling, WANG Yanfei. The relationship between D-Dimer and nasopharyngeal carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(5): 47-49.

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D-二聚体与鼻咽癌预后的关系

The relationship between D-Dimer and nasopharyngeal carcinoma

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