咽喉部增生性病变相关发病因素分析

doi:10.6040/j.issn.1673-3770.0.2015.491

山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (3): 32-36.doi: 10.6040/j.issn.1673-3770.0.2015.491

咽喉部增生性病变相关发病因素分析

何桂军^1,2,钱晓云¹,顾亚军¹,林川耀¹,宋盼盼¹,高下¹

1.南京医科大学鼓楼临床医学院耳鼻咽喉头颈外科, 江苏南京 210000;
2.连云港市第二人民医院耳鼻咽喉头颈外科, 江苏连云港 222000

收稿日期:2015-11-18 出版日期:2016-06-16 发布日期:2016-06-16
通讯作者: 高下. E-mail:xiagaogao@hotmail.com E-mail:hgj2012000@163.co
作者简介:何桂军. E-mail:hgj2012000@163.co
基金资助:
南京市医学科技发展项目(YYK14062)

Analysis of the risk factors of proliferative laryngopharyngeal disease.

HE Guijun^1,2, QIAN Xiaoyun¹, GU Yajun¹, LIN Chuanyao¹, SONG Panpan¹, GAO Xia

1. Department of Otolaryngology &Head and Neck Surgery, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing 210000, Jiangsu, China;2. Lianyungang Second Peoples Hospital, Lianyungang 222000, Jiangsu, China

Received:2015-11-18 Online:2016-06-16 Published:2016-06-16

摘要/Abstract

摘要： 目的探讨影响咽喉部增生性病变发病的相关因素。方法收集门诊因咽喉部病变行电子喉镜检查及治疗的471例患者的一般情况、临床病理资料及反流症状指数(RSI)、反流体征评分(RFS)并进行统计学分析。结果吸烟、饮酒、RSI、RFS及胃病史与咽喉部是否出现增生性病变有相关性(P<0.05);而年龄、性别、体质量指数(BMI)与咽喉部是否出现增生性病变无明显相关性。年龄、性别、吸烟、饮酒及RFS与咽喉部增生性病变的性质有显著相关性(P<0.001);BMI与咽喉部增生性病变性质有相关性(P<0.05);RSI及胃病史则与之无关。Logistic回归分析发现,年龄、性别、吸烟、饮酒及RFS评分是咽喉部增生性病变的独立危险因素(P<0.05)。结论影响咽喉部是否出现增生性病变的主要因素是吸烟、饮酒、RSI、RFS及胃病史;增生物的良恶性则与年龄、性别、吸烟、饮酒、RFS及BMI相关。

关键词: 咽喉疾病, 反流症状指数(RSI), 反流体征评分(RFS), 病因

Abstract: Objective To investigate the risk factors of proliferative laryngopharyngeal disease(PLD). Methods A total of 471 patients with PLD were included in this retrospective study. Their general information, clinical data, reflux symptom index(RSI)and reflux fluiding score(RFS)were statistically analyzed. Results Smoking, alcohol, RSI, RFS and gastrosis were correlated with PLD(P<0.05), while age, sex and BMI were not correlated. Age, sex, smoking, alcohol and RFS score were significantly correlated with the nature of PLD(P<0.001), BMI was significantly correlated(P<0.05), while RSI score and gastrosis were not correlated. Logistic regression analysis indicated that age, gender, smoking, alcohol and RFS score were independent risk factors for the development of PLD(P<0.05). Conclusions The risk factors for PLD include smoking, alcohol, RSI, RFS and gastrosis. The benign or malignant nature of PLD is related to age, sex, smoking, alcohol, RFS and BMI.

Key words: Reverse fluid sign score, Etiology, Reflux symptom index, Pharyngolaryngeal disease

中图分类号:

R739.65

何桂军,钱晓云,顾亚军,林川耀,宋盼盼,高下. 咽喉部增生性病变相关发病因素分析[J]. 山东大学耳鼻喉眼学报, 2016, 30(3): 32-36.

HE Guijun, QIAN Xiaoyun, GU Yajun, LIN Chuanyao, SONG Panpan, GAO Xia. Analysis of the risk factors of proliferative laryngopharyngeal disease.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(3): 32-36.

参考文献

[1] Chen G, Ratcliffe J, Olds T, et al. BMI, health behaviors, and quality of life in children and adolescents: a school-based study[J]. Pediatrics, 2014, 133(4): e868-874.
[2] Caterina C, Gregorio C. Wine Consumption in the Mediterranean Diet: Old Concepts in a New Sight[J]. Food Nutrition Sci, 2012, 3(12):1726-1733.
[3] Kaplan M, Tanoglu A, Erkul E, et al. Association of reflux symptom index scores with gastroesophageal flap valve status[J]. Auris Nasus Larynx, 2014, 41(6):543-547.
[4] van der Pol R J, Singendonk M M, König A M, et al. Development of the reflux finding score for infants and its observer agreement[J]. J Pediatr, 2014, 165(3):479-484.
[5] Thirumazhisi Sachithanandam S. Rising Methicillin-Resistant Staphylococcus aureus Infections in Ear, Nose, and Throat Diseases[J]. Case Rep Otolaryngol, 2014: 253945.
[6] Xiao Y, Carson D, Boris L, et al. The acoustic cough monitoring and manometric profile of cough and throat clearing[J]. Dis Esophagus, 2014, 27(1):5-12.
[7] Nacci A, Fattori B, Basolo F, et al. Sex hormone receptors in vocal fold tissue: a theory about the influence of sex hormones in the larynx[J]. Folia Phoniatr Logop, 2011, 63(2):77-82.
[8] Kleemann D, Stengel B. The effect of hormonal agents on the development of chronic laryngitis and tumor disease. Report of two cases[J]. HNO, 2010, 58(3):305-312.
[9] Lu Y, Hajifathalian K, Ezzati M, et al. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants[J]. Lancet, 2014, 383(9921):970-983.
[10] Li N, Katzmarzyk P T, Horswell R, et al. BMI and coronary heart disease risk among low-income and underinsured diabetic patients[J]. Diabetes Care, 2014, 37(12):3204-3212.
[11] Spangler J, Csákányi Z, Rogers T, et al. Parental ease in asking others not to smoke and respiratory symptoms and illness among children[J]. Int J Environ Res Public Health, 2014, 11(2):1747-1755.
[12] Lourenço G J, Silva E F, Rinck-Junior J A, et al. tobacco and alcohol status and risk of head and necksquamous cell carcinoma[J]. Tumour Biol, 2011, 32(6):1209-1215.
[13] Jayalekshmi P A, Nandakumar A, Akiba S, et al. Associationsof tobacco use and alcohol drinking with laryngeal and hypopharyngeal cancer risks among men in Karunagappally, Kerala, India -Karunagappally cohort study[J]. PLoS One, 2013, 8(8):e73716.
[14] Lagergren J, Lindam A. Increased risk of laryngeal and pharyngeal cancer after gastrectomy for ulcer disease in a population-based cohort study[J]. Br J Cancer, 2012, 106(7):1342-1345.
[15] Weber C S, Kleinjung T. Common infections of the ear, nose, and throat[J]. Praxis, 2014, 103(17):1001-1007.
[16] Carruthers D G. TRACHEOTOMY-Diseases of the Ear, Nose, and Throat(Second Edition)-CHAPTER XXI[M]. Diseases of the Ear Nose & Throat, 2013:303-309.
[17] Mernelius S, Löfgren S, Lindgren P E, et al. The role of broth enrichment in Staphylococcus aureus cultivation and transmission from the throat to newborn infants: results from the Swedish hygiene intervention and transmission of S. aureus study[J]. Eur J Clin Microbiol Infect Dis, 2013, 32(12):1593-1598.
[18] Centor R M. Antibiotics for sore throat patients-varied opinions[J]. Scand J Infect Dis, 2013, 45(3):176-178.
[19] Ji Z H, Zu N. Research on acupuncture for throat diseases in Qing Dynasty[J]. Zhongguo Zhen Jiu, 2012, 32(6):571-572.
[20] Altman K W, Prufer N, Vaezi M F. A review of clinical practice guidelines for reflux disease: toward creating a clinical protocol for the otolaryngologist[J]. Laryngoscope, 2011, 121(4):717-723.
[21] Raynal M, Ceruse P, Girard B, et al. Management of ear, nose, and throat diseases in district hospital centers in Madagascar[J]. Med Trop(Mars), 2010, 70(1):13-17.
[22] Coca-Pelaz A, Rodrigo J P, Takes R P, et al. Relationship between reflux and laryngeal cancer[J]. Head Neck, 2013, 35(12):1814-1818.
[23] Belafsky P C, Postma G N, Amin M R, et al. Symptoms and findings of laryngopharyngeal reflux[J]. Ear Nose Throat J, 2002, 81(2):10-13.

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咽喉部增生性病变相关发病因素分析

Analysis of the risk factors of proliferative laryngopharyngeal disease.

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