复方倍他米松联合盐酸利多卡因辅助治疗突发性聋的疗效观察

doi:10.6040/j.issn.1673-3770.0.2017.508

摘要/Abstract

摘要： 目的探讨复方倍他米松联合盐酸利多卡因耳后乳突骨膜下注射治疗突发性聋的疗效。方法对2015年5月至2017年5月间收治的基础治疗方案相同、资料完整的100例单耳伴耳鸣的突发性聋病例进行回顾性研究和统计学分析。按其在基础治疗基础上是否给予复方倍他米松联合盐酸利多卡因耳后乳突骨膜下注射分为注射组50例和非注射组50例。对比治疗前后患者纯音听阈曲线,取0.25~4 kHz听力平均值,对听力提高分贝数进行对比;同时对患者耳鸣改善情况进行对比。结果听力疗效:注射组治愈10 例(20% ),显效 20例(40%),有效13例(26%),无效7例(14%);非注射组治愈5例(10%),显效10例(20%),有效18例(36%),无效17例(34%);耳鸣疗效:注射组治愈10例(20%),有效15例(30%),无效25例(50%);非注射组治愈6例(12%),有效13例(26%),无效31例(62%)。结论复方倍他米松联合盐酸利多卡因耳后局部注射,对突发性聋患者听力改善具有临床意义。

关键词: 耳后注射, 复方倍他米松, 盐酸利多卡因, 聋, 突发性

Abstract: Objective To investigate the effect of postauricular mastoid subperiosteal injection with betamethasone and lidocaine hydrochloride for idiopathic sudden deafness. Methods A 100 cases of idiopathic sudden deafness with concomitant tinnitus reported at the Henan Province Peoples Hospital between May 2015 and May 2016 were retrospectively studied. These cases were divided into the injection group(50 cases)and non-injection group(50 cases). The pure tone audiometry thresholds across 0.25-4 kHz and tinnitus levels of patients were evaluated before and after treatment. Results Based on audiometry measurements, in the injection group, 10 cases(20%)were cured, 20(40%)showed good effect, 13(26%)showed moderate effect, and 7(14%)showed no effect, whereas in the non-injection group, 5 cases(10%)were cured, 10(20%)showed good effect, 18(36%)showed moderate effect, and 17(34%)showed no effect. Tinnitus evaluation indicated that, in the injection group, 10 cases(20%)were cured, 15(30%)showed good effect, and 25(50%)showed no effect, whereas in the non-injection group, 6 cases(12%)were cured, 13(26%)showed good effect, and 31(62%)showed no effect. Conclusion The study found that postauricular mastoid subperiosteal injection with betamethasone and lidocaine hydrochloride was beneficial for patients with idiopathic sudden deafness.

Key words: Ears after injection, Deafness, sudden, Compound betamethasone, Lidocaine hydrochloride

中图分类号:

R764

黄颖铭,万保罗,靳钰炜. 复方倍他米松联合盐酸利多卡因辅助治疗突发性聋的疗效观察[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 11-13.

HUANG Yingming, WAN Baoluo, JIN Yuwei. Clinical efficacy of postauricular mastoid subperiosteal injection with betamethasone and lidocaine hydrochloride[J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 11-13.

参考文献

[1] 中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会. 突发性耳聋诊断和治疗指南(2015)[J].中华耳鼻咽喉头颈外科杂志,2015,50(6):443-447.
[2] 彭玉成,符涛,孙爱华,等. 弥可保和维生素B₁₂穴位注射治疗神经性耳鸣疗效观察[J].中国中西医结合耳鼻咽喉科杂志,2001,9(5):217. PENG Yucheng, FU Tao, SUN Aihua, et al. A comparative study on the therapeutic effect of acupoint injection to neurogenic tinnitus with methycobal[J]. Chin J Otorhinolaryngol Integr Med, 2001, 9(5):217.
[3] 李玲,黄志纯,陶锋. 突发性耳聋治疗及预后相关因素的研究进展[J]. 东南大学学报(医学版),2013,32(3):350-353.
[4] 杨晓琦,余力生,马鑫. 耳后注射复方倍他米松治疗顽固性低频型感音神经性聋[J].中华耳鼻咽喉头颈外科杂志,2007(42):814-815. YANG Xiaoqi, YU Lisheng, MA Xin. Postaurical injection of compound betamethasone to treat the intractable low-frequency sensorineural hearing loss[J]. Chin J Otorhinolaryngol Head Neck Surg, 2007(42):814-815.
[5] 李媚. 复方倍他米松联合山莨菪碱治疗突发性耳聋的疗效观察与护理[J].中国误诊学杂志,2014,11(11):2552.
[6] Jun HJ, Chang J, Im GJ, et al. Analysis of frequency loss as a prognostic factor in idiopathic sensorineural hearing loss[J]. Acta Otolaryngol, 2012,4(12):1-7.
[7] Morris L, Collins M. A patient with unilateral idiopathic sudden sensorineural hearing loss[J]. JAAPA, 2013, 26(1):32,34-35.
[8] 吴小娟,李和. 辅以利多卡因的穴位注射治疗主观性耳鸣临床观察[J]. 四川中医,2017,35(8):189-191.
[9] 王薇,黄鹤年. 利多卡因治疗耳鸣[J].国外医学耳鼻咽喉科学分册,1985,9(3):117.
[10] Noushi F, Richardson RT, Hardman J, et al. Dedlivery of neurotrophin-3 to the cochlea using alginate beads[J]. Otol Neurotol, 2005, 26(3):528-533.
[11] Endo T, Nakagawa T, Kita T, et al. Novel strategy for treatment of inner ears using a biodegradable gel[J]. Laryngoscope, 2005, 115(11):2016-2020.
[12] Li J, Yu L, Xia R, et al. Postauricular hypodermic injection to treat inner ear disorders: experimental feasibility study using magnetic resonance imaging and pharmacokinetic comparison[J]. J Laryngol Otol, 2013, 127(3):239-245.

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