运脾化痰通窍方治疗小儿鼾症及相应免疫功能变化

doi:10.6040/j.issn.1673-3770.0.2018.307

摘要/Abstract

摘要： 目的探讨姜之炎教授“运脾化痰通窍方”治疗小儿鼾症的临床效果及对免疫功能的影响。方法选择鼾症儿童60例,采用随机数字表法将其分为对照组和观察组各30例,对照组采用手术切除,观察组采用运脾化痰通窍方,疗程为3个月;比较2个组患儿治疗前后扁桃体大小、中医证候积分和临床有效率;免疫功能采用ELISA法检测外周静脉血免疫球蛋白IgA、IgG和IgM水平。结果两个组治疗后扁桃体明显缩小,对照组明显小于观察组(P<0.05),但观察组在正常范围。两组治疗后中医证候积分均明显降低,组间比较差异无统计学意义(P>0.05)。两组有效率比较差异无统计学意义(P>0.05)。对照组、观察组治疗后血清IgA、IgG和IgM水平较治疗前均无变化;治疗后观察组明显高于对照组,差异有统计学意义(P<0.05)。结论 “运脾化痰通窍方”与手术治疗小儿鼾症可取得理想的临床效果,不影响免疫功能,有较好的推广应用价值。

关键词: 运脾化痰通窍方, 手术, 鼾症, 中医证候, 免疫功能

Abstract: Objective To study the clinical effect of activating spleen treatment of nasal prescription on pediatric snoring disease and immune function. Methods Sixty consecutive subjects with pediatric snoring disease were enrolled from May 2016 to December 2017 and divided randomly into control and observation groups, each group comprising of 30 cases. Patients in the control group underwent resective surgery and those in the observation group were administered activating spleen treatment of nasal prescription. The total duration of treatment was 3 months, following which the difference in size of the tonsils were assessed. TCM syndrome scores, the clinical efficacy rate before and after treatment in the two groups, and immunologic parameters including IgA, IgG, and IgM levels in peripheral venous blood were evaluated by ELISA. Results The size of the tonsils was smaller in both groups after treatment with significant reduction in size being observed in the control group(P<0.05). The size of the tonsils was within the normal range in the observation group. Lower post-treatment TCM syndrome scores were observed in the two groups with no statistically significant difference(P>0.05). The efficacy rate was not significantly different between the two groups(P>0.05). Post-treatment, the levels of IgA, IgG, and IgM remained unchanged in the two groups(P>0.05). Conclusion Both treatments, nasal prescription for activation of spleen and resective surgery, can provide comparable clinical effect in cases of pediatric adenoidal hypertrophy with no effect on immune function.

Key words: Yunpi Huatan Tongqiao decoction, Surgery, Snoring disease, TCM syndrome, Immunologic function

中图分类号:

R272

于阅尽,顾静雯,黄卫,李佩,胡华,郝亚楠,樊永将,高轶昳. 运脾化痰通窍方治疗小儿鼾症及相应免疫功能变化[J]. 山东大学耳鼻喉眼学报, 2018, 32(6): 56-59.

YU Yuejin, GU Jingwen, HUANG Wei, LI Pei, HU Hua, HAO Yanan, FAN Yongjiang, GAO Yiyi. Clinical effect of Yunpi Huatan Tongqiao decoction on pediatric snoring disease and immune function[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(6): 56-59.

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