山东大学耳鼻喉眼学报 ›› 2020, Vol. 34 ›› Issue (1): 33-37.doi: 10.6040/j.issn.1673-3770.0.2019.510

• 论著 • 上一篇    下一篇

影响低频下降型突发性聋不伴眩晕预后的相关因素分析

宗小芳,胡国华,钟时勋,雷艳,江黎珠,康厚墉   

  1. 重庆医科大学附属第一医院 耳鼻咽喉科, 重庆 400016
  • 发布日期:2020-03-06
  • 通讯作者: 康厚墉. E-mail:1329547998@qq.com

Analysis of the factors affecting the prognosis of low-frequency descending sudden hearing loss without vertigo

ZONG Xiaofang, HU Guohua, ZHONG Shixun, LEI Yan, JIANG Lizhu, KANG Houyong   

  1. Department of Otorhinolaryngology, First Affiliateted Hospital of Chongqing Medical University, Chongqing 400016, China
  • Published:2020-03-06

摘要: 目的 分析相关因素对低频下降型突发性聋不伴眩晕预后的影响。 方法 共搜集符合纳入标准的低频下降型突发性聋106例的临床资料,分析性别、年龄、侧别、病程、伴随症状、听力损失程度与治疗效果之间的相关性。 结果 低频下降型突发性聋的总有效率79%,年龄≤30岁者治疗的总有效率最高(91%,31/34),高于31~45岁组(80%,37/46)和46~68岁组(61%,16/26),差异有统计学意义(P<0.05);病程≤7 d者(95%,52/55)预后要好于病程>7 d者(63%,32/51),差异有统计学意义(P<0.001);伴有耳闷者治疗效果(88%,53/60)优于不伴有耳闷者(37%,31/46),差异有统计学意义(P<0.05)。性别、发病侧别、是否伴有耳鸣、听力损失为轻度或中度,各组之间总有效率差异无统计学意义(P>0.05)。 结论 不伴眩晕的低频下降型突发性聋的预后与年龄、病程、是否耳闷及初始听力水平有关,与性别、侧别、是否伴耳鸣无关;年龄小、病程短、伴耳闷是不伴眩晕的低频下降型突发性聋预后良好的正性因素。

关键词: 低频下降型, 突发性聋, 预后

Abstract: Objective To analyze the effect of related factors on the prognosis of low-frequency descending sudden hearing loss without vertigo. Methods A total of 106 cases of low-frequency descending sudden hearing loss meeting the inclusion criteria were collected. The correlation between gender, age, side, course of the disease, concomitant symptoms, degree of hearing loss and therapeutic effect were analyzed. Results The total effective rate of low-frequency descending sudden hearing loss was 79%. The total effective rate was higher in patients aged ≤30 years old(91%, 31/34), compared to patients between 31 and 45 years old(80%, 37/46)and between 46 and 68 years old(61%, 16/26). The difference was statistically significant(p<0.05). Patients with a course ≤7 days(95%, 52/55)had a better prognosis than those with a course > 7 days(63%, 32/51), with this having a statistically significant difference(p<0.001). The therapeutic effect of patients with ear fullness(88%, 53/60)was better than those without ear fullness(37%, 31/46), and this difference was statistically significant(p<0.05).There was no statistically significant difference in the total effective rate between genders, incidence sides, whether they had tinnitus, or mild or moderate hearing loss(p>0.05). Conclusion The prognosis of low-frequency descending sudden hearing loss without vertigo is related to age, course of the disease, ear fullness, and initial hearing levels. Young age, a short course of the disease and ear fullness are positive factors for a good prognosis of low-frequency descending sudden hearing loss without vertigo.

Key words: Low-frequency descending type, Sudden hearing loss, Prognosis

中图分类号: 

  • R764.21
[1] 中华耳鼻咽喉头颈外科杂志编辑委员会, 中华医学会耳鼻咽喉头颈外科学分会. 突发性聋诊断和治疗指南(2015)[J]. 中华耳鼻咽喉头颈外科杂志, 2015,50(6):443-447. Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association Otorhinolaryngology Head and Neck Surgery Branch. Sudden deafness diagnosis and treatment guidelines(2015)[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2015, 50(6):443-447.
[2] Oishi N, Inoue Y, Saito H, et al. Long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome[J]. Otolaryngol Head Neck Surg, 2010, 142(4): 565-569. doi:10.1016/j.otohns. 2009.12.006.
[3] 叶毅良,卢标清.704例突发性耳聋患者疗效分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(5):44-47. doi: 10.6040/j.issn.1673-3770.0. 2019.052. Ye Yiliang, Lu Bbiaoqing. Therapeutic outcome analysis of 704 cases of sudden deafness[J]. Journal of Otolaryngology and Ophthalmology of Shandong University. 2019, 33(5):44-47. doi: 10.6040/j.issn.1673-3770.0. 2019.052.
[4] Lin HC, Chou YC, Wang CH, et al. Correlation between auditory brainstem response and hearing prognosis in idiopathic sudden sensorineural hearing loss patients[J]. Auris Nasus Larynx, 2017, 44(6): 678-684. doi:10.1016/j.anl. 2017.01.004.
[5] 雷艳, 康厚墉, 胡国华, 等. 耳蜗电图SP/AP面积比在梅尼埃病诊断中的应用研究[J]. 重庆医科大学学报, 2016, 41(6): 632-636. doi:10.13406/j.cnki.cyxb. 000981. LEI Yan, KANG Houyong, HU Guohua, et al. Application of SP/AP area ratio of electrocochleography in the diagnosis of Meniere's disease[J]. J Chongqing Med Univ, 2016, 41(6): 632-636. doi:10.13406/j.cnki.cyxb. 000981.
[6] Chandrasekhar SS, Tsai Do BS, Schwartz SR, et al. Clinical practice guideline: sudden hearing loss(update)executive summary[J]. Otolaryngol Head Neck Surg, 2019, 161(2): 195-210. doi:10.1177/0194599819859883.
[7] 中国突发性聋多中心临床研究协作组. 中国突发性聋分型治疗的多中心临床研究[J]. 中华耳鼻咽喉头颈外科杂志, 2013, 48(5): 355-361. doi:10.3760/cma.j.issn.1673-0860. 2013.05.002. Chinese Sudden Hearing Loss Multicenter Clinicali Class. Prospective clinical multi-center study on the treatment of sudden deafness with different typings in China[J]. Chin J Otorhinolaryngol Head Neck Surg, 2013, 48(5): 355-361. doi:10.3760/cma.j.issn.1673-0860. 2013.05.002.
[8] Junicho M, Aso S, Fujisaka M, et al. Prognosis of low-tone sudden deafness - does it inevitably progress to Meniere's disease?[J]. Acta Otolaryngol, 2008, 128(3): 304-308. doi:10.1080/00016480601002096.
[9] Yamasoba T, Kikuchi S, Sugasawa M, et al. Acute low-tone sensorineural hearing loss without vertigo[J]. Arch Otolaryngol Head Neck Surg, 1994, 120(5): 532-535. doi:10.1001/archotol.1994. 01880290042007.
[10] Fuse T, Hayashi T, Oota N, et al. Immunological responses in acute low-tone sensorineural hearing loss and Ménière's disease[J]. Acta Otolaryngol, 2003, 123(1): 26-31. doi:10.1080/0036554021000028074.
[11] Wu R, Hoshino T. Long-term changes in off-lesion endocochlear potential after induction of localized lesions in the lateral wall[J]. Ann Otol Rhinol Laryngol, 2001, 110(3): 271-276. doi:10.1177/000348940111000313.
[12] Shiraishi T, Kubo T, Matsunaga T. Chronological study of recovery of sudden deafness treated with defibrinogenation and steroid therapies[J]. Acta Otolaryngol, 1991, 111(5): 867-871. doi:10.3109/00016489109138423.
[13] 张祥宝, 胡宝华. 巴曲酶联合早期鼓室内注射甲泼尼龙琥珀酸钠治疗突发性聋[J]. 中国耳鼻咽喉头颈外科, 2017, 24(1): 46-48. doi:10.16066/j.1672-7002. 2017.01.012.
[14] 王春花, 王小锐, 康艳霞, 等. 单侧低中频下降型突发性聋预后相关因素分析[J]. 中华耳科学杂志, 2014, 12(4): 603-607. WANG Chunhua, WANG Xiaorui, KANG Yanxia, et al. Factors affecting prognosis in unilateral low-middle frequency sudden hearing loss[J]. Chin J Otol, 2014, 12(4): 603-607. doi: 10.3969/j.issn.1672-2922. 2014.04.024.
[15] Chang NC, Ho KY, Kuo WR. Audiometric patterns and prognosis in sudden sensorineural hearing loss in southern Taiwan[J]. Otolaryngol Head Neck Surg, 2005, 133(6): 916-922. doi:10.1016/j.otohns. 2005.09.018.
[16] 钱怡, 钟时勋, 胡国华, 等. 突发性耳聋的分型治疗及预后分析[J]. 重庆医科大学学报, 2015, 40(8): 1159-1163. doi:10.13406/j.cnki.cyxb.000581. QIAN Yi, ZHONG Shixun, HU Guohua, et al. Treatment and prognosis for sudden deafness[J]. J Chongqing Med Univ, 2015, 40(8): 1159-1163. doi:10.13406/j.cnki.cyxb. 000581.
[17] 王晓丽, 刘伟, 谢淑敏, 等. 突发性聋患者耳闷胀感与疗效的相关分析[J]. 中华耳鼻咽喉头颈外科杂志, 2015, 50(6): 458-462. doi:10.3760/cma.j.issn.1673-0860. 2015.06.005. WANG Xiaoli, LIU Wei, XIE Shumin,et al. Clinical multi-center study on the treatment of sudden sensorineural hearing loss accompanied with feeling of ear fullness[J]. Chin J Otorhinolaryngol Head Neck Surg, 2015, 50(6): 458-462. doi:10.3760/cma.j.issn.1673-0860. 2015.06.005.
[18] 周恩, 刘斌, 赵鹏, 等. 低频型突聋伴耳闷胀感患者耳闷胀感特征及与突聋的关系[J]. 中华耳科学杂志, 2017, 15(2): 201-206. doi: 10.3969/j.issn.1672-2922. 2017.02.012. ZHOU En, LIU Bin, ZHAO Peng, et al. Characteristics of ear fullness in patients with low frequency sudden deafness and their relationship[J]. Chin J Otol, 2017, 15(2): 201-206. doi: 10.3969/j.issn.1672-2922. 2017.02.012.
[19] Sakata T, Esaki Y, Yamano T, et al. A comparison between the feeling of ear fullness and tinnitus in acute sensorineural hearing loss[J]. Int J Audiol, 2008, 47(3): 134-140. doi:10.1080/14992020701760547.
[20] Merwin GE, Boies LR Jr. Paper patch repair of blast rupture of the tympanic membrane[J]. Laryngoscope, 1980, 90(5 Pt 1): 853-860. doi: 10.1288/00005537-198005000-00017.
[21] Rask-Andersen H, Kinnefors A, Illing RB. On a novel type of neuron with proposed mechanoreceptor function in the human round window membrane: an immunohistochemical study[J]. Rev Laryngol Otol Rhinol(Bord), 1999, 120(3): 203-207.
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