E-cadherin和ZEB2在鼻腔鼻窦内翻性乳头状瘤中的表达及其临床意义

doi:10.6040/j.issn.1673-3770.0.2020.127

摘要/Abstract

摘要： 目的探讨E-cadherin mRNA和ZEB2 mRNA在鼻腔鼻窦内翻性乳头状瘤(SNIP)中的表达及其临床意义。方法采用荧光定量PCR法检测E-cadherin mRNA和ZEB2 mRNA在51例SNIP和20例增生鼻甲组织中的表达,探讨E-cadherin mRNA和ZEB2 mRNA表达与SNIP患者临床病理参数之间的关系以及两者之间的相关性。结果 (1) E-cadherin mRNA在SNIP中的表达水平低于增生鼻甲组织(P=0.007),ZEB2 mRNA在SNIP中的表达水平高于增生鼻甲组织(P=0.034),差异均具有统计学意义;(2) E-cadherin mRNA的低表达和ZEB2 mRNA的高表达与SNIP年龄、性别、临床分期及是否复发均无明显相关性,而与SNIP病理分化程度有关,其中在无不典型增生组与恶变组之间的表达差异具有统计学意义;(3) E-cadherin mRNA和ZEB2 mRNA的表达呈负相关(r=-0.317, P=0.023)。结论在SNIP中 E-cadherin mRNA表达下调、ZEB2 mRNA表达上调,两者的异常表达呈负相关,且均与SNIP病理分化程度有关,其中在无不典型增生组与恶变组之间的表达差异均具有统计学意义,ZEB2 mRNA可能通过下调E-cadherin mRNA的表达进而促进SNIP的发生及恶变。

关键词: E-cadherin, ZEB2, 鼻腔鼻窦内翻性乳头状瘤, 病理分化程度, 发生, 恶变

Abstract: Objective To investigate the expressions of E-cadherin and ZEB2 mRNAs in sinonasal inverted papilloma(SNIP)and assess their clinical significance. Methods Quantitative fluorescence polymerase chain reaction was performed to detect the expressions of E-cadherin and ZEB2 mRNAs in 51 cases of SNIP and 20 cases of hyperplastic turbinate tissues and investigate the relationship and correlation between E-cadherin and ZEB2 mRNA expressions and clinicopathological parameters of SNIP patients. Results The expression of E-cadherin mRNA was lower in SNIP than in hyperplastic turbinate tissue(P=0.007)and that of ZEB2 mRNA was higher in SNIP than in hyperplastic turbinate tissue(P=0.034), both with statistically significant differences. The low expression of E-cadherin mRNA and high expression of ZEB2 mRNA were not related to the age, sex, clinical stage, or recurrence of SNIP, but were related to the pathological differentiation of SNIP. Further, the difference between the atypical hyperplasia and malignant transformation groups was statistically significant. The expressions of E-cadherin and ZEB2 mRNAs correlated negatively(r=-0.317, P=0.023). Conclusion In SNIP, the E-cadherin mRNA expression was downregulated, whereas ZEB2 mRNA expression was upregulated, showing a negative correlation. Both abnormal expressions were related to the pathologic differentiation of SNIP. The mechanism may be downregulation of the E-cadherin expression by ZEB2, promoting the occurrence and malignant transformation of SNIP.

Key words: E-cadherin, ZEB2, Sinonasal inverted papilloma, Degree of pathological differentiation, Occurrence, Malignant transformation

中图分类号:

R739.62

石书婧,方静蕾,张安琪,徐莉,刘冉冉,韩振强,王建国. E-cadherin和ZEB2在鼻腔鼻窦内翻性乳头状瘤中的表达及其临床意义[J]. 山东大学耳鼻喉眼学报, 2021, 35(1): 30-34.

SHI Shujing, FANG Jinglei, ZHANG Anqi, XU Li, LIU Ranran, HAN Zhenqiang, WANG Jianguo. Expressions of E-cadherin and ZEB2 in sinonasal inverted papilloma and their clinical significance[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 30-34.

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