山东大学耳鼻喉眼学报 ›› 2022, Vol. 36 ›› Issue (1): 75-80.doi: 10.6040/j.issn.1673-3770.0.2021.028

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皮下免疫治疗对单一尘螨和合并霉菌过敏儿童哮喘的临床研究

李孟辉1,3,郅莉莉2,戚凯文3,4,王珊珊3,高倩1,3,步美玲1,3,姜荷云3,4,冯绛楠3,王金荣3   

  1. 1. 山东中医药大学第二临床医学院, 山东 济南 250004;
    2. 淄博市中心医院 变态反应科, 山东 淄博 255036;
    3. 山东第一医科大学附属省立医院 小儿呼吸科, 山东 济南 250021;
    4. 潍坊医学院, 山东 潍坊 261053
  • 发布日期:2022-02-22
  • 通讯作者: 王金荣. E-mail:jrwang60@163.com
  • 基金资助:
    山东省重点研发计划项目(2015GSF118036)

Clinical research of subcutaneous immunotherapy on children with allergic asthma caused by dust mites and combined with mold allergen

LI Menghui1,3, ZHI Lili2, QI Kaiwen3,4, WANG Shanshan3, GAO Qian1,3, BU Meiling1,3,   

  1. 1. Second Clinical Medical College of Shandong University of Traditional Chinese Medicine, Jinan 250004, Shandong, China;
    2. Zibo Central Hospital Allergy Department of, Zibo 255036, Shandong, China;
    3. Shandong Provincial Hospital of Shandong First Medical University Department of Pediatric Respiratory, Jinan 250021, Shandong, China;
    4. Weifang Medical College, Weifang 261053, Shandong, China
  • Published:2022-02-22

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摘要： 目的 评价特异性皮下免疫治疗(SCIT)对单一尘螨过敏和尘螨合并霉菌过敏的哮喘儿童的疗效。 方法 纳入6~14岁过敏性哮喘儿童,根据过敏原种类,分为单一尘螨组与尘螨合并霉菌组,给予SCIT。治疗12、24个月时,比较组内和组间的哮喘控制问卷(ACQ)评分、药物评分和肺功能指标［第1秒用力呼气的容积占预计值的百分比(FEV1%)、呼出50%肺活量时最大呼气流量占预计值的百分比(FEF50%)、呼出75%肺活量时最大呼气流量占预计值的百分比(FEF75%)和用力呼气中期流量占预计值的百分比(MMEF%)］。 结果 共纳入118例哮喘儿童,其中单一尘螨组57例,尘螨合并霉菌组61例。治疗12个月时,两组的ACQ评分、药物评分、FEF50%、FEF75%和MMEF%均较治疗前有改善(均P<0.05),而FEV1%虽较治疗前有改善,但差异无统计学意义(P>0.05);治疗24个月时,两组的ACQ评分、药物评分、FEV1%、FEF50%、FEF75%和MMEF%均较治疗12个月有改善(均P<0.05)。治疗12个月和24个月,两组间ACQ评分、药物评分、FEV1%、FEF50%、FEF75%和MMEF%的改善程度差异均无统计学意义(均P>0.05)。 结论 SCIT可改善过敏性哮喘儿童的临床症状,减少哮喘药物的使用,不仅对大气道有改善,还能改善小气道。SCIT对单一尘螨过敏和尘螨合并霉菌过敏的哮喘患儿疗效相当。

关键词: 特异性免疫治疗, 儿童哮喘, 尘螨, 霉菌

Abstract: Objective To evaluate the efficacy of subcutaneous immunotherapy(SCIT)on children with allergic asthma caused by single dust mite and dust mite with mold respectively. Methods Children aged 6-14 years with allergic asthma were divided into single dust mite allergy group or dust mite with mold allergy group according to allergen species and given SCIT. ACQ score, drug score, lung function indicators(FEV1%, FEF50%, FEF75% and MMEF%)were compared after 12,24 months of treatment within and between groups, respectively. Results A total of 118 asthmatic children were included: 57 in the dust mite group and 61 in the dust mite with mold group. After 12 months of treatment, ACQ score, drug score, FEF50%, FEF75% and MMEF% were significantly improved compared with that before treatment in both groups(all P<0.05). While the FEV1% in both groups were improved compared with that before treatment, but there was no statistical significance(P>0.05). After 24 months of treatment, both groups of ACQ score, drug score, FEV1%,FEF50%,FEF75% and MMEF% have improved significantly of that after 12 months of treatment(all P<0.05). At 12 and 24 months of treatment, there were no significant differences of degree of improvement in ACQ score, drug score, FEV1%, FEF50%, FEF75% and MMEF%(all P>0.05)between two groups. Conclusion The SCIT can significantly improve the clinical symptoms, reduce the use of symptomatic drugs, improve lung function in children with allergic asthma. SCIT not only has a significant effect on single dust mite, but also on dust mite with mold allergen.

Key words: Specific immunotherapy, Children, Asthma, Mold allergen

中图分类号: 

  • R562.2
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