睑板腺功能障碍实验模型及应用现状

doi:10.6040/j.issn.1673-3770.0.2023.077

摘要/Abstract

摘要： 睑板腺功能障碍(meibomian gland dysfunction, MGD)是临床常见的眼表疾病,严重影响患者的日常生活质量。目前 MGD发病机制与治疗手段的相关研究已逐渐成为干眼的研究热点,为此建立一个稳定有效的实验模型对于MGD的深入探索是必要的前提。MGD实验模型目前主要分为在体模型和离体模型两大类:在体模型主要通过药物诱导、手术诱导、基因敲除以及转基因方式建模;离体模型是指在体外模拟睑板腺的病理生理。本文就目前报道的多种MGD实验模型及对其应用评价进行简要综述。

关键词: 睑板腺功能障碍, 干眼, 睑板腺上皮细胞, 睑板腺外植体, 动物模型

Abstract: Meibomian gland dysfunction(MGD)is a common ocular surface disease in clinics that seriously affects the quality of patients' daily life. To date, related research on the pathogenesis and treatment of MGD has gradually become a research hotspot in dry eye. Therefore, the establishment of a stable and effective experimental model is a prerequisite for further exploration of MGD. The experimental models of MGD are divided into two categories: in vivo and in vitro models. The in vivo model is modeled mainly by drug induction, surgical induction, gene knockout, and transgenic methods. The in vitro model is used to simulate the pathophysiology of meibomian glands in vitro. This paper briefly reviews several MGD experimental models reported so far and their evaluation.

Key words: Meibomian gland dysfunction, Dry eye, iHMGEC, Meibomian gland explant, Animal models

中图分类号:

R777.1

毕赵静,李元彬. 睑板腺功能障碍实验模型及应用现状[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 159-165.

BI Zhaojing, LI Yuanbin. Current status of experimental models and applications of meibomian gland dysfunction[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 159-165.

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