山东大学耳鼻喉眼学报 ›› 2025, Vol. 39 ›› Issue (4): 114-127.doi: 10.6040/j.issn.1673-3770.0.2024.354

• 论著 • 上一篇    下一篇

特定部位针刺法治疗突发性聋的疗效及安全性评价:一项系统综述和网状Meta分析

郑泽皓1,魏佳俐1,刘嘉涛1,周玉麒1,孙文婷2,李雨轩2,白鹏2   

  1. 1.北京中医药大学第三附属医院 针灸科, 北京 100029;
    2.北京中医药大学东直门医院 针灸科, 北京 100700
  • 出版日期:2025-07-20 发布日期:2025-08-11
  • 通讯作者: 白鹏. E-mail:baipeng1978@163.com
  • 基金资助:
    北京市自然科学基金(7222283);青年岐黄学者支持项目［国中医药人教函(2022)256号］

Evaluation of the efficacy and safety of site-specific acupuncture for the treatment of sudden hearing loss: a systematic review and network Meta-analysis

ZHENG Zehao1, WEI Jiali1, LIU Jiatao1, ZHOU Yuqi1, SUN Wenting2, LI Yuxuan2, BAI Peng2   

  1. 1. Department of Acupuncture, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China2. Department of Acupuncture, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
  • Online:2025-07-20 Published:2025-08-11

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摘要： 目的 系统评价并比较特定部位针刺法在治疗突发性聋中的疗效及安全性。 方法 检索PubMed、the Cochrane Library、Web of Science、SinoMed、CNKI、万方和维普数据库中关于针刺治疗突发性聋疗效及安全性的随机对照试验。由2位研究者独立使用NoteExpress软件筛选文献并核对后确定纳入文献,使用Excel提取数据,采用the Cochrane Collaboration's RoB 2.0 tool(RoB 2.0)工具评估偏倚风险,并使用R软件进行网状Meta分析。 结果 共纳入20篇文献,涉及1453名患者,评估了13种干预措施。RoB2评估结果显示1项研究的偏倚风险较低,其余研究为中等偏倚风险。网状Meta分析结果表明,针刺对突发性聋疗效显著,尤其是颈项针结合耳针治疗效果最佳。此外针刺与西药联合使用的效果更为显著。在主要结局(治疗后听力提升超过15 dB的患者数)的the surface under the cumulative ranking curve(SUCRA)值排名中,颈项针+耳针+西药(92.3)居首,其次为头面针(80.84)、颈项针+西药(70.64)等。次要结局纯音听阈的排名中,头面针(88.42)排名最高,其次是头面部针灸+耳针+西药(74.15)。安全性方面,5篇文献报告了相关结局,1篇文献报告2组各出现1例皮下血肿与淤青,但未影响试验进行。 结论 特定部位针刺法在治疗突发性聋中效果显著,尤其是颈项针结合耳针的治疗效果突出,且安全性良好。由于纳入研究数量有限,仍需进一步开展高质量的随机对照试验进行验证。

关键词: 特定部位针刺, 突发性耳聋, 系统评价, 疗效排序, 网状Meta分析

Abstract: Objective To systematically evaluate and compare the efficacy and safety of site-specific acupuncture in the treatment of sudden hearing loss. Methods Randomized controlled trials on the efficacy and safety of acupuncture for sudden hearing loss were retrieved from PubMed, the Cochrane Library, Web of Science, SinoMed, CNKi, Wanfang, and VIP databases. Literature was screened and checked independently by two investigators using NoteExpress software to determine the inclusion of literature, data were extracted using Excel, risk of bias was assessed using the Cochrane Collaboration's Risk of Bias(RoB)2.0 tool, and Meta-analysis was performed using R software. Results A total of 20 studies involving 1,453 patients were included, evaluating 13 different interventions. The RoB 2.0 assessment revealed that one study had a low risk of bias, while the remaining studies exhibited a moderate risk of bias. The results of the Meta-analysis indicated that acupuncture was effective in sudden hearing loss, with cervical acupuncture combined with auricular acupuncture showing the greatest efficacy. Additionally, the combination of acupuncture and western medicine demonstrated superior effectiveness. In the ranking of the surface under the cumulative ranking curve(SUCRA)value for the primary outcome(the number of patients with hearing enhancement of more than 15 dB after treatment), cervical acupuncture + auricular acupuncture + western medicine(92.3)ranked highest, followed by cephalic and facial acupuncture(80.84), cervical acupuncture + western medicine(70.64), and so on. The ranking of the secondary outcome pure tone hearing threshold was highest for cephalic and facial acupuncture(88.42), followed by cephalic and facial acupuncture + auricular acupuncture + western medicine(74.15). Regarding safety, five studies reported relevant outcomes, with one study observing a case of subcutaneous hematoma and bruising in both groups, though this did not impact the progress of the trial. Conclusion Site-specific acupuncture is effective in treating sudden hearing loss, especially cervical acupuncture combined with auricular acupuncture, and shows a favorable safety profile. However given the limited number of included studies, further high-quality randomized controlled trials are needed to validate these findings.

Key words: Acupuncture Location Specificity, Sudden Hearing Loss, Systematic Review, Efficacy Ranking, Network Meta-Analysis

中图分类号: 

  • R245
[1] Xie W, Dai Q, Liu J, et al. Analysis of clinical and laboratory findings of idiopathic sudden sensorineural hearing loss[J]. Sci Rep, 2020, 10(1): 6057. doi: 10.1038/s41598-020-63046-z
[2] 中华耳鼻咽喉头颈外科杂志编辑委员会, 中华医学会耳鼻咽喉头颈外科学分会. 突发性聋诊断和治疗指南(2015)[J]. 中华耳鼻咽喉头颈外科杂志, 2015, 50(6): 443-447. doi:10.3760/cma.j.issn.1673-0860.2015.06.002
[3] 中国突发性聋多中心临床研究协作组. 中国突发性聋分型治疗的多中心临床研究[J]. 中华耳鼻咽喉头颈外科杂志, 2013, 48(5): 355-361. doi:10.3760/cma.j.issn.1673-0860.2013.05.002 Chinese sudden hearing loss multi-center clinical study group. Prospective clinical multi-center study on the treatment of sudden deafness with different typings in China[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2013, 48(5): 355-361. doi:10.3760/cma.j.issn.1673-0860.2013.05.002
[4] Chandrasekhar SS, Tsai Do BS, Schwartz SR, et al. Clinical practice guideline: sudden hearing loss(update)[J]. Otolaryngol Head Neck Surg, 2019, 161(1): 1-45. doi: 10.1177/0194599819859885
[5] Wilson BS, Tucci DL, Merson MH, et al. Global hearing health care: new findings and perspectives[J]. Lancet, 2017, 390(10111): 2503-2515. doi: 10.1016/S0140-6736(17)31073-5
[6] 王津华. 中医针灸治疗神经性耳鸣耳聋研究进展[J]. 现代诊断与治疗, 2023, 34(6): 843-845. WANG Jinhua. Research progress of Chinese acupuncture in the treatment of neurological tinnitusand deafness[J]. Modern Diagnosis and Treatment, 2023, 34(6): 843-845.
[7] 张超, 耿培亮, 郭毅, 等. 应用R语言netMeta程序包实现网状Meta分析[J]. 中国循证医学杂志, 2014, 14(5): 625-630. doi:10.7507/1672-2531.20140103 ZHANG Chao, GENG Peiliang, GUO Yi, et al. Application of R language netMeta package for net Meta analysis[J]. Chinese Journal of Evidence-Based Medicine, 2014,14(5): 625-630. doi:10.7507/1672-2531.20140103
[8] 郑中立. 耳鼻咽喉科诊断学[M]. 2版. 北京: 人民卫生出版社, 2006
[9] 国家中医药管理局.中医病证诊断疗效标准[M]. 南京: 南京大学出版社, 1994
[10] 高树中. 针灸治疗学/全国中医药行业高等教育“十三五”规划教材[M]. 北京: 中国中医药出版社, 2016
[11] Sterne JAC, Savovic J, Page MJ, etal. RoB 2: a revised tool for assessing risk of bias in randomised trials[J]. BMJ, 2019, 366: l4898. doi:10.1136/bmj.l4898
[12] 刘括, 孙殿钦, 廖星, 等. 随机对照试验偏倚风险评估工具2.0修订版解读[J]. 中国循证心血管医学杂志, 2019, 11(3): 284-291. doi:10.3969/j.issn.1674-4055.2019.03.05 LIU Kuo, SUN Dianqin, LIAO Xing, et al. Bias risk review tool(2.0 revision)for randomized controlled trials[J]. Chinese Journal of Evidence-Based Cardiovascular Medicine, 2019, 11(3): 284-291. doi:10.3969/j.issn.1674-4055.2019.03.05
[13] 刘津池, 刘畅, 华成舸. 随机对照试验偏倚风险评价工具RoB2(2019修订版)解读[J]. 中国循证医学杂志, 2021, 21(6): 737-744. doi:10.7507/1672-2531.202011144 LIU Jinchi, LIU Chang, HUA Chengge. Risk bias assessment tool RoB2(revised version 2019)for randomized controlled trial: an interpretation[J]. Chinese Journal of Evidence-Based Medicine, 2021, 21(6): 737-744. doi:10.7507/1672-2531.202011144
[14] 向虹, 岳磊, 赵红, 等. 应用R语言BUGSnet程序包实现贝叶斯网状Meta分析[J]. 中国循证医学杂志, 2022, 22(5):600-608. doi:10.7507/1672-2531.202111140 XIANG Hong, YUE Lei, ZHAO Hong, et al. Implementation of bayesian network meta-analysis with BUGSnet package in r software[J]. Chinese Journal of Evidence-based Medicine, 2022, 22(5): 600-608. doi: 10.7507/1672-2531.202111140
[15] Eckermann S, Coory M, Willan AR. Indirect comparison: relative risk, fall-cies, and odds solution[J]. J Clin Epidemiol, 2009, 62(10): 1031-1036. doi: 10.1016/j.jclinepi.2008.10.013
[16] 田金徽, 李伦. 网状Meta分析方法与实践[M]. 北京: 中国医药科技出版社, 2017.
[17] Higgins J, Thomas J. Cochrane handbook for systematic reviews of interventions version 6.2[M/OL]. Chichester(UK): John Wiley & Sons, 2019. https://training.cochrane.org/handbook/archive/v6.2.
[18] Watt J, Del Giovane C. Network Meta-Analysis[J]. Methods Mol Biol, 2022, 2345: 187-201. doi: 10.1007/978-1-0716-1566-9_12
[19] Chaimani A, Salanti G. Visualizing assumptions and results in network Meta-analysis: the network graph package[J]. Stata Journal, 2015, 15: 905-950. doi:10.1177/1536867x1501500402
[20] 李淑敏. 颈部七线疗法治疗肝火上炎型突发性聋的临床研究[J]. 北京: 北京中医药大学, 2018
[21] 李种泰. 针刺颈段夹脊穴治疗突发性耳聋31例临床观察[J]. 中国民族民间医药, 2014, 23(21): 47-48 LI Zhongtai. Clinical observation of 31 cases of sudden hearing loss treated with acupuncture at cervical Jiaji points[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2014, 23(21): 47-48
[22] 梁美莹. 脐针治疗气滞血瘀型感音神经性耳聋的临床研究[D]. 南宁: 广西中医药大学, 2022
[23] 梁云, 雷刚, 王林林, 等. 腹针“引气归元” 针法联合鼓室注射治疗暴聋(气血亏虚证)临床研究[J]. 中国中医急症, 2021, 30(3): 454-457. doi:10.3969/j.issn.1004-745X.2021.03.021 LIANG Yun, LEI Gang, WANG Linlin, et al. Clinical study on abdominal acupuncture combined with intratympanic steroid therapy for sudden deafness with qi and blood deficiency syndrome[J]. Journal of Emergency in Traditional Chinese Medicine, 2021, 30(3): 454-457. doi:10.3969/j.issn.1004-745X.2021.03.021
[24] 刘梦晨, 朱玲, 吴飞虎. 耳五针治疗气滞血瘀型突发性耳聋疗效观察[J]. 中医药临床杂志, 2018, 30(6): 1083-1085. doi:10.16448/j.cjtcm.2018.0329 LIU Mengchen, ZHU Ling, WU Feihu. Clinical observation of ear five acupuncture in the treatment of qi stagnation and blood stasis type sudden deafness[J]. Clinical Journal of Traditional Chinese Medicine, 2018, 30(6): 1083-1085. doi:10.16448/j.cjtcm.2018.0329
[25] 刘天奇. 针刺颈夹脊穴为主治疗突发性耳聋的临床观察[D]. 长春: 长春中医药大学, 2017
[26] 刘振, 秦黎虹. 颈项针结合耳周腧穴治疗突发性耳聋[J]. 中医药临床杂志, 2015, 27(4): 531-533. doi:10.16448/j.cjtcm.2015.0202 LIU Zhen, QIN Lihong. Nape acupuncture combined with the points around ear in the treatment of sudden deafness[J]. Clinical Journal of Traditional Chinese Medicine, 2015, 27(4): 531-533. doi:10.16448/j.cjtcm.2015.0202
[27] 栾先丹. 眼针联合体针治疗感音神经性耳聋临床观察[J]. 中国中医药现代远程教育, 2023, 21(5): 121-123. doi:10.3969/j.issn.1672-2779.2023.05.045 LUAN Xiandan. Clinical observation on eye acupuncture combined with body acupuncture in the treatment of sensorineural deafness[J]. Chinese Medicine Modern Distance Education of China, 2023, 21(5): 121-123. doi:10.3969/j.issn.1672-2779.2023.05.045
[28] 聂艳. 头皮针配合耳三针治疗突发性聋的临床疗效观察[D]. 晋中: 山西中医药大学, 2020
[29] 韩丽, 谯凤英. 小醒脑针法辅助治疗突聋后期的临床疗效观察[J]. 辽宁中医杂志, 2009, 36(4): 622-623. doi: 10.13192/j.ljtcm.2009.04.129.hanl.052
[30] 谭方艺. 项针治疗突发性感音神经性聋患者的临床疗效观察[D]. 黑龙江中医药大学, 2023. doi: 10.27127/d.cnki.ghlzu.2023.000152
[31] 陶然, 左歆, 柏杉, 等. 经颅重复针刺法结合电针治疗平坦下降型突发性耳聋: 随机对照试验[J]. 中国针灸, 2023, 43(8): 932-936. doi:10.13703/j.0255-2930.20230223-k0002 TAO Ran, ZUO Xin, BAI Shan, et al. Repeated transcranial acupuncture combined with electroacupuncture for flat descending sudden deafness: a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2023, 43(8): 932-936. doi:10.13703/j.0255-2930.20230223-k0002
[32] 王新茹. “颈部七线法”改善难治性突发性聋患者耳鸣症状的临床研究[D]. 北京: 北京中医药大学, 2022
[33] 王歆婷, 郑士立, 方芳, 等. 针刺项三穴治疗突发性聋的临床疗效及对血液流变学的影响[J]. 浙江中医杂志, 2021, 56(3): 213-214. doi:10.3969/j.issn.0411-8421.2021.03.041 WANG Xinting, ZHENG Shili, FANG Fang, et al. Zhejiang Journal of Traditional Chinese Medicine, 2021, 56(3): 213-214. doi:10.3969/j.issn.0411-8421.2021.03.041
[34] 王玥, 高维滨. 电项针治疗突发性聋的疗效观察[J]. 针灸临床杂志, 2006, 22(4): 33-34. doi:10.3969/j.issn.1005-0779.2006.04.023 WANG Yue, GAO Weibin. Observation of effectiveness with sudden deafness treated with electro-nape-acupuncture[J]. Journal of Clinical Acupuncture and Moxibustion, 2006, 22(4): 33-34. doi:10.3969/j.issn.1005-0779.2006.04.023
[35] 于晓东. 项夹脊电针结合局部腧穴治疗突发性耳聋的临床观察[D]. 哈尔滨: 黑龙江中医药大学, 2013
[36] 苑文佳. 颈部七线法治疗感音神经性耳聋的临床疗效观察[D]. 北京: 北京中医药大学, 2019
[37] 张萍萍, 高维滨, 鞠丹. 电项针为主治疗特发性突聋的临床观察[J]. 针灸临床杂志, 2012, 28(2): 44-45. doi:10.3969/j.issn.1005-0779.2012.02.020 ZHANG Pingping, GAO Weibin, JU Dan. Journal of Clinical Acupuncture and Moxibustion, 2012, 28(2): 44-45. doi:10.3969/j.issn.1005-0779.2012.02.020
[38] 赵俐黎. 小醒脑针法辨治突发性耳聋110例[J]. 中医研究, 2006, 19(12): 48-49. doi:10.3969/j.issn.1001-6910.2006.12.026 ZHAO Lili. Therapy of 110 cases of sudden deafness by acupuncture[J]. Traditional Chinese Medicinal Research, 2006, 19(12): 48-49. doi:10.3969/j.issn.1001-6910.2006.12.026
[39] 郑振, 石晶. 眼针治疗突发性耳聋42例疗效观察[J]. 中国针灸, 2002, 22(8): 523-524 ZHENG Zhen, SHI Jing. Observation on the therapeutic effect of eye acupuncture for 42 cases of sudden deafness[J]. Chinese Acupuncture & Moxibustion, 2002, 22(8): 523-524
[40] 石安妮, 张佳佳, 白鹏, 等. 浅析 “颈部七线法” 针刺治疗突发性耳聋的内涵[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 103-107, 128. doi:10.6040/j.issn.1673-3770.0.2021.412 SHI Anni, ZHANG Jiajia, BAI Peng, et al. Analysis of a therapeutic modality for sudden deafness utilizing neck acupuncture comprising seven lines of treatment[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 103-107, 128. doi:10.6040/j.issn.1673-3770.0.2021.412
[41] Sina RE, Lippert J, Guardardo K. Osteopathic cranial manipulative medicine as a proposed addition to the treatment Regimen for Idiopathic Sudden-Onset Unilateral Sensorineural Hearing Loss: A Case Report[J]. Cureus. 2023, 15(11):49728. doi:10.7759/cureus.49728
[42] 谢芳, 张国勇, 张博达. 基于数据挖掘分析针刺治疗突发性耳聋的选穴规律[J]. 湖南中医杂志, 2023, 39(8): 42-46. doi:10.16808/j.cnki.issn1003-7705.2023.08.009 XIE Fang, ZHANG Guoyong, ZHANG Boda. Acupoint selection in acupuncture for the treatment of sudden deafness: a study based on data mining techniques[J]. Hunan Journal of Traditional Chinese Medicine, 2023, 39(8): 42-46. doi:10.16808/j.cnki.issn1003-7705.2023.08.009
[43] 黄雄超, 覃冠锻, 陈冉, 等. “耳一针” 针刺联合聪耳息鸣汤加减治疗难治性突发性聋的临床效果[J]. 广西医学, 2023, 45(5): 550-552, 566. doi:10.11675/j.issn.0253-4304.2023.05.11 HUANG Xiongchao, QIN Guanduan, CHEN Ran, et al. Clinical effect of “Eryizhen” acupuncture combined with modified Conger Ximing Decoction in the treatment of refractory sudden deafness[J]. Guangxi Medical Journal, 2023, 45(5): 550-552, 566. doi:10.11675/j.issn.0253-4304.2023.05.11
[44] 祁晓晗, 王新茹, 马莉, 等. 颈部七线法治疗突发性聋思路探析[J]. 北京中医药, 2022, 41(4): 399-402. doi:10.16025/j.1674-1307.2022.04.013 QI Xiaohan, WANG Xinru, MA Li, et al. Analysis of neck seven-line method in the treatment of sudden deafness[J]. Beijing Journal of Traditional Chinese Medicine, 2022, 41(4): 399-402. doi:10.16025/j.1674-1307.2022.04.013
[45] Alnafie MA. Bilateral duplicated hypoplastic superior cerebellar arteries one of which originates from a full-type fetal posterior cerebral artery[J]. Surg Radiol Anat. 2023, 45(10):1295-1300. doi:10.1007/s00276-023-03230-8
[46] Piccinin MA, Munakomi S. Neuroanatomy, Vertebrobasilar system[M]. In: StatPearls. Treasure Island(FL): StatPearls Publishing, 2023
[47] Mei Y, Guan D, Tong X, et al. Association of cerebral infarction with vertebral arterial fenestration using non-Newtonian hemodynamic evaluation[J]. Math Biosci Eng, 2022, 19(7): 7076-7090. doi: 10.3934/mbe.2022334
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