关键词: 表达, 单核细胞趋化蛋白1, 耳部瘢痕疙瘩, 骨形成蛋白7

Abstract:

Objective    To explore the roles of MCP-1 and BMP-7 in the formation of auricular keloids. Methods    Immunohistochemistry method was used to detect MCP-1 and BMP-7 expression in 29 cases of auricular keloid tissues and 22 cases of normal skin tissue. The correlation between MCP-1 and BMP-7 expression in auricular keloid tissues was discussed. Results    The positive rate of MCP-1in auricular keloids group was 82.76%, which was significantly higher than that of non-pathological scar group (28.57%) and the control group(9.09%) (χ2=12.033, 24.350;  all P＜0.05); The positive rate of BMP-7 in keloids group was 17.24%, which was significantly lower than that of non-pathological scar group (57.14%) and the control group(81.82%) (χ2=9.442, 18.432; all P＜0.05). A negative correlation between MCP-1 and BMP-7 expression of auricular keloid tissues was noted(r=-0.538，P＜0.05). Conclusion    MCP-1 and BMP-7 participate in the regulation of auricular keloid formation process.  BMP-7 can be used as an ideal target in gene therapy to prevent keloids.

Key words: MCP-1, Auricular keloid, Expression, BMP-7