山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (5): 76-78.doi: 10.6040/j.issn.1673-3770.0.2015.184

• 综述 • 上一篇    下一篇

慢性鼻-鼻窦炎小鼠模型及应用现状

王志远, 张革化   

  1. 中山大学附属第三医院耳鼻咽喉-头颈外科, 广东 广州 510630
  • 收稿日期:2015-05-10 修回日期:2015-09-21 出版日期:2015-10-16 发布日期:2015-10-16
  • 通讯作者: 张革化,E-mail:gehuazh@hotmail.com E-mail:gehuazh@hotmail.com
  • 作者简介:王志远,E-mail:wzyrobert@hotmail.com
  • 基金资助:
    国家自然科学基金(81371073);广州市天河区科技计划项目(201409KW027)

Establishment and application of model of chronic rhinosinusitis in mice

WANG Zhiyuan, ZHANG Gehua   

  1. Department of Otolaryngology & Head and Neck Surgery, Guangzhou 510630, Guangdong, China
  • Received:2015-05-10 Revised:2015-09-21 Online:2015-10-16 Published:2015-10-16

摘要: 慢性鼻-鼻窦炎(CRS)是上呼吸道常见的慢性炎症性疾病,严重影响了患者生活质量,目前其发病机制尚不明确。CRS的动物模型是研究人类CRS病理机制和疗效的理想手段。小鼠是目前CRS常用的造模动物。就小鼠CRS的造模方法、模型评价指标及模型的应用现状等做研究综述。

关键词: 鼻息肉, 文献综述, 慢性鼻-鼻窦炎, 小鼠, 动物模型

Abstract: Chronic rhinosinusitis(CRS) is a common chronic inflammatory disease of the upper respiratory tract, which seriously affects the patients' quality of life. Because of its uncertain pathogenesis, the curative effect is not satisfactory. Animal model of CRS is the ideal means for study of the human CRS pathological mechanism and curative effect. Mice are currently common CRS animals. The main content of the review includes research progress of the mice CRS-building methods, the evaluation index and application status of the model.

Key words: Nasal polyps, Animal model, Mouse, Literature review, Chronic rhinosinusitis

中图分类号: 

  • R765.4
[1] Blackwell D L, Collins J G, Coles R. Summary health statistics for U.S. adults: National Health Interview Survey, 1997[J]. Vital Health Stat, 2002(205):1-109.
[2] Bachert C, Zhang N, van Z T, et al. Chronic rhinosinusitis: From one disease to different phenotypes[J]. Pediatr Allergy Immunol, 2012, 23 Suppl 22:2-4.
[3] Shi J B, Fu Q L, Zhang H, et al. Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities[J]. Allergy, 2015, 70(5):533-539.
[4] Xie D Y, Ju J B, Yu H L, et al. Rabbit is suitable for establishing an animal model of rhino-sinusitis[J]. Zhongguo Zuzhi Gongcheng Yanjiu, 2014, 18(18):2830-2835.
[5] Casteleyn C, Cornillie P, Hermens A, et al. Topography of the rabbit paranasal sinuses as a prerequisite to model human sinusitis[J]. Rhinology, 2010, 48(3):300-304.
[6] Wang H, Long X B, Cao P P, et al. Clara cell 10-kD protein suppresses chitinase 3-like 1 expression associated witheosinophilic chronic rhinosinusitis[J]. Am J Respir Crit Care Med, 2010, 181(9):908-916.
[7] Ahn B H, Park Y H, Song D W. A mouse model of acute and chronic rhinosinusitis[J]. Otolaryngol Head Neck Surg, 2005, 133(3):258-259.
[8] 王恒,刘争,陆翔, 等.Clara细胞10-KDa蛋白在小鼠细菌性慢性鼻-鼻窦炎模型中的表达[J]. 临床耳鼻咽喉头颈外科杂志, 2008, 22(20):937-940. WANG Heng, LIU Zheng, LU Xiang, et al. Expression of Clara cell 10-KDa protein in murine bacterial chronic rhinosinusitis model[J]. J Clin Otorhinolaryngol Head Neck Surgery, 2008, 22(20):937-940.
[9] Jacob A, Faddis B T, Chole R A. Chronic bacterial rhinosinusitis: description of a mouse model[J]. Arch Otolaryngol Head Neck Surg, 2001,127(6):657-664.
[10] 俞晨杰,陆玲,顾亚军, 等. 大鼠慢性鼻-鼻窦炎模型的建立及其生物学特性观察[J]. 中国耳鼻咽喉颅底外科杂志,2011,17(6):419-424. YU Chenjie, LU Ling, GU Yajun, et al. Development of a rat model of chronic rhinosinusitis and observation of biological characteristics[J]. Chin J Otorhinolaryngol Skull Base Surgery, 2011, 17(6):419-424.
[11] Wang E T, Zheng Y, Liu P F, et al. Eosinophilic chronic rhinosinusitis in East Asians[J]. World J Clin Cases, 2014, 2:873-882.
[12] Fokkens W, Lund V, Mullol J, et al. European position paper on rhino-sinusitis and nasal polyps 2012[J]. Rhinol Suppl, 2012, 23:1-298.
[13] Newman L J, Platts-Mills T A, Phillips C D, et al. Chronic sinusitis: relationship of computed tomographic findings to allergy, asthma, and eosinophilia[J]. JAMA, 1994, 271(5):363-367.
[14] Szucs E, Ravandi S, Goossens A, et al. Eosinophilia in the ethmoid mucosa and its relationship to the severity of inflammation in chronic rhinosinusitis[J]. Am J Rhinol, 2002, 16(3):131-134.
[15] Lindsay R, Slaughter T, Britton-Webb J, et al. Development of a murine model of chronic rhinosinusitis[J]. Otolaryngol Head Neck Surg, 2006, 134(5):724-730.
[16] Ahn B H, Park Y H, Shin S H. Mouse model of Aspergillus and Alternaria induced rhinosinusitis[J]. Auris Nasus Larynx, 2009, 36(4):422-426.
[17] Kim S W, Kim D W, Khalmuratova R, et al. Resveratrol prevents development of eosinophilic rhinosinusitis with nasal polypsin a mouse model[J]. Allergy, 2013, 68(7):862-869.
[18] Khalid A N, Hunt J, Perloff J R, et al. The role of bone in chronic rhinosinusitis[J]. Laryngoscope, 2002, 112(11):1951-1957.
[19] Sautter N B, Delaney K L, Hausman F A, et al. Tissue remodeling gene expression in a murine model of chronic rhinosinusitis[J]. Laryngoscope, 2012, 122(4):711-717.
[20] Lane A P, Turner J, May L, et al. A genetic model of chronic rhinosinusitis-associated olfactory inflammationreveals reversible functional impairment and dramatic neuroepithelial reorganization[J]. J Neurosci, 2010, 30(6):2324-2329.
[21] Turner J H, Liang K L, May L, et al. Tumor necrosis factor alpha inhibits olfactory regeneration in a transgenic modelof chronic rhinosinusitis-associated olfactory loss[J]. Am J Rhinol Allergy, 2010, 24(3):336-340.
[22] Ostrowski L E, Yin W, Rogers T D, et al. Conditional deletion of dnaic1 in a murine model of primary ciliary dyskinesiacauses chronic rhinosinusitis[J]. Am J Respir Cell Mol Biol, 2010, 43(1):55-63.
[23] Lee K I, Kim D W, Kim E H, et al. Cigarette smoke promotes eosinophilic inflammation, airway remodeling, and nasal polyps in a murine polyp model[J]. Am J Rhinol Allergy, 2014, 28(3):208-214.
[1] 宋晓宇, 张宇, 李成林, 宋西成. 加速康复外科理念在慢性鼻-鼻窦炎伴鼻息肉手术治疗中的应用[J]. 山东大学耳鼻喉眼学报, 2018, 32(5): 9-12.
[2] 黄远,巴罗,李波,余文兴,杨芳丽,杜进涛. 慢性鼻窦炎鼻息肉中转录因子NKX2-1调控嗜酸性炎症反应的作用[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 17-23.
[3] 陈望兴,赵雪,刘岩,刘悦,金春顺. 鼻中隔偏曲及慢性鼻窦炎鼻息肉患者的精神心理状态调查[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 24-27.
[4] 黄凯丰. 糖皮质激素短疗程雾化吸入对嗜酸粒细胞性鼻窦炎伴鼻息肉患者鼻部症状及肾上腺皮质功能的影响[J]. 山东大学耳鼻喉眼学报, 2018, 32(4): 28-31.
[5] 李华斌, 赖玉婷. 慢性鼻-鼻窦炎的发病机制及诊疗进展[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 4-9.
[6] 于倩倩,关鸽,张念凯,李娜,温君凤,刘婷婷,连媛媛. 鼻腔嗅裂区呼吸道上皮腺瘤样错构瘤的CT影像表现[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 76-81.
[7] 李宏梅,王兰,高照慧,王莹,薛金梅. p-ERK2及ERK2在鼻息肉组织的表达及其意义[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 42-46.
[8] 张劼,龚齐. 不同分型慢性鼻-鼻窦炎患者外周血嗜酸性粒细胞与中性粒细胞百分比及变态反应临床差异性分析[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 54-57.
[9] 甘彬,张永举,许安廷. BRF2在慢性鼻-鼻窦炎伴鼻息肉发病过程中的作用研究[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 47-53.
[10] 龚齐,张劼,赵屏屏. 鼻腔扩容术对慢性鼻-鼻窦炎伴睡眠呼吸暂停[J]. 山东大学耳鼻喉眼学报, 2018, 32(2): 52-55.
[11] 林兴,林宗通,沈翎. 鼻窦球囊扩张治疗儿童慢性鼻窦炎的系统评价及Meta分析[J]. 山东大学耳鼻喉眼学报, 2017, 31(6): 79-86.
[12] 郅莉莉,宋道亮. 嗜酸性粒细胞及IL5在上颌窦后鼻孔息肉与鼻息肉中表达的差异[J]. 山东大学耳鼻喉眼学报, 2017, 31(4): 43-46.
[13] 胡锦东,刘新泉. 干眼动物模型研究进展[J]. 山东大学耳鼻喉眼学报, 2017, 31(4): 109-113.
[14] 李莉珠,吴卿,易欣,田理. 变应性鼻炎中医证候动物模型的研究进展[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 60-63.
[15] 伦杰,张亚楠. 慢性鼻-鼻窦炎伴鼻息肉复发的相关影响因素分析[J]. 山东大学耳鼻喉眼学报, 2017, 31(3): 80-83.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!