山东大学耳鼻喉眼学报 ›› 2017, Vol. 31 ›› Issue (5): 85-88.doi: 10.6040/j.issn.1673-3770.0.2017.187

• 论著 • 上一篇    下一篇

全身麻醉对单纯鼾症患者术后认知功能的影响

耿聪1,张丽伟1,丁明2   

  1. 1. 潍坊医学院麻醉学系, 山东 潍坊 261053;
    2. 解放军89医院麻醉科, 山东 潍坊 261000
  • 收稿日期:2017-05-02 出版日期:2017-10-16 发布日期:2017-10-16
  • 通讯作者: 丁明. E-mail:DM6689@163.com
  • 基金资助:
    原济南军区后勤部面上课题(基金号:CJN15J045)

The effect of general anesthesia on postoperative cognitive function in patients with simple snoring.

GENG Cong1, ZHANG Liwei1, DING Ming2   

  1. 1. Anaesthesiology, Weifang Medical College, Weifang 261053, Shandong, China;2. Department of Anesthesiology, No.89 Hospital of Peoples Liberation Army, Weifang 261000, Shandong, China
  • Received:2017-05-02 Online:2017-10-16 Published:2017-10-16

摘要: 目的 通过评估单纯鼾症患者全身麻醉(全麻)手术前后血清S100β蛋白、血清神经元特异性烯醇化酶(NSE)的相关性,探讨全麻对该类患者手术前后认知功能的影响。 方法 择期全麻关节镜检查术,单纯鼾症(AHI<5)及睡眠正常患者各30例,术前、术后通过蒙特利尔认知功能量表(Montreal cognitive assessment, Mo CA)评估认知功能,分析两组血清S100β、NSE的变化趋势。 结果 与术前比,两组血清S100β及NSE在术毕及术后6 h、12 h升高(P<0.05)。与正常组比,鼾症组Mo CA评分差异无统计学意义(P>0.05),但血清S100β在术前、术毕、术后6 h有差异,NSE在术毕及术后6 h、12 h升高(P<0.05)。 结论 单纯鼾症患者全麻术后出现认知功能受损,但认知功能受损程度仅在血清学指标上有所改变。

关键词: 单纯鼾症, 认知功能, S100β蛋白, NSE, 全身麻醉

Abstract: Objective To assess the correlation between serum S100β protein and serum neuron-specific enolase(NSE)levels before and after general anesthesia in patients with simple snoring(SS)and investigate the effect of general anesthesia on the cognitive function of these patients before and after an operation. Methods Patients undergoing selective arthroscopy surgery under general anesthesia were divided into the SS(AHI<5, n1=30)and normal sleep(n2=30)groups. Pre- and post-operatively, the cognitive function was evaluated using the Montreal Cognitive Assessment(Mo CA)test and the changes in serum S100β and NSE levels were analyzed in the two groups. Results Compared to the preoperative levels, serum S100β and NSE levels in both groups significantly increased at the end of and 6 h and 12 h after surgery(P<0.05). Compared to that of the normal sleep group, there was no significant difference in the Mo CA scores in the SS group(P>0.05). However, levels of serum S100β were different preoperatively and at the end of and 6 h after surgery(P>0.05). NSE levels increased at the end of and 6 h and 12 h after surgery(P>0.05). Conclusion Patients with simple snoring after general anesthesia had impaired cognitive function, but the extent of cognitive impairment was was only reflected by serological changes.

Key words: General anesthesia, Cognitive function, S100β, Simple snoring, NSE

中图分类号: 

  • R766.7
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