PU.1转录因子和辅助性Th9细胞与变应性鼻炎

doi:10.6040/j.issn.1673-3770.0.2018.456

摘要/Abstract

摘要：

变应性鼻炎AR是IgE介导的鼻黏膜的I型变态反应性疾病，既往对AR的认识已由Th1/Th2型细胞因子的不平衡扩展为Th1/Th2/Th17/Treg细胞模式。而近年发现的Th9细胞在变态反应性疾病的发生发展中发挥着重要作用。PU.1是Ets(E26 transformation specific)家族中重要的转录因子，在机体天然免疫、获得性免疫的调节有着重要作用。PU.1的激活则直接影响Th9细胞的发育分化调节及生物学特性。主要总结转录因子PU.1和Th9细胞在变应性鼻炎发病机制中的可能作用。

关键词: 变应性鼻炎, 辅助性T细胞9, 转录因子PU.1, 白细胞介素9

Abstract:

Allergic rhinitis is an IgE-mediated type I allergic disease of the nasal mucosa. Previous knowledge of AR has been extended from the imbalance of Th1/Th2 type cytokines to the Th1/Th2/Th17/Treg cell pattern. The Th9 cells discovered in recent years play an important role in the occurrence and development of allergic diseases. PU.1 is an important transcription factor in the Ets family and plays an important role in the regulation of natural immunity and acquired immunity. The activation of PU.1 directly affects the developmental differentiation and biological characteristics of Th9 cells. This article summarizes the possible roles of transcription factors PU.1 and Th9 cells in the pathogenesis of allergic rhinitis.

Key words: Allergic rhinitis, Helper T cell 9, Transcription factor PU.1, Interleukin-9

中图分类号:

R765.21

刘小涵,张小兵. PU.1转录因子和辅助性Th9细胞与变应性鼻炎[J]. 山东大学耳鼻喉眼学报, 2019, 33(5): 139-143.

Xiaohan LIU,Xiaobing ZHANG. PU.1 transcription factor and helper Th9 cells with allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 139-143.

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