中性粒细胞淋巴细胞比值和血小板淋巴细胞比值对调强放疗鼻咽癌患者的预后价值

doi:10.6040/j.issn.1673-3770.0.2019.357

摘要/Abstract

摘要： 目的研究中性粒细胞淋巴细胞比值(NLR)与血小板淋巴细胞比值(PLR)对鼻咽癌(NPC)调强放疗患者的预后价值。方法回顾性收集2012年6月至2014年1月期间就诊的120例调强放疗鼻咽癌患者的一般临床信息及淋巴细胞、中性粒细胞、血小板计数和生存资料。选择相关性分析、K-M生存分析和Cox多因素回归分析、探讨NLR、PLR与患者总生存时间(OS)、无进展生存时间(PFS)、无远处转移生存时间(DMFS)、局部无复发生存时间(LRF)的关系。结果患者5年OS、PFS、LRF和DFS分别为86.8%、78.3%、94.2%和85.3%,NLR与T期、N期、肿瘤期相关,PLR与T期、肿瘤期相关。NLR是OS、PFS、DMF的独立预后指标。结论 NLR是调强放疗鼻咽癌患者的独立预后因素。

关键词: 中性粒细胞淋巴细胞比值, 血小板淋巴细胞比值, 鼻咽癌, 预后

Abstract: Objective To evaluate the role of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in the prognosis of nasopharyngeal carcinoma(NPC). Methods A total of 120 patients with NPC undergoing intensity modulated radiation therapy(IMRT)from June 2012 to January 2014 were retrospectively included and their clinical information was obtained. The relationship between NLR, PLR, and overall survival(OS), progression-free survival(PFS), distant metastasis-free survival(DMFS), and local recurrence-free survival(LRF)was explored by correlation analysis, survival analysis, and multivariate regression analysis. Results The overall 5-year estimated OS, PFS, LRFS and DFS were 86.8%, 78.3%, 94.2%, and 85.3%, respectively. There was a significant association between NLR and T-stage, N-stage and tumor stage. PLR was also significantly associated with T-stage and tumor stage. NLR was shown to be an independent prognostic indicator for OS, PFS, DMFS. Conclusion NLR is an independent prognostic factor in nasopharyngeal carcinoma patients treated with IMRT.

Key words: Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Nasopharyngeal carcinoma, Prognosis

中图分类号:

R739.6

陈雪松,付伟伟,刘江涛. 中性粒细胞淋巴细胞比值和血小板淋巴细胞比值对调强放疗鼻咽癌患者的预后价值[J]. 山东大学耳鼻喉眼学报, 2020, 34(1): 50-53.

CHEN Xuesong, FU Weiwei, LIU Jiangtao. The prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intensity modulated radiation therapy for nasopharyngeal carcinoma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(1): 50-53.

参考文献

[1] 李晓惠, 徐冰清, 高劲, 等. 中性粒细胞与淋巴细胞比值对鼻咽癌放射敏感性及预后影响的研究[J]. 中华放射肿瘤学杂志, 2016, 25(5): 432-436. doi:10.3760/cma.j.issn.1004-4221. 2016.05.002. LI Xiaohui, XU Bingqing, GAO Jin, et al. Influence of neutrophil-lymphocyte ratio on radiosensitivity and prognosis in patients with nasopharyngeal carcinoma[J]. Chinese Journal of Radiation Oncology, 2016, 25(5): 432-436. doi:10.3760/cma.j.issn.1004-4221. 2016.05.002.
[2] 徐翔, 何庆文, 肖才文. Ki67和衍生中性粒细胞与淋巴细胞比值对鼻咽癌患者的预后评估[J]. 国际肿瘤学杂志, 2018, 45(12): 711-715. doi:10.3760/cma.j.issn.1673-422X. 2018.12.002. XU Xiang. Prognostic evaluation of Ki67 and derived neutrophil-lymphocyte ratio in patients with nasopharyngeal carcinoma[J]. Journal of International Oncology, 2018, 45(12): 711-715. doi:10.3760/cma.j.issn.1673-422X. 2018.12.002.
[3] Lee AWM, Ma BBY, Ng WT, et al. Management of nasopharyngeal carcinoma: current practice and future perspective[J]. J Clin Oncol, 2015, 33(29): 3356-3364. doi:10.1200/jco. 2015.60.9347.
[4] 郑乃莹, 林先桃, 邵汛帆, 等. 吸烟与Ⅲ~ⅣA期鼻咽癌预后关系[J]. 中华肿瘤防治杂志, 2017, 24(16): 1113-1118. doi:10.16073/j.cnki.cjcpt. 2017.16.002. ZHENG Naiying, LIN Xiantao, SHAO Xunfan, et al. Relationship between smoking and prognosis of Ⅲ/ⅣA stage nasopharyngeal carcinoma[J]. Chinese Journal of Cancer Prevention and Treatment, 2017, 24(16): 1113-1118. doi:10.16073/j.cnki.cjcpt. 2017.16.002.
[5] 胡望远, 姜峰, 杨昕, 等. 鼻咽癌调强放疗计划后剂量分布与预后相关性研究[J]. 肿瘤学杂志, 2018, 24(8): 828-831. doi:10.11735/j.issn.1671-170X. 2018.08.B015. HU Wangyuan, JIANG Feng, YANG Xin, et al. The effect of post intensity-modulated radiotherapy dose distribution on prognosis of nasopharyngeal carcinoma[J]. Journal of Chinese Oncology, 2018, 24(8): 828-831. doi:10.11735/j.issn.1671-170X. 2018.08.B015.
[6] Lu C, Gao P, Yang YC, et al. Prognostic evaluation of platelet to lymphocyte ratio in patients with colorectal cancer[J]. Oncotarget, 2017, 8(49): 86287-86295. doi:10.18632/oncotarget. 21141.
[7] 马涛, 刘斌, 刘丽霞, 等. 局部复发鼻咽癌调强放疗的临床结果和预后因素分析[J]. 河北医药, 2016, 38(14): 2185-2187. doi:10.3969/j.issn.1002-7386. 2016.14.031.
[8] Chua ML, Tan SH, Kusumawidjaja G, et al. Neutrophil-to-lymphocyte ratio as a prognostic marker in locally advanced nasopharyngeal carcinoma: A pooled analysis of two randomised controlled trials[J]. Eur J Cancer, 2016, 67: 119-129. doi:10.1016/j.ejca. 2016.08.006.
[9] 王勇, 吴波, 孙华丽, 等. 鼻咽癌EGFR、HLA-F表达水平及调强放疗预后的影响因素分析[J]. 浙江医学, 2019, 41(17): 1826-1830. doi:10.12056/j.issn.1006-2785.2019.41.17. 2018-2721. WANG Yong, WU Bo, SUN Huali, et al. Expression of EGFR and HLA-F in nasopharyngeal carcinoma and their prognostic value[J]. Zhejiang Medical Journal, 2019, 41(17): 1826-1830. doi:10.12056/j.issn.1006-2785. 2019.41.17. 2018-2721.
[10] Lu AY, Li HF, Zheng YM, et al. Prognostic significance of neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, and platelet to lymphocyte ratio in patients with nasopharyngeal carcinoma[J]. Biomed Res Int, 2017, 2017: 1-6. doi:10.1155/2017/3047802.
[11] Jin Y, Ye X, He CX, et al. Pretreatment neutrophil-to-lymphocyte ratio as predictor of survival for patients with metastatic nasopharyngeal carcinoma[J]. Head Neck, 2015, 37(1): 69-75. doi:10.1002/hed.23565.
[12] 宗井凤, 郑瑜宏, 翁友良, 等. 治疗前血浆EBV DNA在调强放疗鼻咽癌患者预后中的意义[J]. 肿瘤学杂志, 2016, 22(10): 810-815. doi:10.11735/j.issn.1671-170X. 2016.10.B007. ZONG Jingfeng, ZHENG Yuhong, WENG Youliang, et al. Prognostic value of pre-treatment plasma EBV DNA in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy[J]. Journal of Chinese Oncology, 2016, 22(10): 810-815. doi:10.11735/j.issn.1671-170X. 2016.10.B007.
[13] 许梅杰, 苏梅, 薛荣, 等. 阻塞性睡眠呼吸暂停程度与中性粒细胞/淋巴细胞比值的相关性研究[J]. 山东大学耳鼻喉眼学报, 2016, 30(5): 33-37. XU Meijie, SU Mei, XUE Rong, et al. Correlation between neutrophil/lymphocyte ratio and severity of obstructive sleep apnea syndrome[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2016, 30(5): 33-37.
[14] Young CA, Murray LJ, Karakaya E, et al. The prognostic role of the neutrophil-to-lymphocyte ratio in oropharyngeal carcinoma treated with chemoradiotherapy[J]. Clin Med Insights Oncol, 2014, 8: 81-86. doi:10.4137/CMO. S15476.
[15] Farhan-Alanie OM, Mc Mahon J, Mc Millan DC. Systemic inflammatory response and survival in patients undergoing curative resection of oral squamous cell carcinoma[J]. Br J Oral Maxillofac Surg, 2015, 53(2): 126-131. doi:10.1016/j.bjoms. 2014.10.007.
[16] Selzer E, Grah A, Heiduschka G, et al. Primary radiotherapy or postoperative radiotherapy in patients with head and neck cancer: Comparative analysis of inflammation-based prognostic scoring systems[J]. Strahlenther Onkol, 2015, 191(6): 486-494. doi:10.1007/s00066-014-0803-1.
[17] 张劼, 龚齐. 不同分型慢性鼻-鼻窦炎患者外周血嗜酸性粒细胞与中性粒细胞百分比及变态反应临床差异性分析[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 54-57. doi:10.6040/j.issn.1673-3770.0. 2017.422. ZHANG Jie, GONG Qi. Clinical significance of eosinophils and neutrophils in blood and allergic reaction in patients with chronic rhinosinusitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(3): 54-57. doi:10.6040/j.issn.1673-3770.0. 2017.422.

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