山东大学耳鼻喉眼学报 ›› 2020, Vol. 34 ›› Issue (2): 67-71.doi: 10.6040/j.issn.1673-3770.1.2020.010

• 临床研究 • 上一篇    下一篇

准分子激光表层切削手术的疗效及其现存问题

崔歌,姜洋综述李莹审校   

  1. 中国医学科学院/北京协和医院 眼科, 北京 100730
  • 发布日期:2020-04-07
  • 通讯作者: 姜洋. E-mail:jiangyangpumch@126.com

The efficacy and disadvantages of three excimer laser surface cutting surgeries

CUI Ge, JIANG YangOverview,LI YingGuidance   

  1. Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Published:2020-04-07

摘要: 当代准分子激光手术包括板层切削手术和表层切削手术,表层切削手术的优点在于无瓣相关并发症、术后生物力学较稳定,但有术后疼痛明显、角膜上皮下雾状混浊(haze)、糖皮质激素需要使用时间长、屈光回退等不足。表层切削手术主要有TransPRK、LASEK、Epi-LASIK PRK,其中TransPRK真正实现无接触操作,上皮和基质切削一步到位,以其更精确的切削而被广泛看好。如今表层手术渐有回归的趋势,其术后疼痛、haze、屈光回退是三个需要重点讨论的问题。

关键词: 准分子激光表层切削手术, TransPRK, 疼痛, haze, 屈光回退

Abstract: Contemporary excimer laser surgery includes both stoma and surface cutting surgeries. The advantages of surface cutting surgery are stable postoperative biomechanics and no flap related complications. However, the disadvantages include postoperative pain, haze under the corneal epithelium, long term use of glucocorticoids, and refractive regression. Surface cutting operations include photorefractive keratectomy(PRK), TransPRK, laser-assisted sub-epithelial keratectomy(LASEK), and Epi-laser assisted in-situ keratomileusis(Epi-LASIK). Of these, TransPRK is a truly contactless operation and involves only one set of epithelial and matrix cutting. The procedure is widely favored due to the ability to make more accurate cuts. Complications such as postoperative pain, haze, and retractive regression are the three most common complications after surface cutting surgery.

Key words: Excimer laser surface cutting surgery, TransPRK, Pain, haze, Refractive regression

中图分类号: 

  • R778
[1] Schallhorn SC, Amesbury EC, Tanzer DJ. Avoidance, recognition, and management of LASIK complications[J]. Am J Ophthalmol, 2006, 141(4): 733-739. doi:10.1016/j.ajo.2005.11.036.
[2] Ambrósio R Jr, Dawson DG, Salomão M, et al. Corneal ectasia after LASIK despite low preoperative risk: tomographic and biomechanical findings in the unoperated, stable, fellow eye[J]. J Refract Surg, 2010, 26(11): 906-911. doi:10.3928/1081597X-20100428-02.
[3] Fontes BM, Ambrósio R Jr, Alonso RS, et al. Corneal biomechanical metrics in eyes with refraction of -19.00 to +9.00 D in healthy Brazilian patients[J]. J Refract Surg, 2008, 24(9): 941-945. doi:10.3928/1081597X-20081101-14.
[4] 中华医学会眼科学分会角膜病学组. 激光角膜屈光手术临床诊疗专家共识(2015年)[J]. 中华眼科杂志, 2015, 51(4): 249-254. doi:10.3760/cma.j.issn.0412-4081.2015.04.003.
[5] Chauvin L, Goupille C, Blanc C, et al. Long chain n-3 polyunsaturated fatty acids increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt and PKCε/δ-induced ERK pathways[J]. Biochim Biophys Acta, 2016, 1861(4): 380-390. doi:10.1016/j.bbalip.2016.01.012.
[6] 周跃华. 重视准分子激光角膜屈光手术方式的精准个性化选择[J]. 中华实验眼科杂志, 2019, 37(7): 497-500. ZHOU Yuehua. Importance of the precise and personalized selection of laser corneal refractive surgery[J]. Chinese Journal of Experimental Ophthalmology, 2019, 37(7): 497-500.
[7] 中华医学会眼科学分会眼视光学组. 中国经上皮准分子激光角膜切削术专家共识(2019年)[J]. 中华眼科杂志, 2019, 55(3): 169-173. doi:10.3760/cma.j.issn.0412-4081.2019.03.003.
[8] 周行涛. 表层切削的适应证和技术规范[J]. 中国眼耳鼻喉科杂志, 2008, 8(6): 344-347. doi:10.3969/j.issn.1671-2420.2008.06.002. ZHOU Xingtao. Application and technique of surface ablation[J]. Chinese Journal of Ophthalmology and Otorhinolaryngology, 2008, 8(6): 344-347. doi:10.3969/j.issn.1671-2420.2008.06.002.
[9] 徐婧, 李莹, 王忠海, 等. 经上皮准分子激光角膜切削术治疗近视的临床疗效[J]. 中华眼视光学与视觉科学杂志, 2015, 17(12): 717-721. doi:10.3760/cma.j.issn.1674-845X.2015.12.004. XU Jing, LI Ying, WANG Zhonghai, et al. Clinical results of transepithelial photorefractive keratectomy for myopia[J]. Chinese Journal of Optometry Ophthalmology and Visual Science, 2015, 17(12): 717-721. doi:10.3760/cma.j.issn.1674-845X.2015.12.004.
[10] Aslanides IM, Georgoudis PN, Selimis VD, et al. Single-step transepithelial ASLA(SCHWIND)with mitomycin-C for the correction of high myopia: long term follow-up[J]. Clin Ophthalmol, 2015, 9: 33-41. doi:10.2147/OPTH.S73424.
[11] Wen DZ, Tu RX, Flitcroft I, et al. Corneal surface ablation laser refractive surgery for the correction of myopia: a network meta-analysis[J]. J Refract Surg, 2018, 34(11): 726-735. doi:10.3928/1081597X-20180905-01.
[12] Yuksel N, Bilgihan K, Hondur AM, et al. Long term results of Epi-LASIK and LASEK for myopia[J]. Cont Lens Anterior Eye, 2014, 37(3): 132-135. doi:10.1016/j.clae.2013.09.005.
[13] Reilly CD, Panday V, Lazos V, et al. PRK vs LASEK vs Epi-LASIK: a comparison of corneal haze, postoperative pain and visual recovery in moderate to high myopia[J]. Nepal J Ophthalmol, 2010, 2(2): 97-104. doi:10.3126/nepjoph.v2i2.3715.
[14] Kulkarni SV, AlMahmoud T, Priest D, et al. Long-term visual and refractive outcomes following surface ablation techniques in a large population for myopia correction[J]. Invest Ophthalmol Vis Sci, 2013, 54(1): 609-619. doi:10.1167/iovs.12-10387.
[15] 王璐, 王雁. 角膜表层屈光手术后疼痛控制的研究进展[J]. 中华眼视光学与视觉科学杂志, 2014, 16(1): 57-60, 64. doi:10.3760/cma.j.issn.1674-845X.2014.01.014. WANG Lu, WANG Yan. Current progress in pain control after corneal surface ablation[J]. Chinese Journal of Optometry Ophthalmology and Visual Science, 2014, 16(1): 57-60, 64. doi:10.3760/cma.j.issn.1674-845X.2014.01.014.
[16] 王忠海, 姜洋, 张庆生, 等. 经上皮准分子激光角膜切削术与准分子激光上皮下角膜磨镶术治疗近视眼的临床效果比较[J]. 中华眼科杂志, 2019, 55(2): 122-126. doi:10.3760/cma.j.issn.0412-4081.2019.02.010. WANG Zhonghai, JIANG Yang, ZHANG Qingsheng, et al. Clinical outcomes after laser epithelial keratomileusis(LASEK)and transepithelial photorefractive keratectomy(TPRK)in myopia[J]. Chinese Journal of Ophthalmology, 2019, 55(2): 122-126. doi:10.3760/cma.j.issn.0412-4081.2019.02.010.
[17] 崔长霞, 陶祥臣, 朱伟. 表层角膜屈光手术后疼痛及角膜刺激症状的观察[J]. 山东大学耳鼻喉眼学报, 2015, 29(6): 60-63. CUI Changxia, TAO Xiangchen, ZHU Wei. Postoperative pain and corneal irritation after surface corneal refractive surgery[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2015, 29(6): 60-63.
[18] Torres LF, Sancho C, Tan B, et al. Early postoperative pain following Epi-LASIK and photorefractive keratectomy: a prospective, comparative, bilateral study[J]. J Refract Surg, 2007, 23(2): 126-132.
[19] Celik U, Bozkurt E, Celik B, et al. Pain, wound healing and refractive comparison of mechanical and transepithelial debridement in photorefractive keratectomy for myopia: results of 1 year follow-up[J]. Cont Lens Anterior Eye, 2014, 37(6): 420-426. doi:10.1016/j.clae.2014.07.001.
[20] Choi CY, Kim JY, Kim MJ, et al. Transmission Electron microscopy study of corneal epithelial flaps following removal using mechanical scraping, alcohol, and epikeratome techniques[J]. J Refract Surg, 2008, 24(7): 667-670. doi:10.3928/1081597X-20080901-05.
[21] 韩伟, 郝俊华, 任延军. LASEK手术中上皮瓣的完整性与haze的关系[J]. 河北医药, 2012, 34(18): 2789-2790. doi:10.3969/j.issn.1002-7386.2012.18.035.
[22] Lin N, Yee SB, Mitra S, et al. Prediction of corneal haze using an ablation depth/corneal thickness ratio after laser epithelial keratomileusis[J]. J Refract Surg, 2004, 20(6): 797-802.
[23] 陈跃国. 准分子激光角膜屈光手术专家释疑[M]. 北京: 人民卫生出版社, 2007: 108-110.
[24] Tuft SJ, Gartry DS, Rawe IM, et al. Photorefractive keratectomy: implications of corneal wound healing[J]. Br J Ophthalmol, 1993, 77(4): 243-247. doi:10.1136/bjo.77.4.243.
[25] Sia RK, Coe CD, Edwards JD, et al. Visual outcomes after Epi-LASIK and PRK for low and moderate myopia[J]. J Refract Surg, 2012, 28(1): 65-71. doi:10.3928/1081597X-20111004-01.
[26] Liu MN, Gao H, Shi WY. Factors affecting myopic regression after laser in situ keratomileusis and laser-assisted subepithelial keratectomy for high myopia[J]. Semin Ophthalmol, 2019, 34(5): 359-364. doi:10.1080/08820538.2019.1632353.
[27] Lim SA, Park Y, Cheong YJ, et al. Factors affecting long-term myopic regression after laser in situ keratomileusis and laser-assisted subepithelial keratectomy for moderate myopia[J]. Korean J Ophthalmol, 2016, 30(2): 92-100. doi:10.3341/kjo.2016.30.2.92.
[28] Aslanides IM, Georgoudis PN, Selimis VD, et al. Single-step transepithelial ASLA(SCHWIND)with mitomycin-C for the correction of high myopia: long term follow-up[J]. Clin Ophthalmol, 2015, 9: 33-41. doi:10.2147/OPTH.S73424.
[29] Kang DSY, Kim SW. Effect of corneal cross-linking on epithelial hyperplasia and myopia regression after transepithelial photorefractive keratectomy[J]. J Refract Surg, 2019, 35(6): 354-361. doi:10.3928/1081597X-20190422-01.
[30] Nakamura Y, Hieda O, Yamamura K, et al. Comparative study of seven-year outcomes following laser in situ keratomileusis with those of trans-epithelial photorefractive keratectomy[J]. Nippon Ganka Gakkai Zasshi, 2016, 120(7): 487-493.
[31] Mehlan J, Linke SJ, Skevas C, et al. Safety and complications after three different surface ablation techniques with mitomycin C: a retrospective analysis of 2757 eyes[J]. Albrecht Von Graefes Arch Fur Klinische Und Exp Ophthalmol, 2019, 257(1): 217-223. doi:10.1007/s00417-018-4077-7.
[32] 张月强, 高雅晴, 褚慧, 等. 经上皮准分子激光角膜切削术治疗低中度近视术后中央角膜上皮厚度的变化[J]. 中华眼视光学与视觉科学杂志, 2019, 21(3): 217-222. doi:10.3760/cma.j.issn.1674-845X.2019.03.011. ZHANG Yueqiang, GAO Yaqing, CHU Hui, et al. Changes in central corneal epithelial thickness after transepithelial photorefractive keratectomy for low and moderate myopia[J]. Chinese Journal of Optometry Ophthalmology and Visual Science, 2019, 21(3): 217-222. doi:10.3760/cma.j.issn.1674-845X.2019.03.011.
[1] 张静祎,王文一,荣凌燕,张家奎,宋西成. 中药热奄包外敷联合七叶皂苷钠静滴治疗鼻部外伤肿胀疗效观察[J]. 山东大学耳鼻喉眼学报, 2020, 34(6): 21-26.
[2] 马驰,郑桂彬,孙海清,吴国长,郭雅文,孔杨,宋西成,郑海涛. 加速康复外科理念应用于甲状腺癌手术100例[J]. 山东大学耳鼻喉眼学报, 2020, 34(3): 107-110.
[3] 岳沙利,邓应平. 有晶体眼后房型人工晶体植入术矫正RK术后屈光回退一例[J]. 山东大学耳鼻喉眼学报, 2020, 34(2): 85-87.
[4] 徐磊,朱鹃芬,程雷. 成年人扁桃体切除术三种手术方式的临床比较[J]. 山东大学耳鼻喉眼学报, 2016, 30(6): 49-52.
[5] 庞宇峰,龚静蓉,邹阳,黄娟. 改良自制鼻咽通气管在FESS术后填塞中的应用[J]. 山东大学耳鼻喉眼学报, 2016, 30(1): 47-50.
[6] 崔长霞, 陶祥臣, 朱伟. 表层角膜屈光手术后疼痛及角膜刺激症状的观察[J]. 山东大学耳鼻喉眼学报, 2015, 29(6): 60-63.
[7] 周敬淳, 柯朝阳, 马玲国, 张菁菁, 张伟, 冯春英. 等离子射频消融术与常规剪切术治疗会厌囊肿疗效比较[J]. 山东大学耳鼻喉眼学报, 2014, 28(6): 43-46.
[8] 张杰, 李进让, 刘涛. 吞咽表面肌电图评估扁桃体切除术后患者疼痛程度的可能性研究[J]. 山东大学耳鼻喉眼学报, 2014, 28(6): 57-60.
[9] 余鹏举1,许风雷2,江满杰2. 鼻内镜治疗难治性鼻出血121例疗效分析[J]. 山东大学耳鼻喉眼学报, 2013, 27(4): 4-5.
[10] 于海群1,陶祥臣2,朱伟3,原越4,张泳2. 丝裂霉素C对LASEK术后Haze形成及角膜基质细胞的影响[J]. 山东大学耳鼻喉眼学报, 2012, 26(5): 3-4.
[11] 林庆强,陈缪安,蔡志良,温晗光. 喉结核诊疗分析36例[J]. 山东大学耳鼻喉眼学报, 2012, 26(1): 48-49.
[12] 伍红良1,高延永1,庾俊雄2, 陶赞英3,刘强和1,何晓松1,耿宛平1. 经鼻内镜鼻窦术后自控静脉镇痛对血浆IL-6、IL-10的影响[J]. 山东大学耳鼻喉眼学报, 2011, 25(4): 44-47.
[13] 梁辉1,潘新良1,王启荣2,韩飞2,崔朝阳2,于淑东2. 地塞米松在成人扁桃体切除术后镇痛中的应用研究[J]. 山东大学耳鼻喉眼学报, 2010, 24(01): 65-.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 张晗,黄一飞 . 抗角膜移植排斥的研究进展[J]. 山东大学耳鼻喉眼学报, 2006, 20(1): 84 -87 .
[2] 牛善利,柴茂文,李振秀 . 鼻内镜下鼻甲成形术治疗慢性肥厚性鼻炎60例[J]. 山东大学耳鼻喉眼学报, 2006, 20(1): 16 -18 .
[3] 孟庆国,卢永田,范献良 . 杀伤细胞免疫球蛋白样受体基因多态性与鼻咽癌的关联性[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 196 -199 .
[4] 马玉起,孔祥春 . 先天性双侧下唇窦道1例[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 199 -199 .
[5] 万俐佳,鲁海涛,姜义道,刘 辉,李 琴,佘腊枝 . 改良腭咽成形术治疗阻塞性睡眠呼吸暂停综合征41例[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 204 -205 .
[6] 于青青 ,王跃建 . 硬质耳内镜的临床应用进展[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 222 -224 .
[7] 吉晓滨,邓家德,臧林泉,王 磊,谢 军 . 豚鼠变应性鼻炎模型血清组胺的测定[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 228 -230 .
[8] 向登,卢永田,孙焕吉 . 鼻内镜下修补脑脊液鼻漏19例并文献复习[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 234 -236 .
[9] 邱恩惠,李志春,方文旭 . 嗅觉障碍的中西医治疗[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 253 -257 .
[10] 殷国华,钟 笑 . 激光减容术治疗舌扁桃体肥大的远期疗效[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 280 -282 .