阻塞性睡眠呼吸暂停与肿瘤相关性进展

doi:10.6040/j.issn.1673-3770.0.2019.595

摘要/Abstract

摘要： 阻塞性睡眠呼吸暂停(OSA)作为一种世界流行的慢性疾病,近年来其发生率逐年增加。OSA的主要特点是上气道反复塌陷,由此引起反复的呼吸暂停、低通气和频繁血氧饱和度下降,进而引发睡眠片段化、睡眠结构紊乱,患者通常伴有白天嗜睡、注意力不集中等。长期的睡眠片段化和微觉醒状态与许多慢性疾病结局相关,比如高血压、心肌梗死、2型糖尿病、阿尔兹海默病等。另外,OSA还与肿瘤密切相关。随着OSA和低氧血症严重程度的增加,相关的多种肿瘤的发生率与死亡率也增加,如肺癌、乳腺癌、鼻咽癌、前列腺癌、中枢神经系统的肿瘤等。论文对阻塞性睡眠呼吸暂停的概况、与肿瘤相关的统计学证据进行综述,并讨论了OSA与肿瘤相关的分子机制、治疗等方面的内容,旨在为阻塞性睡眠呼吸暂停与肿瘤的相关研究及临床实践提供参考依据,为进一步研究治疗方法提供新思路。

关键词: 阻塞性睡眠呼吸暂停, 低氧血症, 肿瘤, 相关性

Abstract: Obstructive sleep apnea(OSA)is a chronic disease that is prevalent worldwide. The morbidity of OSA has increased year by year. The primary characteristic of OSA is repeated upper airway collapse, which causes recurrent apnea, hypopnea, and frequent decline of the oxyhemoglobin saturation. This leads to sleep fragmentation and sleep structure disorder. Patients with OSA usually suffer from daytime sleepiness and inattention. Long-term sleep fragmentation and micro-arousal state are related to many chronic diseases, such as hypertension, myocardial infarction, Type 2 diabetes and Alzheimer's disease. Moreover, OSA is also closely related to tumors. With increases in the degree of OSA and hypoxemia, the incidence and mortality of related tumors have also gone up. Such tumors include lung, breast, nasopharyngeal, prostate and central nervous system cancers. To provide a reference for OSA and tumor-related research and clinical practice and develop ideas around further treatment research that could be conducted, this article reviews the profile of OSA and the statistical evidence, moreover, the molecular mechanism and treatment of OSA related to tumors will be discussed.

Key words: Obstructive sleep apnea, Hypopnea, Tumor, Correlation

中图分类号:

R766.7

聂帅,崔宇杰,刘岩,文连姬. 阻塞性睡眠呼吸暂停与肿瘤相关性进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(5): 152-156.

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