慢性鼻窦炎中上皮间质转化信号转导通路及其他相关因子的研究进展

doi:10.6040/j.issn.1673-3770.0.2021.581

摘要/Abstract

摘要： 慢性鼻窦炎是多种因素导致的鼻腔鼻窦黏膜慢性炎症性疾病。其发病机制及其病理生理过程尚不明确。上皮间质转化是鼻窦黏膜组织重塑的重要环节,而组织重塑在慢性鼻窦炎发生、发展中起到重要作用。现有的研究表明不同类型的慢性鼻窦炎发生上皮间质转化的特点存在差异。现将近年来慢性鼻窦炎黏膜上皮间质转化相关信号转导通路的研究进展及一些其他相关因子的研究作一综述。

关键词: 慢性鼻窦炎, 上皮间质转化, 信号转导通路

Abstract: Chronic rhinosinusitis is a chronic inflammatory disease of the nasal cavity and sinus mucosa. Although it can be caused by many factors, its pathogenesis and pathophysiological process remain unknown. Epithelial-mesenchymal transformation has been found to be an important factor in mucosal tissue remodeling of the nasal sinus and development of chronic rhinosinusitis. Furthermore, studies have shown that different types of chronic rhinosinusitis have different characteristics of epithelial-mesenchymal transformation. This article reviews recent research progress on the study of signal transduction pathways and other factors related to epithelial-mesenchymal transformation in chronic rhinosinusitis.

Key words: Chronic rhinosinusitis, Epithelial-mesenchymal transformation, Signal transduction pathway

中图分类号:

R765.41

乔新杰,赵玉林. 慢性鼻窦炎中上皮间质转化信号转导通路及其他相关因子的研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 71-77.

QIAO Xinjie,. Research progress on the signal transduction pathway and other factors related to epithelial-mesenchymal transformation in chronic rhinosinusitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 71-77.

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