山东大学耳鼻喉眼学报 ›› 2025, Vol. 39 ›› Issue (5): 118-124.doi: 10.6040/j.issn.1673-3770.0.2024.364

• 综述 • 上一篇    

基于肠道屏障-内耳轴信号通路假说下高脂饮食对听力受损研究进展

胡楠1,黄韵烨2,刘静3,许芝彬4   

  1. 1.暨南大学附属第一医院 胃肠外科减重中心, 广东 广州 510630;
    2.暨南大学附属第一医院 耳鼻喉头颈外科, 广东 广州 510630;
    3.贵州省大方县人民医院 耳鼻喉科, 贵州 毕节 551699;
    4.广州医科大学附属第一医院 广州呼吸健康研究院/国家呼吸医学中心/国家呼吸疾病临床研究中心/呼吸疾病国家重点实验室器官移植科, 广东 广州 510120
  • 发布日期:2025-09-19
  • 通讯作者: 许芝彬. E-mail:unignorable_xuzhibin@outlook.com
  • 基金资助:
    广东省自然科学基金-面上项目(2022A1515012217);广州市临床特色技术项目(2023C-TS17)

Research progress on high fat diets and hearing loss based on the gut barrier- inner ear axis hypothesis

HU Nan1, HUANG Yunye2, LIU Jing3, XU Zhibin4   

  1. 1. Weight Loss Center of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong, China2. Department of Otolaryngology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong, China3. Department of Otolaryngology, Dafang People's Hospital, Bijie 551699, Guizhou, China4. Department of Organ Transplantation, National Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong, China
  • Published:2025-09-19

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摘要： 肥胖引发的并发症逐渐成为公共卫生的重点关注问题。除了心血管疾病等已知并发症外,肥胖与听力功能损害之间的正相关性特别是在高体质量指数人群中更为显著,未来仍需大量研究进一步推导验证早期干预和生活方式的改变是否能够降低听力损失的风险。高脂饮食作为肥胖症的重要诱因之一,可能存在未充分了解的机制影响听力。本文通过探讨高脂饮食如何通过破坏肠道屏障进而影响听力功能,对肠道屏障-内耳轴信号通路功能假说来进行综述。通过综合流行病学数据、动物实验和临床试验结果,深入分析高脂饮食导致的肠道菌群变化、肠道屏障功能损伤与听力下降之间的关联性。此研究结果不仅揭示肠道健康与听力之间的潜在联系,也为进一步理解生活方式因素如何通过肠道微生态系统影响远端器官功能提供新视角,对于促进跨学科研究、开发新的预防和治疗听力损失的策略具有借鉴意义。

关键词: 肥胖症, 肠道菌群, 听力功能, 肠道屏障, 高脂饮食

Abstract: Obesity-related complications have become an increasingly important public health concern. In addition to well-known co-morbidities such as cardiovascular disease, recent research has shown a positive association between obesity and hearing impairment, which is more pronounced in individuals with a high body mass index. This finding highlights the need for further research to explore whether early intervention and lifestyle changes can reduce the risk of hearing loss. As a major contributor to obesity, a high-fat diet may involve mechanisms affecting hearing that are not yet fully understood. This review aims to investigate how a high-fat diet disrupts the gut barrier and subsequently affects hearing function, proposing and evaluating the gut barrier-internal ear axis hypothesis. By synthesising epidemiological data, animal experiments and clinical trial results, this review analyses in depth the links between high-fat diet-induced changes in gut microbiota, gut barrier dysfunction and hearing loss. The findings not only reveal potential links between gut health and hearing function, but also provide new insights into how lifestyle factors can influence distant organ function through the gut microbiome. This understanding has significant implications for promoting interdisciplinary research and developing novel strategies for the prevention and treatment of hearing loss.

Key words: Obesity, Intestinal flora, Hearing function, Intestinal barrier, High-fat diet

中图分类号: 

  • R735.7
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