J Otolaryngol Ophthalmol Shandong Univ ›› 2013, Vol. 27 ›› Issue (4): 62-65.doi: 10.6040/j.issn.1673-3770.0.2013.209

• Articles • Previous Articles     Next Articles

Correlation analysis of VEGF expression and the content of dendritic cells in nasopharyngeal carcinoma and its clinical significance

MIAO Bei-ping1，  ZHANG Rui-shi2，  GUO Zhi-hong3，  SUN Huan-ji1，  MENG Qing-guo1， WANG Xiao-bin1   

  1. 1. Department of Otolaryngology Head & Neck Surgery， Shenzhen Second People′s Hospital, First Affiliated Hospital of Shenzhen University， Shenzhen 518035, Guangdong， China； 2. Department of Ophthalmology， Shenzhen Second People′s Hospital, The First affiliated Hospital of Shenzhen University   Shenzhen 518035, Guangdong  China; 3. Shenzhen Luohu Hospital of Traditional Chinese Medicine, Shenzhen 518000, Guangdong, China
  • Received:2013-07-07 Published:2013-08-16

PDF (PC)

549

Abstract:

Objective    To investigate the correlation between VEGF expression and the content of dendritic cells in nasopharyngeal carcinoma.  Methods    25 cases of nasopharyngeal carcinoma and 25 cases of nasopharyngeal lymphoid tissue were collected. The expressions of VEGF in the nasopharyngeal carcinoma and nasopharyngeal lymphoid tissues were detected by ELISA. The content of dendritic cells and regulatory T cells in the nasopharyngeal carcinoma and nasopharyngeal lymphoid tissues were detected by flow cytometry.  Then the correlation between VEGF expression and the content of dendritic cells was analyzed. Results     Expression of VEGF in nasopharyngeal carcinoma was higher than that in nasopharyngeal lymphoid tissues (t=12.324,P<0.01); the content of CD4+ lymphocyte in nasopharyngeal carcinoma was lower than that in nasopharyngeal lymphoid tissues(t=14.304, P<0.01). While the content of CD4+CD25+ regulatory T cells in nasopharyngeal carcinoma was higher than that in nasopharyngeal lymphoid tissues, and the difference was statistically significant(t=5.910, P<0.01). The content of CD123+ dendritic cells in nasopharyngeal carcinoma was lower than that in nasopharyngeal lymphoid tissues, and the difference was statistically significant(t=7.866, P<0.01). The content of CD11c+ dendritic cells in nasopharyngeal carcinoma was lower than that in nasopharyngeal lymphoid tissues, and the difference was statistically significant(t=3.411, P<0.01). The expression of VEGF was positively correlated with the content of CD4+CD25+ lymphocytes in nasopharyngeal carcinoma(r=0.966, P<0.01), and negatively correlated with the content of CD123+ dendritic cells (r= -0.946, P<0.01) and negatively correlated with the content of CD11c+ dendritic cells(r=-0.954, P<0.01). Conclusion    Expression of VEGF is related to the content of CD4+CD25+ regulatory T cells and the content of dendritic cells in nasopharyngeal carcinoma, which may engage in the immune escape of nasopharyngeal carcinoma.

Key words: Nasopharyngeal carcinoma, Dendritic cells, Regulatory T cells, Vascular endothelial growth factor

CLC Number: 

  • R739.62
[1] LI Hao, LI Yanzhong, WANG Yan. Hypoxia inducible factor-1 alpha and vascular endothelial growth factor expression in the soft palate of [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 43-47.
[2] ZHANG Caixia, LIU Yangyun, JIANG Wen, LIU Gengxun, CAO Hang, CHEN Qiong, ZHANG Jishuai. Investigation of chemosensitization induced by nitric oxide on nasopharyngeal carcinoma CNE-2 cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 72-78.
[3] ZHOU Yibo, GONG Xiaorong, YU Feng. Effects of miR-150 targeted to Nanog on proliferation and invasion of nasopharyngeal carcinoma side population cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 79-84.
[4] WANG Cui, YAN Xin, ZHAO Bojun. Combination of intravitreal ranibizumab with photodynamic therapy in the treatment of wet age-related macular degeneration. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 94-97.
[5] DU Zhihong. Application of oro-nasal combination approach under electronic nasopharyngoscope in the nasopharyngeal biopsy. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 117-118.
[6] . Effects of concurrent chemotherapy and radiotherapy on the quality of life in children and adolescents with nasopharyngeal carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(2): 55-58.
[7] . Construction of c-Met target chimeric antigen receptor T cells and evaluation the role on nasopharyngeal carcinoma cells. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(2): 49-54.
[8] . Effects of PGMS on the expression of vascular endothelial growth factor in the rat of diabetic retinopathy. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(2): 90-95.
[9] . Efficacy of recombinant human epidermal growth factor in prevention of radioactive oral mucosa inflammation and acute radiation dermatitis for nasopharyngeal carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(1): 95-99.
[10] WANG Yaning, GENG Bo, LI Baiyan, CUI Chaoyang, WANG Qirong. The treatment experience on osteoradionecrosis of skull base with nasopharyngeal carcinoma after radiotherapy. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 42-45.
[11] LIU Ye, SUN Dianshui, YIN Jinjun, XIA Ming, XU Ying, SUN Jianhua. Vestibular function damage mechanisms in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 14-17.
[12] WANG Junying, LI Xiaofeng. Effect of deproteinized extract of calf blood gel eye on the injury of corneal endothelial cells after nasopharyngeal carcinoma radiotherapy. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(1): 76-79.
[13] ZHAO Yanlian, LU Yongtian, YANG Jihong, ZHANG Juan, MIAO Fangfang, LI Jieping. Relationship between the expression of EGFL7 in nasopharyngeal carcinoma and the invasion and metastasis of tumor [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(6): 31-35.
[14] LI Yingying, ZHOU Han, ZHANG Weiqiang, DONG Weida. Effects of silencing hypoxia inducible factor-1α on the expression of cytokines in cultured human nasal epithelial cells [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(5): 38-42.
[15] CHE Juan, ZHAO Hongchun, LI Jinling, WANG Yanfei. The relationship between D-Dimer and nasopharyngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(5): 47-49.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd