JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (3): 43-45.doi: 10.6040/j.issn.1673-3770.0.2014.215

Previous Articles     Next Articles

Expressions of S-100 protein and HLA-DR in nasal polyps

JIANG Haihua   

  1. Department of Otolaryngology, Yantai Hospital Affiliated to Binzhou Medical University, Yantai 264100, Shandong, China
  • Received:2014-06-24 Revised:2015-05-08 Published:2015-06-16

PDF (PC)

265

Abstract: Objective To explore the expressions of S-100 protein and HLA-DR in nasal polyps, so as to investigate the immune reaction mediated by the two mechanism of action in the pathogenesis of nasal polyps before and after glucocorticoid treatment. Methods From November 2010 to June 2012, 74 cases of nasal polyp were treated by endoscopy in our department, of them, 37 cases were treated with hormone and 37 cases were treated without. 21 cases of inferior turbinate mucosa taken from patients treated by Deviation of nasal septum served as the control group. Results Expressions of S-100 protein and HLA-DR in the nasal polyp tissues were significantly higher than those in the control group, and they were significantly higher in the treatment group than in the hormone 5 days treatment group (P<0.05). Conclusion In the nasal polyp tissues, high expressions of S 100 protein and HLA-DR suggest that the immune response mediated by the two play an important role in the pathogenesis of nasal polyps. After 5 days hormone treatment, the expressions of S 100 protein and HLA-DR decreased, which suggest that hormones play some role in anti-immune action.

Key words: Glucocorticoid, Nasal polyps, S-100 protein, HLA-DR

CLC Number: 

  • R765.25
[1] Frisman D M, Taylor C R. Immunohistology of the skin: Melanoma, intermediate filament[M]// In: Taylor C R, Cote R J. Immunomicroscopy: adiagnostic tool for the surgical pathologist. 2th ed. Philadelphia: Saunders, 1994: 321.
[2] Reinherz E L, Kung P C, Pesando J M, et al. Is determinants on human T-cell subsets defined by monoclonal antibody: activation stimuli required for expression[J]. J Exp Med, 1979, 150(6):1472-1482.
[3] Coste A, Wang Q P, Roudot-Thoraval F, et al. Epithelial cell proliferation in nasal polyps could be up-regulated by platelet-derived growth factor[J]. Laryngoscope, 1996, 106(5):578-583.
[4] Li H B, Cai K M, Liu Z, et al. Foxp3+T regulatory cells(Tregs)are increased in nasal polyps(NP)after treatment with intranasal steroid[J]. Clin Immunol, 2008, 129(3):394-400.
[5] Karagiannidis C, Akdis M, Holopainen P, et al. lucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma[J]. J Allergy Clin Immunol, 2004, 114(6):1425-1433.
[1] SONG Xiaoyu, ZHANG Yu, LI Chenglin, SONG Xicheng. Enhanced recovery after surgery for the treatment of chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5): 9-12.
[2] HUANG Yuan, BA Luo, LI Bo, YU Wenxing, YANG Fangli, DU Jintao. Transcription factor NKX2-1 regulates eosinophilic inflammation in chronic rhinosinusitis with nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 17-23.
[3] CHEN Wangxing, ZHAO Xue, LIU Yan, LIU Yue, JIN Chunshun. Psychological status of patients with deviated nasal septum or chronic sinusitis with nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 24-27.
[4] Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps. Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 28-31.
[5] LI Huabin, LAI Yuting. Pathogenesis, diagnosis, and treatment of chronic rhinosinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 4-9.
[6] YU Qianqian, GUAN Ge, ZHANG Niankai, LI Na, WEN Junfeng, LIU Tingting, LIAN Yuanyuan. Characteristics of respiratory epithelial adenomatoid hamartomas in the nasal olfactory cleft on computed tomography [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 76-81.
[7] LI Hongmei, WANG Lan, GAO Zhaohui, WANG Ying, XUE Jinmei. The expression and significance of p-ERK2/ ERK2 in nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 42-46.
[8] ZHANG Jie, GONG Qi. Clinical significance of eosinophils and neutrophils in blood and allergic reaction in patients with chronic rhinosinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 54-57.
[9] GAN Bin, ZHANG Yongju, XU Anting. BRF2 in the pathogenesis of chronic rhinosinusitis with nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 47-53.
[10] GAO Jinliang, NIAN Wanqing, LI Shuo. Evaluation of the clinical curative effect of nose surgery in combination with nasal corticosteroids in [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 38-42.
[11] ZHI Lili, SONG Daoliang. Expressions of eosinophils and IL5 in antrochoanal polyps and nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 43-46.
[12] SHI Li, ZHAO Li, ZHANG Hongping. Long-term anti-inflammatory treatment of allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 9-12.
[13] LUN Jie, ZHANG Ya′nan. Analysis on the factors related to the recurrence of chronic rhinosinusitis with nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 80-83.
[14] WANG Haipeng, XU Huijuan, ZHANG Xiufang, WANG Huizhong, LI Yanzhong. The application of Sinus Jel in adult patients of nasal polyps with sleep-disordered breathing. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(5): 58-60.
[15] ZHANG Gehua, LI Wenting. Drug treatment strategy for allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 10-14.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd