Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (6): 64-67.doi: 10.6040/j.issn.1673-3770.0.2018.465

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The expression and significance of metastasis suppressor 1 protein in tongue squamous cell carcinoma

JIANG Ningning1, WANG Penglai1, YUAN Changyong1, HUANG Xiaofeng2, JIANG Changwei1, LIU Zongxiang1,SUN Tiezhong1   

  1. Department of Pathology, Affiliated Stomatological Hospital of Nanjing University, Nanjing 210008, Jiangsu, China
  • Published:2019-12-23

Abstract: Objective To compare the expression of metastasis suppressor 1(MTSS1)protein in tongue squamous cell carcinoma(TSCC)and normal tongue mucosa. Methods The expression of MTSS1 was analyzed in TSCC and normal tongue mucosa using immunohistochemical staining. Single-factor analysis was used to study the relationship between MTSS1 expression and clinicopathological factors. Results The expression of MTSS1 was lower in TSCC than in normal tongue mucosa(20 cases each). The expression of MTSS1 was higher in cases with positive lymph node metastasis(34 cases)than those negative for lymph node metastasis(46 cases). Furthermore, the expression of MTSS1 was higher in cases with higher clinical stage(37 cases)than in those with lower clinical stage(43 cases). Conclusion The decrease of MTSS1 expression may be associated with infiltration and metastasis of TSCC. MTSS1 may inhibit the occurrence and development of TSCC and play an important role in the early development of TSCC.

Key words: Metastasis suppressor 1, Tongue squamous cell carcinoma, Immunohistochemistry, Metastasis, Protein expression

CLC Number: 

  • R766.49
[1] Lee YG, Macoska JA, Korenchuk S, et al. MIM, a potential metastasis suppressor gene in bladder cancer[J]. Neoplasia, 2002, 4(4): 291-294. doi:10.1038/sj.neo.7900231.
[2] Dawson JC, Bruche S, Spence HJ, et al. Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1[J]. PLoS One, 2012, 7(3): e31141. doi:10.1371/journal.pone.0031141.
[3] Xie W, Sun F, Chen L, et al. MiR-96 promotes breast cancer metastasis by suppressing MTSS1[J]. Oncol Lett, 2018, 15(3): 3464-3471. doi:10.3892/ol.2018.7728.
[4] Xu MW, Xu T. Expression and clinical significance of miR-23a and MTSS1 in diffuse large B-cell lymphoma[J]. Oncol Lett, 2018, 16(1): 371-377. doi:10.3892/ol.2018.8657.
[5] Xu N, Yang WL, Liu Y, et al. MicroRNA-411 promoted the osteosarcoma progression by suppressing MTSS1 expression[J]. Environ Sci Pollut Res Int, 2018, 25(12): 12064-12071. doi:10.1007/s11356-018-1331-9.
[6] Schemionek M, Herrmann O, Reher MM, et al. Mtss1 is a critical epigenetically regulated tumor suppressor in CML[J]. Leukemia, 2016, 30(4): 823-832. doi:10.1038/leu.2015.329.
[7] Liu R, Martin TA, Jordan NJ, et al. Metastasis suppressor 1 expression in human ovarian cancer: The impact on cellular migration and metastasis[J]. Int J Oncol, 2015, 47(4): 1429-1439. doi:10.3892/ijo.2015.3121.
[8] Guo Y, Ren MS, Shang C, et al. MTSS1 gene regulated by miR-96 inhibits cell proliferation and metastasis in tongue squamous cellular carcinoma Tca8113 cell line[J]. Int J Clin Exp Med, 2015, 8(9): 15441-15449.
[9] Zhang SD, Qi QG. MTSS1 suppresses cell migration and invasion by targeting CTTN in glioblastoma[J]. J Neurooncol, 2015, 121(3): 425-431. doi:10.1007/s11060-014-1656-2.
[10] Zeleniak AE, Huang W, Brinkman MK, et al. Loss of MTSS1 results in increased metastatic potential in pancreatic cancer[J]. Oncotarget, 2017, 8(10): 16473-16487. doi:10.18632/oncotarget.14869.
[11] Huang XY, Huang ZL, Xu B, et al. Elevated MTSS1 expression associated with metastasis and poor prognosis of residual hepatitis B-related hepatocellular carcinoma[J]. J Exp Clin Cancer Res, 2016, 35(1): 85. doi:10.1186/s13046-016-0361-8.
[12] Zhang J, Tong Y, Ren L, et al. Expression of metastasis suppressor 1 in cervical carcinoma and the clinical significance[J]. Oncol Lett, 2014, 8(5): 2145-2149. doi:10.3892/ol.2014.2508.
[13] 张思, 李雪, 刘元林, 等. 宫颈癌中MTSS1基因与Shh信号通路的关系研究[J]. 军事医学, 2016, 40(6): 484-487. doi:10.7644/j.issn.1674-9960.2016.06.008.
[14] Peng Du, Lin Ye, Han Li. The tumour suppressive role of Metastasis Suppressor-1, MTSS1, in human kidney cancer, a possible connection with the SHH pathway[J]. J Exp Ther Oncol,2012,10(2): 91-99.
[15] Callahan CA, Ofstad T, Horng L, et al. MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription[J]. Genes Dev, 2004, 18(22): 2724-2729. doi:10.1101/gad.1221804.
[16] Kedmi M, Ben-Chetrit N, Körner C, et al. EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer[J]. Sci Signal, 2015, 8(368): ra29. doi:10.1126/scisignal.2005866.
[17] Lei R, Tang J, Zhuang X, et al. Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis[J]. Oncogene, 2014, 33(10): 1287-1296. doi:10.1038/onc.2013.65.
[18] Vadakekolathu J, Al-Juboori SIK, Johnson C, et al. MTSS1 and SCAMP1 cooperate to prevent invasion in breast cancer[J]. Cell Death Dis, 2018, 9(3): 344. doi:10.1038/s41419-018-0364-9.
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