Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (6): 6-11.doi: 10.6040/j.issn.1673-3770.0.2019.584

Previous Articles     Next Articles

Treatment of sudden seafness by heart and spleen

LIN Yushan1, LU Biaoqing2   

  1. 1. Guangzhou University of Traditional Chinese Medicine, Guangzhou 510006, Guangdong, China;
    2. Department of Otorhinolaryngology, Zhongshan Hospital of Traditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, Zhongshan 528400, Guangdong, China
  • Published:2021-01-11

Abstract: Objective The aim of this study was to examine the clinical effects of Guipi Decoction in the treatment of sudden deafness. Methods From January 2015 to June 2019, 108 patients with sudden deafness of Qi and blood deficiency type, who were hospitalized in the otolaryngology department of Zhongshan Hospital(affiliated with Guangzhou University of Traditional Chinese Medicine), and had complete clinical data were divided into the study group(n=78)and the control group(n=30). The control group was treated with conventional western medicine, while the study group was given Guipi Decoction along with western medicine treatment. Results The total effective rate of the study group was 79.49%, which was higher than that of the control group(60.00%). The difference between the two groups was statistically significant(P<0.05). There was no significant difference in the effective rate of sense(P>0.05). Conclusion The clinical effect of routine western medicine combined with Guipi Decoction in the treatment of sudden deafness of qi deficiency type is better than that of routine western medicine alone, which may have a clinical application.

Key words: Sudden deafness, Deficiency of Qi and blood, Guipi Decoction, Clinical effect

CLC Number: 

  • R764
[1] 中华耳鼻咽喉头颈外科杂志编辑委员会,中华医学会耳鼻咽喉头颈外科学分会. 突发性聋的诊断和治疗指南(2005年, 济南)[J]. 中华耳鼻咽喉头颈外科杂志, 2006, 41(5): 325. doi:10.3760/j.issn:1673-0860.2006.05.003. Editorial Board Of Chinese Journal Of Otorhinolaryngology Head And Neck Surgery, chinese Otorhinolaryngology Head And Neck Surgery Society Of Chinese Medical Association. Guideline of diagnosis and treatment of sudden deafness[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2006, 41(5): 325. doi:10.3760/j.issn:1673-0860.2006.05.003.
[2] 司亚研. 耳鸣耳聋的古代文献研究与学术源流探讨[D]. 北京: 北京中医药大学, 2017.
[3] 中医耳鼻咽喉科常见病诊疗指南[C] //世界中联耳鼻喉口腔专业委员会换届大会及第三次学术年会暨中华中医药学会耳鼻喉科分会第十七次学术交流会暨广东省中医及中西医结合学会耳鼻喉科学术交流会论文集. 广州, 2011: 835-864.
[4] 突发性聋诊断依据和疗效分级[J]. 中华耳鼻咽喉科杂志,1997(2):9.
[5] 李水静, 林运娟, 方璇, 等. 血浆纤维蛋白原水平与不同类型突发性聋的发病相关性探讨[J]. 临床耳鼻咽喉头颈外科杂志, 2019, 33(5): 425-428. doi:10.13201/j.issn.1001-1781.2019.05.010. LI Shuijing, Lin Yunjuan, Fang Xuan, et al. The correlation between plasma fibrinogen level and different types of sudden sensorineural hearing loss[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2019, 33(5): 425-428. doi:10.13201/j.issn.1001-1781.2019.05.010.
[6] Jeong J, Lim H, Lee K, et al. High risk of sudden sensorineural hearing loss in several autoimmune diseases according to a population-based national sample cohort study[J]. Audiol Neurootol, 2019, 24(5): 224-230. doi:10.1159/000502677.
[7] Shah RR, Naples JG, Ruckenstein MJ, et al. Sudden sensorineural hearing loss as a presenting symptom in superior semicircular canal dehiscence[J]. Otolaryngol Case Rep, 2019, 12: 100122. doi:10.1016/j.xocr.2019.100122.
[8] Chen X, Fu YY, Zhang TY. Role of viral infection in sudden hearing loss[J]. J Int Med Res, 2019, 47(7): 2865-2872. doi:10.1177/0300060519847860.
[9] 吴皓, 孙常领. 感音神经性耳聋的基因治疗研究进展[J]. 中国听力语言康复科学杂志, 2017, 15(3): 201-204. doi:10.3969/j.issn.1672-4933.2017.03.012. WU Hao, SUN Changling. Developments in gene therapy for sensorineural hearing loss[J]. Chinese Scientific Journal of Hearing and Speech Rehabilitation, 2017, 15(3): 201-204. doi:10.3969/j.issn.1672-4933.2017.03.012.
[10] 徐丽娜, 高艳慧, 何双八. 南京地区耳聋患者常见耳聋基因突变的分析[J]. 山东大学耳鼻喉眼学报, 2019, 33(6): 45-48. doi: 10.6040/j.issn.1673-3770.0.2019.184. XU Lina, GAO Yanhui, HE Shuangba. Analysis of common deafness gene mutations in patients with deafness in Nanjing[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(6): 45-48. doi: 10.6040/j.issn.1673-3770.0.2019.184.
[11] 钱怡. 突发性耳聋治疗及预后临床研究、SIK3基因多态性与突发性聋遗传易感性研究[D]. 重庆: 重庆医科大学, 2019.
[12] 崔珑, 辛文君, 党攀红, 等. LDLR基因多态性与突发性耳聋易感性的关联性分析[J]. 中国耳鼻咽喉颅底外科杂志, 2018, 24(1): 7-12, 16. doi:10.11798/j.issn.1007-1520.201801002. CUI Long, XIN Wenjun, DANG Panhong, et al. Correlation analysis of LDLR gene polymorphisms and susceptibility of sudden sensorineural hearing loss[J]. Chinese Journal of Otorhinolaryngology-Skull Base Surgery, 2018, 24(1): 7-12, 16. doi:10.11798/j.issn.1007-1520.201801002.
[13] 张俊军, 刘海莉, 刘加福, 等. 糖皮质激素不同给药方式治疗突发性聋的临床疗效及安全性研究[J]. 山东大学耳鼻喉眼学报, 2019, 33(4): 52-55. doi:10.6040/j.issn.1673-3770.0.2018.408. ZHANG Junjun, LIU Haili, LIU Jiafu, et al. Clinical efficacy and safety of different methods of administration of glucocorticoids in the treatment of sudden deafness[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 52-55. doi:10.6040/j.issn.1673-3770.0.2018.408.
[14] Amarillo E, Hernando M, Eisenberg G, et al. Efficacy of intratympanic corticosteroid as a salvage treatment in idiopathic sudden sensorineural hearing loss[J]. Acta Otorrinolaringol Esp, 2019, 70(4): 207-214. doi:10.1016/j.otorri.2018.04.009.
[15] 韦小丽. 单纯使用金纳多治疗突发性耳聋的临床观察[J]. 北方药学, 2018, 15(7): 59. Doi: CNKI:SUN:BFYX.0.2018-07-045.
[16] 陈尔东. 甲钴胺联合马来酸桂哌齐特治疗老年性耳聋的临床疗效分析[J]. 中国医刊, 2019, 54(12): 1335-1339. doi:10.3969/j.issn.1008-1070.2019.12.019. CHEN Erdong. Mechanism and safety of mecobalamin combined with cinepazide in the treatment of presbycusis[J]. Chinese Journal of Medicine, 2019, 54(12): 1335-1339. doi:10.3969/j.issn.1008-1070.2019.12.019.
[17] 张旻, 韩学锋, 韩淼淼, 等. 巴曲酶在全聋型突发性聋患者常规治疗无效后的疗效观察[J]. 中华耳科学杂志, 2019, 17(2): 218-221. doi: 103969/j.issn.1672-2922.2019.02.015. ZHANG Min, HAN Xuefeng, HAN Miaomiao, et al. Effects of batroxobin in patients with total sudden deafness unresponsive to routine therapies[J]. Chinese Journal of Otology, 2019, 17(2): 218-221. doi: 103969/j.issn.1672-2922.2019.02.015.
[18] 叶谋华. 前列地尔和舒血宁治疗突聋的疗效对比及血液流变学的改变[J]. 现代诊断与治疗, 2016, 27(24): 4680-4681. doi:10.3969/j.issn.1001-8174.2016.24.058.
[19] 田晓玲, 任金平, 孙西峰, 等. 通窍活血汤加减治疗气滞血瘀型突发性耳聋的临床研究[J]. 世界最新医学信息文摘, 2019, 19(66): 12-13. doi:10.19613/j.cnki.1671-3141.2019.66.006. TIAN Xiaoling, REN Jinping, SUN Xifeng, et al. Clinical study on treatment of sudden deafness caused by qi and blood stasis by Tongqiao Huoxue decoction[J]. World Latest Medicine Information, 2019, 19(66): 12-13. doi:10.19613/j.cnki.1671-3141.2019.66.006.
[20] 王庆亮, 徐锦, 戈言平, 等. 五苓散在突发性耳聋中的疗效观察[J]. 中国现代医生, 2019, 57(19): 84-87. WANG Qingliang, XU Jin, GE Yanping, et al. Therapeutic effect of Wulingsan in sudden deafness[J]. China Modern Doctor, 2019, 57(19): 84-87.
[21] 陈伟, 胡中南, 童钊君, 等. 通窍活血汤对青中年突发性耳聋患者的疗效及血液流变学变化分析[J]. 中医药信息, 2019, 36(1): 45-48. doi:10.19656/j.cnki.1002-2406.190011. CHEN Wei, HU Zhongnan, TONG Zhaojun, et al. Tongqiao Huoxue decoction combined with mouse nerve growth factor treating sudden deafness of young adults: a study on clinical efficacy and influence to hemorheology[J]. Information on Traditional Chinese Medicine, 2019, 36(1): 45-48. doi:10.19656/j.cnki.1002-2406.190011.
[22] 陈静. 针灸治疗气滞血瘀型突发性耳聋的临床疗效观察[J]. 内蒙古中医药, 2019, 38(5): 95-96. doi:10.16040/j.cnki.cn15-1101.2019.05.066.
[23] 黄晓芳. 耳穴压豆应用于突发性耳聋的疗效观察[J]. 实用中西医结合临床, 2015, 15(7): 60, 66. doi:10.13638/j.issn.1671-4040.2015.07.036.
[24] 阳俊杰. 穴位注射治疗突发性耳聋疗效观察[J]. 实用中医药杂志, 2016, 32(2): 143-143, 144. doi:10.3969/j.issn.1004-2814.2016.02.036.
[25] 李种泰. 颈椎推拿加电针联合治疗38例突发性耳聋临床观察[J]. 延边大学医学学报, 2014, 37(3): 204-207. doi:10.16068/j.1000-1824.2014.03.017. LI Zhongtai. Clinical observation on 38 cases of sudden hearing loss with combined treatment of massage and electroacupuncture[J]. Journal of Medical Science Yanbian University, 2014, 37(3): 204-207. doi:10.16068/j.1000-1824.2014.03.017.
[26] 罗伟君, 陈楚丽. 针灸联合龙胆泻肝汤治疗突发性耳聋临床研究[J]. 湖北中医杂志, 2019, 41(1): 35-37.
[27] 王翔, 谭业农, 谢柳, 等. 补中益气汤联合耳后注射治疗突发性耳聋的临床效果[J]. 中国医药导报, 2019, 16(9): 137-140. doi: CNKI:SUN:YYCY.0.2019-09-036. WANG Xiang, TAN Yenong, XIE Liu, et al. Clinical effect of Buzhong Yiqi Decoction combined with post-auricular injection for sudden hearing loss[J]. China Medical Herald, 2019, 16(9): 137-140. Doi: CNKI:SUN:YYCY.0.2019-09-036.
[28] 王勇. 丹参川芎嗪注射液联合针灸治疗突发性耳聋的有效性及安全性分析[J]. 中国实用医药, 2018, 13(29): 103-105. doi:10.14163/j.cnki.11-5547/r.2018.29.057. WANG Yong. Effectiveness and safety analysis of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with acupuncture in the treatment of sudden deafness[J]. China Practical Medicine, 2018, 13(29): 103-105. doi:10.14163/j.cnki.11-5547/r.2018.29.057.
[29] 柴龙, 张满. 针灸结合穴位注射治疗突发性耳聋30例[J]. 云南中医中药杂志, 2018, 39(8): 54-55. doi:10.16254/j.cnki.53-1120/r.2018.08.023.
[30] 赵彦秋. 针药并用治疗气滞血瘀型突发性耳聋疗效评价[J]. 临床研究, 2019(2): 110-111. doi: 10.3969/j.issn.1004-8650.2019.02.062.
[1] SHI Anni, ZHANG Jiajia, BAI Peng, ZHANG Chongyang. Analysis of a therapeutic modality for sudden deafness utilizing neck acupuncture comprising seven lines of treatment [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 103-107.
[2] ZHANG Min, LIU Yongliang, SONG Daoliang, HAN Xuefeng, FENG Xinrong, ZHAO Yunpei. A comparative study on the treatment of severe chronic hypertrophic rhinitis by modified inferior turbinate plasty under nasal endoscopy and low-temperature plasma ablation with fracture displacement of the inferior turbinate [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 83-88.
[3] LI Wei, ZHANG Bin. Effects of optimal pulse technology combined with meibomian gland massage to treat meibomian gland dysfunction [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(2): 105-109.
[4] Yiliang YE,Biaoqing LU. Therapeutic outcome analysis of 704 cases of sudden deafness [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 44-47.
[5] Xiaosheng ZHONG,Haidi YANG,Yiqing ZHENG. Treatment and outcome of tinnitus in sudden deafness [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 43-46.
[6] ZHAO Junying, WANG Jianming. Correlation between unilateral sudden deafness and imaging features of vertebrobasilar artery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 47-51.
[7] ZHANG Junjun, LIU Haili, LIU Jiafu, QIN Xiaofeng, DU Hongming, WANG Houhui. Clinical efficacy and safety of different methods of administration of glucocorticoids in the treatment of sudden deafness [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 52-55.
[8] TONG Qiaozhen, ZHAO Yan, CHENG Sihua. The constructive and mediating effects of knowledge/attitude/belief/practice interference on negative emotion in patients with sudden deafness [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 162-164.
[9] CHEN Wei, HU Zhongnan, TONG Zhaojun, LI Xiangyu, LIU Wenjun. Characteristics of auditory brainstem response to high-frequency stimulus in young and middle-aged patients with sudden deafness and no history of vertigo or cardiocerebrovascular disease [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 45-49.
[10] MENG Lixin, LI Jian, WEI Shanwen. Insertion of microtubules in tympanic membrane for the treatment of middle ear atelectasis [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 61-65.
[11] WU Xiangping. Influence of patient management on the clinical effect of sublingual dermatophagoides farinae drops in patients [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 68-72.
[12] GAO Jinliang, NIAN Wanqing, LI Shuo. Evaluation of the clinical curative effect of nose surgery in combination with nasal corticosteroids in [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(2): 38-42.
[13] ZHANG Yubo, YUE Liyan, YIN Xiaoyan, LÜ Zhe, SHAN Chunguang. Effect of tinnitus treatment instrument combined with Ginkgo biloba extract on hearing and hemorheology in patients with sudden deafness and tinnitus. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 50-53.
[14] ZHOU Xueyi, LI Yiming, WANG Meiju, ZHANG Yuanyuan, ZHANG Lizhuo. Clinical observation of 25-gauge minimally invasive vitreous retinal surgery for treatment of rhegmatogenous retinal detachment. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(5): 92-94.
[15] ZHU Jiangbin, NAN Bingwei, CHEN Tao, HAO Zongsheng. Treatment of residual tinnitus after threshold recovery of low frequency sudden deafness: a report of 129 cases. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 5-7.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(2): 116 -118 .
[2] ZHOU Zi-ning,JIN Guo-wei . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(5): 462 -465 .
[3] ZHOU Bin,LI Bin . Endoscopic sinus surgery for 75 patients with chronic sinusitis and nasal polyps[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 24 -26 .
[4] XU Sainan,YANG Lei . Apoptosis of epithelial cells in nasal polyps promoted by erythromycin[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 27 -29 .
[5] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 94 -95 .
[6] LIU Lian-he . Treatment of deep neck abscess in 37 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(2): 180 -181 .
[7] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 200 -203 .
[8] QIAO Yi,NI Guan-sen,CHEN Wen-wen . Effect of H-UPPP and nasal operations on obstructive sleep apnea syndrome in 38 cases
[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 206 -208 .
[9] WANG Xiao-feng,LIN Chang,CHENG Jin-mei . Expression of ABAD in inner ears and its clinical significance in different age mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 207 -211 .
[10] FAN Qi-jun,HUANG Zhi-wu,MEI Ling,XIAO Bo-kui . Expression of the heat shock protein 27 in rat cochlea induced by sodium salicylate injection by the FQ-PCR technique[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 212 -214 .