Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (4): 45-50.doi: 10.6040/j.issn.1673-3770.0.2020.481

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Five cases of metastatic clear cell carcinoma of the head and neck: a case report and literature review

LIU Pan1,2, WANG Chuan1,2, ZHAO Zeqi1,2, WU Mei1,3, XU Jifeng1,2, LI Wei2, ZHANG Weiqiang2, LIU Wen2   

  1. 1. Graduate School of Xuzhou Medical University, Xuzhou 221004, Jiangsu, China;
    2. Department of Otolaryngology & Head and Neck Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu, China;
    3. Department of Pathology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu, China
  • Published:2021-08-05

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Abstract: Objective To explore the location and treatment of the metastasis of clear cell carcinoma of the urinary system to the head and neck. Methods Five cases of metastatic clear cell carcinoma of the head and neck admitted to our hospital during 2011-2018 were summarized. The clinical data and treatment method of the primary disease, time of metastasis, site of metastasis, treatment approach for the metastasis, and prognosis were recorded. Results Five cases of clear cell carcinoma involved primary lesions in the kidney(4 cases)and bladder(1 case), all of which underwent radical surgery. The metastases developed 1-10 years after the surgery of the primary lesions, including 1 case involving the maxillary sinus, 1 case involving the frontal sinus and bone, 1 case involving the frontal and ethmoid sinus, 1 case involving the ventricular band, and 1 case involving the frontal subcutaneous area. All four patients had recurrence and died of systemic metastasis, and only 1 patient with subcutaneous metastasis survived. Conclusion Metastasis of clear cell carcinoma to the head and neck is rare. Radical surgical resection is the main method for treating metastatic clear cell carcinoma of the head and neck. Most patients die due to multiple metastases throughout the body.

Key words: Head and neck, Clear cell carcinoma, Metastasis, Treatment, Prognosis

CLC Number: 

  • R739.62
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