Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (4): 35-39.doi: 10.6040/j.issn.1673-3770.0.2021.140

Previous Articles     Next Articles

Laryngeal involvement in progressive nodular histiocytosis: a case report with literature review

LIAO Jingwen1, CHEN Min1, LI Na1, HUANG Yichuan1, ZHAO Han2   

  1. Affiliated Hospital of Qingdao University 1.Department of Otorhinolaryngology & Head and Neck Surgery;
    2. Department of Pathology Qingdao 266071, Shandong, China;
  • Published:2021-08-05

PDF (PC)

131

Abstract: Objective To explore the diagnosis and treatment, the clinical characteristic, as well as the pathological features, of a rare case of progressive nodular histiocytosis involving the larynx. Methods Patient case data, pathological sections were extracted and observed by immunohistochemical staining to summarize the characteristics of this case and to consult the literature related to PNH. Results The pathology of the patient in this case suggested a diffuse infiltration of spindle cells, and immunohistochemistry was positive for CD68 and CD163. The patient presented with supraglottic stenosis, thickening of the tracheal wall, and multiple nodules in the trachea. The patient had undergone a tracheotomy due to dyspnea. This disease involves the skin, and it manifests in multiple nodules and facial nodules that give rise to a “lion face” appearance. After diagnosis, treatment with anlotinib can delay the development of this disease. Conclusion The disease is diagnosed based on pathological examination. It can involve the larynx and cause breathing difficulties. Surgical removal of the facial nodules is not recommended unless body function is seriously affected.

Key words: Histiocytosis, Non-neoplastic proliferative skin disease, Non-Langerhans cell histiocytosis, Laryngeal

CLC Number: 

  • R758.6
[1] Taunton OD, Yeshurun D, Jarratt M. Progressive nodular histiocytoma[J]. Arch Dermatol, 1978, 114(10): 1505-1508.
[2] 渠涛, 方凯. 进行性结节性组织细胞增生症[J]. 临床皮肤科杂志, 2015,44(9): 555-558. doi:10.16761/j.cnki.1000-4963.2015.09.022. QU Tao, FANG Kai. Progressive nodular Histiocytosis: a case report and literature review[J]. J Clin Dermatol, 2015,44(9): 555-558. doi:10.16761/j.cnki.1000-4963.2015.09.022.
[3] Chu AC. The confusing state of the histiocytoses[J]. Br J Dermatol, 2000, 143(3): 475-476. doi:10.1111/j.1365-2133.2000.03821.x.
[4] Glavin FL, Chhatwall H, Karimi K. Progressive nodular Histiocytosis: a case report with literature review, and discussion of differential diagnosis and classification[J]. J Cutan Pathol, 2009, 36(12): 1286-1292. doi:10.1111/j.1600-0560.2009.01454.x.
[5] Amin SM, Riddle C, Fraga GR, et al. Progressive nodular Histiocytosis with normal karyotypic analysis[J]. Dermatol Online J, 2013, 19(6): 18577.
[6] Nofal A, Assaf M, Tawfik A, et al. Progressive nodular Histiocytosis: a case report and literature review[J]. Int J Dermatol, 2011, 50(12): 1546-1551. doi:10.1111/j.1365-4632.2011.04904.x.
[7] Hilker O, Kovneristy A, Varga R, et al. Progressive nodular Histiocytosis[J]. J Ger Soc Dermatol: JDDG, 2013, 11(4): 301-307. doi:10.1111/j.1610-0387.2012.08069.x.
[8] Bratschi MW, Steinmann P, Wickenden A, et al. Current knowledge on Mycobacterium leprae transmission: a systematic literature review[J]. Lepr Rev, 2015, 86(2): 142-155.
[9] 程海星, 葛兰, 翟志芳, 等. 肉芽肿性蕈样肉芽肿[J]. 临床皮肤科杂志, 2019,48(12): 749-751. doi:10.16761/j.cnki.1000-4963.2019.12.013. CHENG Haixing, GE Lan, ZHAI Zhifang, et al. A case of granulomatous mycosis fungoides[J]. J Clin Dermatol, 2019,48(12): 749-751. doi:10.16761/j.cnki.1000-4963.2019.12.013.
[10] Spagnolo P, Renzoni EA, Wells AU, et al. C-C chemokine receptor 2 and sarcoidosis: association with Lofgren's syndrome[J]. Am J Respir Crit Care Med, 2003, 168(10): 1162-1166. doi:10.1164/rccm.200303-456OC.
[11] 王晓琴, 程岩峰, 韩秀萍. 皮肤结节病12例诊断与误诊分析[J]. 中国误诊学杂志, 2011, 11(3): 638.
[12] Gonzalez Ruíz A, Bernal Ruíz AI, Aragoneses Fraile H, et al. Progressive nodular Histiocytosis accompanied by systemic disorders[J]. Br J Dermatol, 2000, 143(3): 628-631. doi:10.1111/j.1365-2133.2000.03723.x.
[13] Watanabe T, Watanabe D, Tamada Y, et al. Progressive nodular Histiocytosis-A five-year follow up[J]. Eur J Dermatol, 2008, 18(2): 200-202. doi:10.1684/ejd.2008.0370.
[14] Huet F, Brenaut E, Costa S, et al. Progressive nodular Histiocytosis improved by methotrexate[J]. Eur J Dermatol, 2017, 27(6): 661-663. doi:10.1684/ejd.2017.3115.
[15] Williams A, Thomas AG, Kwatra KS, et al. Progressive nodular Histiocytosis associated with eale's disease[J]. Indian J Dermatol, 2015, 60(4): 388-390. doi:10.4103/0019-5154.160492.
[16] 王俊, 冉凤鸣, 金兵. 安罗替尼治疗恶性肿瘤的临床研究进展[J]. 中国肿瘤, 2019, 28(5): 359-366. doi:10.11735/j.issn.1004-0242.2019.05.A008. WANG Jun, RAN Fengming, JIN Bing. Progress on clinical research of anlotinib in cancer treatment[J]. China Cancer, 2019, 28(5): 359-366. doi:10.11735/j.issn.1004-0242.2019.05.A008.
[17] Wang LL, He Z, Yang S, et al. The impact of previous therapy strategy on the efficiency of anlotinib hydrochloride as a third-line treatment on patients with advanced non-small cell lung cancer(NSCLC): a subgroup analysis of ALTER0303 trial[J]. Transl Lung Cancer Res, 2019, 8(5): 575-583. doi:10.21037/tlcr.2019.09.21.
[18] Chi Y, Fang ZW, Hong XN, et al. Safety and efficacy of anlotinib, a multikinase angiogenesis inhibitor, in patients with refractory metastatic soft-tissue sarcoma[J]. Clin Cancer Res, 2018, 24(21): 5233-5238. doi:10.1158/1078-0432.CCR-17-3766.
[1] MAO ZefanOverview,CHEN Xi, CHENG LeiGuidance. Research advances in neuroendocrine carcinoma of the larynx [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 114-119.
[2] WANG MeiOverview,LI ZhihaiGuidance. Laryngeal cancer stem cells: potential therapeutic targets for overcoming multidrug resistance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 120-128.
[3] WANG Xiaoting, CHEN Zhengnong, YI Hongliang. Transcriptomic analysis of glutamine deprivation on laryngeal carcinoma cells [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 26-31.
[4] LIU Yong, YUAN Cunli, CAO Hui, ZHENG Chengcai, CHAO Fang, XU Fenglei. CHD1L promotes proliferation, invasion and metastasis of laryngeal squamous cell carcinoma cells by EMT [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 32-39.
[5] ZENG Bin, LÜ Dan, REN Jia, HU Juanjuan, YU Lingyu, LU Huan, YANG Hui. Application of laryngeal microsurgery in severe neonatal upper airway obstruction [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 95-99.
[6] HUANG Guiliang, SUN Changzhi, LUO Renzhong, CHEN Yanqiu, LIU Shaofeng, XU Jiajian. Clinical application analysis of endoscope in the operation of infantile tongue base cyst [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 100-105.
[7] LI Yanjie, JIA Jian, YANG Ping, WAN Baoluo. Study on the value of tumor abnormal protein in clinical diagnosis of laryngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(5): 70-74.
[8] QI Wenwen, CHEN Luqiu, JIA Tao, CHEN Xuemei, ZHANG Jie, ZHANG Hao, JIN Peng, ZHANG Hu. Potential biomarkers and bioinformatics analysis of differentially expressed genes in recurrent laryngeal papilloma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(5): 75-84.
[9] WU Yungang, ZHANG Hui, SUN Juxing, LIU Tao, WANG Caihua, YANG Xinxin, MA Linxiang, LI Xiaoying, PANG Taizhong, LI Xiaoyu. Excision of T1B glottic carcinoma using the combined approach of cricothyroid membrane and laryngeal ventricle [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(4): 30-34.
[10] NIU Zijie, XIAO Yang,WANG Jun,MA Lijinng. Progress in the surgical treatment of recurrent laryngeal papillomatosis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(4): 96-100.
[11] SHI Yuqi, SHE Cuiping, ZHANG Qingfeng, LIU Delong, JIAO Mengsi. Experience and lessons of diagnosis and treatment of laryngeal infection after low temperature plasma radiofrequency surgery for early glottic carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(4): 129-134.
[12] YAN Jing, REN Xiaoyong, XIANG Li, DU Xiaoying, LI Na, LIU Xiaohong, HOU Jin. Preliminary observation of the immediate curative effect of unilateral idiopathic vocal cord palsy after electrical stimulation of the nerve [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 42-46.
[13] SUN Hao,ZHANG Jie, YANG Yang, NI Shuren, WU Yuhua, LIU Yuanhu, NI Xin. Application of hysteroscopy during surgery for difficult glottis exposure in patients with laryngeal lesions [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 92-95.
[14] ZHOU En, XIAO Yu, XIAO Xuping. Application progress of radiofrequency ablation technology in the treatment of early glottic carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(2): 9-15.
[15] LI Wenjing, LIU Ming. Research progress on the relationship between the C2H2 zinc finger protein family and laryngeal cancer [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 125-130.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] YANG Changliang,HUANG Zhiwu,YAO Hangqi,ZHU Yong,SNU Yi . Study on auditory brainstem response[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 9 -13 .
[2] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 89 -89 .
[3] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 90 -91 .
[4] LIU Da-yu,PAN Xin-liang,LEI Da-peng,ZHANG Li-qiang,LUAN Xin-yong . Surgical treatment for medial wall pyriform sinus cancer[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(1): 8 -11 .
[5] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(2): 188 -188 .
[6] LIU Yan,LIU Xin-yi,WANG Jin-ping,LI Da-jian . Measurement of the posterior tympanum and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 218 -221 .
[7] ZHAO Min,WANG Shou-sen,ZHEN Ze-nian,CHEN Xian-ming,WANG Mao-xin . Sphenoid sinus and trans-sphenoid surgery under nasal endoscopy and microscopy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 244 -245 .
[8] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 252 -252 .
[9] WANG Hong-xia,WANG Peng-cheng . Expression of NSE,S100 and GFAP in retinoblastoma and its clinical significance[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 263 -264 .
[10] HUANG Fang,HUANG Hai-qiong,HUANG Jian-qiang,HE He-fan . Bronchoscopic video supervision system in infant bronchial foreign bodies[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 276 -277 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd