Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (3): 125-142.doi: 10.6040/j.issn.1673-3770.0.2022.052

• 综述 • Previous Articles    

Diagnosis and treatment of exudative age-related macular degeneration combined with retinal pigment epithelial detachment

XU Enpei1, SUN Xianyong2   

  1. 1. School of Clinical Medicine, Weifang Medical University, Weifang 261053, Shandong, China;
    2. Fundus disease area, Weifang Eye Hospital, Weifang 261041, Shandong, China
  • Published:2023-05-24

Abstract: Retinal pigment epithelial detachment(PED)is the separation of the collagen layer in the retinal pigment epithelial(RPE)layer of the base film from the glass membrane(Bruch's membrane), which can be divided into many forms depending on the properties of the fluid substrate of the RPE layer. Among these forms, serous pigment epithelium detachment(sPED)is most commonly used for slurry-liquid retinal pigment epithelial disengagement. Exudative age-related macular degeneration(eAMD)is the most common form of disease in PED. Clinically, the specific pathogenesis of PED is still unclear. The current clinical and widely recognized PED pathogenesis is that the Bruch's membrane and vein membrane permeation coefficient decreases, resulting the reduction of fluid exchange in the RPE layer and vein membrane. This can lead to liquid accumulation under the RPE layer, thus resulting in the separation of the RPE layer. At present, the treatment of PED in clinical practice mainly includes under-eye retina laser photocoagulation, anti-neovascular drug vitreous body injection therapy, and photodynamic therapy. Based on the latest progress of research locally and internationally, this paper summarizes the epidemiology, pathogenesis, diagnosis, and treatment of eAMD with PED, and discusses and prospects of its treatment methods.

Key words: Exudative age-related macular degeneration, Retinal pigment epithelial detachment, Polypoid choroidal vascular lesions, Retinal angiomatous proliferation, Vascular endothelial growth factor

CLC Number: 

  • R774.5
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