Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (5): 68-73.doi: 10.6040/j.issn.1673-3770.0.2022.469

• Original Article • Previous Articles     Next Articles

Kujiu decoction for refractory pharyngeal ulceration: a case report and literature review

YAO Yuning1, ZHANG Longsheng1, SUN Jing2, CAO Kegang3   

  1. 1. Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100700, China2. Tongzhou District, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing 101121, China3. Beijing University of Traditional Chinese Medicine Brain Disease Research Institute, Beijing 100027, China
  • Published:2023-10-13

PDF (PC)

37

Abstract: Objective To report a case of refractory pharyngeal ulceration treated with Kujiu decoction according to the ancient Chinese literature, Shanghanlun, and study the specific syndrome and formulation of Kujiu decoction. Methods This study reviewed and summarized the diagnosis and treatment process of a case of refractory pharyngeal ulceration that was treated with Kujiu decoction. Findings from a review of the literature on the prescription, formulation, and indications of Kujiu decoction were summarized. Results Kujiu decoction was effective for pharyngalgia, pharyngeal ulcerations, and aphonia caused by “Shaoyin disease” and “Yin deficiency and fire exuberance syndromes”. Vinegar can be used as Kujiu. In Kujiu decoction, Kujiu, pinellia, and albumen were used together to achieve the effects of nourishing yin, clearing heat, and resolving phlegm, which in turn, treated pharyngalgia and pharyngeal ulceration. Zhang Zhongjing's method of adding albumen after the temperature of the decoction became lukewarm may enhance the effects. Clinically, Kujiu decoction can be used to treat acute and chronic pharyngitis, aphonia, laryngogenic cough, globus hysteriocus, and oral ulcerations after radiotherapy. Conclusion Kujiu decoction has definite clinical efficacy in the treatment of pharyngeal ulcerations and other pharyngeal diseases. Further studies on the optimal decoction formulation are warranted. Furthermore, in the future, studies that investigate its clinical applications and mechanisms of action are also necessary.

Key words: Shang han lun(Treatise on febrile diseases), Kujiu decoction, Pharyngeal ulcer, Decoction

CLC Number: 

  • R276.1
[1] 刘锦, 王江娇, 刘静. 刘静从阳虚论治难治性咽部溃疡经验[J]. 辽宁中医杂志, 2019, 46(6): 1158-1160. doi:10.13192/j.issn.1000-1719.2019.06.011 LIU Jin, WANG Jiangjiao, LIU Jing. Liujing's experience in treating refractory pharyngeal ulcer from Yang deficiency[J]. Liaoning Journal of Traditional Chinese Medicine, 2019, 46(6): 1158-1160. doi:10.13192/j.issn.1000-1719.2019.06.011
[2] 艾思南, 王耀献, 王珍, 等. 《伤寒论》中“阴阳自和”概念浅析[J]. 北京中医药, 2021, 40(4): 399-401. doi:10.16025/j.1674-1307.2021.04.018 AI Sinan, WANG Yaoxian, WANG Zhen, et al. Analysis of “Yin and Yang self-harmony” in treatise on febrile diseases[J]. Beijing Journal of Traditional Chinese Medicine, 2021, 40(4): 399-401. doi:10.16025/j.1674-1307.2021.04.018
[3] 柯琴. 伤寒附翼[M].李顺保,程卫东校注. 北京: 学苑出版社, 2013
[4] 李中梓.李中梓医学全书·伤寒括要[M].2版,北京:中国中医药出版社,2016
[5] 钱潢. 伤寒溯源集[M].谢忠礼,陈素美校注. 北京: 中国中医药出版社, 2015
[6] 王叔和. 注解伤寒论[M].北京: 人民卫生出版社, 2012
[7] 刘渡舟. 刘渡舟伤寒论讲稿[M]. 王庆国,李宇航,陈萌 整理.北京: 人民卫生出版社, 2008
[8] 胡希恕. 伤寒论通俗讲话[M].冯世纶整理. 北京: 中国中医药出版社, 2008: 90
[9] 黄元御. 长沙药解[M].伍悦点校. 北京: 学苑出版社, 2011
[10] 危亦林. 世医得效方[M].戴铭校注. 2版. 北京: 中国中医药出版社, 2009
[11] 闫敏敏, 李天昊, 杨舒佳, 等. 医用“苦酒”文献源流考辨[J]. 中华中医药杂志, 2021, 36(7): 3900-3903 YAN Minmin, LI Tianhao, YANG Shujia, et al. Textual research on the origin and development of medical’Kujiu’ literature[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2021, 36(7): 3900-3903
[12] 卢之颐. 本草乘雅半偈[M].张永鹏校注. 北京: 中国医药科技出版社, 2014
[13] 陈亦人. 《伤寒论》求是(修订版)[M]. 上海: 上海科学技术出版社, 2012
[14] 巩颖, 顾媛媛, 刘文亚, 等. 基于临床中药学思维的半夏泻心汤临床用药探析[J]. 北京中医药, 2018, 37(10): 996-998. doi:10.16025/j.1674-1307.2018.10.024 GONG Ying, GU Yuanyuan, LIU Wenya, et al. Analysis of clinical medication of Banxia Xiexin Decoction based on clinical thinking of traditional Chinese medicine[J]. Beijing Journal of Traditional Chinese Medicine, 2018, 37(10): 996-998. doi:10.16025/j.1674-1307.2018.10.024
[15] 贺华, 刘闯, 王保华, 等. 论《伤寒杂病论》中半夏当为鲜半夏[J]. 亚太传统医药, 2019, 15(12): 63-65. doi:10.11954/ytctyy.201912021 HE Hua, LIU Chuang, WANG Baohua, et al. Pinelliae rhizome in treatise on cold pathogenic and miscellaneous diseases should be fresh pinelliae rhizoma[J]. Asia-Pacific Traditional Medicine, 2019, 15(12): 63-65. doi:10.11954/ytctyy.201912021
[16] 刘敏, 郭明章, 李宇航, 等. 仲景方中半夏用药剂量及配伍比例研究[J]. 北京中医药大学学报, 2010, 33(6): 365-368 LIU Min, GUO Mingzhang, LI Yuhang, et al. Dosage and combination proportion of Banxia(Rhizome Pinelliae)in ZHANG Zhongjing's formulas[J]. Journal of Beijing University of Traditional Chinese Medicine, 2010, 33(6): 365-368
[17] 左季云. 伤寒论类方汇参: 李可批注版[M]. 北京: 中国医药科技出版社, 2017
[18] 张锦, 王克穷. 苦酒汤治疗放疗后口腔溃疡体会[J]. 实用中医药杂志, 2015, 31(9): 866 ZHANG Jin, WANG Keqiong. Experience of kujiu decoction in treating oral ulcer after radiotherapy[J]. Journal of Practical Traditional Chinese Medicine, 2015, 31(9): 866
[19] 谈博, 操红缨. 少阴病咽痛之方证考释[J]. 中华中医药学刊, 2007, 25(2): 372-373. doi:10.13193/j.archtcm.2007.02.181.tanb.082 TAN Bo, CAO Hongying. Textual research on prescription and syndrome of sore Yin disease and pharyngalgia[J]. Chinese Archives of Traditional Chinese Medicine, 2007, 25(2): 372-373. doi:10.13193/j.archtcm.2007.02.181.tanb.082
[20] 林慧光. 陈修园医学全书: 明清名医全书大成[M]. 北京: 中国中医药出版社, 1999
[21] 李泽明, 程绍民. 浅析仲景论治少阴咽痛诸证[J]. 浙江中医杂志, 2020, 55(2): 149-150. doi:10.13633/j.cnki.zjtcm.2020.02.045 LI Zeming, CHENG Shaomin. Analysis of Shao-Yin pharyngalgia evidence of zhongjing treatment[J]. Zhejiang Journal of Traditional Chinese Medicine, 2020, 55(2): 149-150. doi:10.13633/j.cnki.zjtcm.2020.02.045
[22] 张众,田乐,赵莹,等.苦酒汤配方工艺优化及其药效机制研究[J/OL].中国现代应用药学:1-6[2023-02-20].http://kns.cnki.net/kcms/detail/33.1210.R.20220915.1639.002.html
[23] 写国斌, 曾志秀. 加味苦酒汤治疗急性扁桃体炎80例疗效观察[J]. 中医临床研究, 2014, 6(17): 115-116. doi:10.3969/j.issn.1674-7860.2014.17.067 XIE Guobin, ZENG Zhixiu. Clinical observation on treating 80 cases of acute tonsillitis with Kujiu Decoction[J]. Clinical Journal of Chinese Medicine, 2014, 6(17): 115-116. doi:10.3969/j.issn.1674-7860.2014.17.067
[24] 李月. 改良苦酒汤促进慢性扁桃体炎术后恢复的临床疗效观察[D]. 南京: 南京中医药大学, 2020
[25] 王淑珍, 钟彦. 苦酒汤改良剂型治疗急性咽喉病53例[J]. 河南中医, 1998, 18(5): 63-64 WANG Shuzhen, ZHONG Yan. Treatment of 53 cases of acute throat disease with modified formulation of kujiu decoction[J]. Henan Traditional Chinese Medicine, 1998, 18(5): 63-64
[26] 徐建英. 苦酒汤治疗慢性咽炎358例[J]. 甘肃中医, 1995, 8(6): 14 XU Jianying. Treatment of 358 cases of chronic pharyngitis with kujiu decoction[J]. Gansu Journal of Traditional Chinese Medicine, 1995, 8(6): 14
[27] 刘玉平, 宋凤丽, 康宁, 等. 苦酒汤治疗急性放射性食管炎初探[J]. 中华中医药杂志, 2022, 37(6): 3200-3203 LIU Yuping, SONG Fengli, KANG Ning, et al. Preliminary study on Kujiu Decoction in treating acute radiation esophagitis[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2022, 37(6): 3200-3203
[28] 郑文少, 许先鑫, 郑亿彬, 等. 改良苦酒汤治疗喉源性咳嗽的临床研究[J]. 中国医药科学, 2011, 1(15): 118-118, 120 ZHENG Wenshao, XU Xianxin, ZHENG Yibin, et al. Report of the clinical effects by using improved Kujiu Decoction to cure against laryngeal cough[J]. China Medicine and Pharmacy, 2011, 1(15): 118-118, 120
[29] 朱安龙. 蒺麦饮合苦酒汤治疗梅核气70例[J]. 实用中医药杂志, 2001, 17(12): 7. doi:10.3969/j.issn.1004-2814.2001.12.005 ZHU Anlong. Globus hystericus(70 cases)treated by ji-Mei decotion and ku-Jiu decoction[J]. Journal of Practical Traditional Chinese Medicine, 2001, 17(12): 7. doi:10.3969/j.issn.1004-2814.2001.12.005
[30] 邵桂珍, 王延周. 苦酒汤治疗金实不鸣33例[J]. 湖北中医杂志, 1985, 7(5): 39 SHAO Guizhen, WANG Yanzhou. Treatment of 33 cases of golden stagnation with bitter wine decoction[J]. Hubei Journal of Traditional Chinese Medicine, 1985, 7(5): 39
[31] Osa M, Sato A, Sakagami M, et al. Refractory pharyngeal ulceration due to cytomegalovirus in a patient with HIV infection: a case report and literature review[J]. BMC Infect Dis, 2021, 21(1): 252. doi:10.1186/s12879-021-05943-w
[32] Luo L, Huang WH, Ren FF, et al. Pharyngeal ulceration and perforation: a rare manifestation in anti-MDA5 dermatomyositis[J]. Rheumatology(Oxford), 2021, 60(4): e132-e133. doi:10.1093/rheumatology/keaa730
[33] 侯波, 梁程程, 魏东敏, 等. 耳鼻咽喉门诊咽喉良性病变老年患者喉镜观察与嗓音声学分析[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 20-25. doi:10.6040/j.issn.1673-3770.1.2020.111 HOU Bo, LIANG Chengcheng, WEI Dongmin, et al. Laryngoscopy observation and voice acoustic analysis of elderly patients with benign laryngopharyngeal lesions in an ENT out-patient clinic[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 20-25. doi:10.6040/j.issn.1673-3770.1.2020.111
[34] 吴飞虎, 宋任洁, 钱雅琴, 等. 疏风解毒胶囊对急性咽炎大鼠干预作用及机制探讨[J]. 现代中西医结合杂志, 2021, 30(9): 923-925, 935. doi:10.3969/j.issn.1008-8849.2021.09.003 WU Feihu, SONG Renjie, QIAN Yaqin, et al. Intervention effect and mechanism of Shufeng Jiedu capsule on acute pharyngitis rats[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2021, 30(9): 923-925, 935. doi:10.3969/j.issn.1008-8849.2021.09.003
[35] 王思佳, 陈世华, 黄佩蓓. 中药抗慢性咽炎作用机制研究进展分析[J]. 陕西中医药大学学报, 2021, 44(6): 127-131. doi:10.13424/j.cnki.jsctcm.2021.06.026 WANG Sijia, CHEN Shihua, HUANG Peibei. Research progress of anti-chronic pharyngitis mechanism of traditional Chinese medicine[J]. Journal of Shaanxi University of Chinese Medicine, 2021, 44(6): 127-131. doi:10.13424/j.cnki.jsctcm.2021.06.026
[36] 刘克辉, 滕博, 辛丁, 等. 顽固性咽部溃疡中T淋巴细胞亚群的分布[J]. 中国免疫学杂志, 2004, 20(12): 873-874 LIU Kehui, TENG Bo, XIN Ding, et al. T-lymphocyte subsets distribution in recurrent pharyngeal ulcer[J]. Chinese Journal of Immunology, 2004, 20(12): 873-874
[37] 滕博, 金春顺, 辛丁, 等. 顽固性咽部溃疡黏膜中炎细胞的病理学意义[J]. 吉林大学学报(医学版), 2003, 29(2): 182-184. doi:10.13481/j.1671-587x.2003.02.029 TENG Bo, JIN Chunshun, XIN Ding, et al. Pathological significance of cell infiltrationin recurrent pharyngeal ulcer[J]. Journal of Norman Bethune University of Medical Science, 2003, 29(2): 182-184. doi:10.13481/j.1671-587x.2003.02.029
[1] WANG Xin, LIU Qiaoping, YAN Zhanfeng, LIU Siming, ZHU Yajing, DING Qian, ZHANG Ying, TIAN Yuan, ZHANG Jingran. A study on the mechanism of action of the Xiaoqinglong Decoction in treating allergic rhinitis based on network pharmacology [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(5): 46-55.
[2] LIN Yushan, LU Biaoqing. Treatment of sudden seafness by heart and spleen [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(6): 6-11.
[3] YU Yuejin, GU Jingwen, HUANG Wei, LI Pei, HU Hua, HAO Yanan, FAN Yongjiang, GAO Yiyi. Clinical effect of Yunpi Huatan Tongqiao decoction on pediatric snoring disease and immune function [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(6): 56-59.
[4] FAN Zhitao, LIU Chaobing, QIAO Zhenhua.. A case report of mercury poisoning manifesting as odynophagia and pharyngeal ulcer. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(1): 88-89.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd