Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (1): 138-142.doi: 10.6040/j.issn.1673-3770.0.2022.531

• Review • Previous Articles    

Application of optical coherence tomography in idiopathic epiretinal membrane

LIU Jiangchuan1, LI Pengwei1, GUO Jianqiang2, LU Huiqin2   

  1. 1. Department of Ophthalmology, Huanghe Sanmenxia Hospital, Sanmenxia 472000, Henan, China 2. Department of Ophthalmology, Xi'an NO.1 Hospital, Xi'an 710002, Shaanxi, China
  • Published:2024-01-12

PDF (PC)

168

Abstract: Idiopathic epiretinal membrane(iERM)is a medically unexplained ophthalmic disease that can cause a decline in vision quality due to complex and diverse changes in the retina through continuous vitreomacular traction. Optical coherence tomography(OCT)can clearly display the characteristic changes to the retina caused by iERM. In the inner retina, different forms of iERM can produce different visual prognoses. For example, the appearance of ectopic inner foveal layers is a risk factor for vision loss, thickening of the inner nuclear layer can cause visual distortion, and intraretinal cystic spaces may be related to injured Müller cells. In the outer retina, the integrity of the ellipsoid zone, interdigitation zone, and the cotton ball sign can indicate the degree of photoreceptor damage. This article reviews the characteristic changes visible on OCT in patients with iERM.

Key words: Idiopathic epiretinal membrane, Optical coherence tomography, Ellipsoid zone, Ectopic inner foveal layers

CLC Number: 

  • R774.5
[1] Chua PY, Sandinha MT, Steel DH. Idiopathic epiretinal membrane: progression and timing of surgery[J]. Eye(Lond), 2022, 36(3): 495-503. doi:10.1038/s41433-021-01681-0
[2] Duker JS, Kaiser PK, Binder S, et al. The international vitreomacular traction study group classification of vitreomacular adhesion, traction, and macular hole[J]. Ophthalmology, 2013, 120(12): 2611-2619. doi:10.1016/j.ophtha.2013.07.042
[3] Fung AT, Galvin J, Tran T. Epiretinal membrane: a review[J]. Clin Exp Ophthalmol, 2021, 49(3): 289-308. doi:10.1111/ceo.13914
[4] Byon IS, Pak GY, Kwon HJ, et al. Natural history of idiopathic epiretinal membrane in eyes with good vision assessed by spectral-domain optical coherence tomography[J]. Ophthalmologica, 2015, 234(2): 91-100. doi:10.1159/000437058
[5] 林晓芹, 吴苗琴. 特发性视网膜前膜的发病机制及治疗进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(2): 121-128. doi:10.6040/j.issn.1673-3770.0.2019.499 LIN Xiaoqin, WU Miaoqin. Pathogenesis and treatment of idiopathic epiretinal membranes[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(2): 121-128. doi:10.6040/j.issn.1673-3770.0.2019.499
[6] Konidaris V, Androudi S, Alexandridis A, et al. Optical coherence tomography-guided classification of epiretinal membranes[J]. Int Ophthalmol, 2015, 35(4): 495-501. doi:10.1007/s10792-014-9975-z
[7] Taniguchi H, Yoshida I, Sakamoto M, et al. Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration[J]. BMC Ophthalmol, 2021, 21(1): 190. doi:10.1186/s12886-021-01944-0
[8] Govetto A, Lalane RA, Sarraf D, et al. Insights into epiretinal membranes: presence of ectopic inner foveal layers and a new optical coherence tomography staging scheme[J]. Am J Ophthalmol, 2017, 175: 99-113. doi:10.1016/j.ajo.2016.12.006
[9] González-Saldivar G, Berger A, Wong D, et al. Ectopic inner foveal layer classification scheme predicts visual outcomes after epiretinal membrane surgery[J]. Retina, 2020, 40(4): 710-717. doi:10.1097/IAE.0000000000002486
[10] Govetto A, Virgili G, Rodriguez FJ, et al. Functional and anatomical significance of the ectopic inner foveal layers in eyes with idiopathic epiretinal membranes: surgical results at 12 months[J]. Retina, 2019, 39(2): 347-357. doi:10.1097/IAE.0000000000001940
[11] Doguizi S, Sekeroglu MA, Ozkoyuncu D, et al. Clinical significance of ectopic inner foveal layers in patients with idiopathic epiretinal membranes[J]. Eye(Lond), 2018, 32(10): 1652-1660. doi:10.1038/s41433-018-0153-9
[12] Govetto A, Su D, Farajzadeh M, et al. Microcystoid macular changes in association with idiopathic epiretinal membranes in eyes with and without Glaucoma: clinical insights[J]. Am J Ophthalmol, 2017, 181: 156-165. doi:10.1016/j.ajo.2017.06.023
[13] Baek J, Park HY, Lee JH, et al. Elevated M2 macrophage markers in epiretinal membranes with ectopic inner foveal layers[J]. Invest Ophthalmol Vis Sci, 2020, 61(2): 19. doi:10.1167/iovs.61.2.19
[14] Bressler NM, Edwards AR, Antoszyk AN, et al. Retinal thickness on Stratus optical coherence tomography in people with diabetes and minimal or no diabetic retinopathy[J]. Am J Ophthalmol, 2008, 145(5): 894-901. doi:10.1016/j.ajo.2007.12.025
[15] Chalam KV, Bressler SB, Edwards AR, et al. Retinal thickness in people with diabetes and minimal or no diabetic retinopathy: Heidelberg Spectralis optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2012, 53(13): 8154-8161. doi:10.1167/iovs.12-10290
[16] Kang HM, Koh HJ, Lee SC. Visual outcome and prognostic factors after surgery for a secondary epiretinal membrane associated with branch retinal vein occlusion[J]. Graefes Arch Clin Exp Ophthalmol, 2015, 253(4): 543-550. doi:10.1007/s00417-014-2731-2
[17] Okamoto F, Sugiura Y, Okamoto Y, et al. Inner nuclear layer thickness as a prognostic factor for Metamorphopsia after epiretinal membrane surgery[J]. Retina, 2015, 35(10): 2107-2114. doi:10.1097/iae.0000000000000602
[18] Ichikawa Y, Imamura Y, Ishida M. Inner nuclear layer thickness, a biomarker of Metamorphopsia in epiretinal membrane, correlates with tangential retinal displacement[J]. Am J Ophthalmol, 2018, 193: 20-27. doi:10.1016/j.ajo.2018.06.001
[19] Labin AM, Safuri SK, Ribak EN, et al. Müller cells separate between wavelengths to improve day vision with minimal effect upon night vision[J]. Nat Commun, 2014, 5: 4319. doi:10.1038/ncomms5319
[20] 李鹏伟, 苏光明, 刘江川, 等. 光学相干断层扫描血管成像在2型黄斑毛细血管扩张症中的应用进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(1): 140-144. doi: 10.6040/j.issn.1673-3770.0.2021.45 LI Pengwei, SU Guangming, LIU Jiangchuan, et al. Application of optical coherence tomography angiography in macular telangiectasia type 2[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(1): 140-144. doi: 10.6040/j.issn.1673-3770.0.2021.45
[21] Shiode Y, Morizane Y, Toshima S, et al. Surgical outcome of idiopathic epiretinal membranes with intraretinal cystic spaces[J]. PLoS One, 2016, 11(12): e0168555. doi:10.1371/journal.pone.0168555
[22] Güler M, Urfalıo glu S, Damar Güngör E, et al. Clinical and optical coherence tomography analysis of intraretinal microcysts in patients with epiretinal membrane[J]. Semin Ophthalmol, 2021, 36(8): 787-793. doi:10.1080/08820538.2021.1906915
[23] Cobos E, Arias L, Ruiz-Moreno J, et al. Preoperative study of the inner segment/outer segment junction of photoreceptors by spectral-domain optical coherence tomography as a prognostic factor in patients with epiretinal membranes[J]. Clin Ophthalmol, 2013, 7: 1467-1470. doi:10.2147/OPTH.S44837
[24] Spaide RF, Curcio CA. Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model[J]. Retina, 2011, 31(8): 1609-1619. doi:10.1097/IAE.0b013e3182247535
[25] Fernández EJ, Hermann B, Povazay B, et al. Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina[J]. Opt Express, 2008, 16(15): 11083-11094. doi:10.1364/oe.16.011083
[26] Shimozono M, Oishi A, Hata M, et al. The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery[J]. Am J Ophthalmol, 2012, 153(4): 698-704.e1. doi:10.1016/j.ajo.2011.09.011
[27] Watanabe K, Tsunoda K, Mizuno Y, et al. Outer retinal morphology and visual function in patients with idiopathic epiretinal membrane[J]. JAMA Ophthalmol, 2013, 131(2): 172-177. doi:10.1001/jamaophthalmol.2013.686
[28] Stevenson W, Prospero Ponce CM, Agarwal DR, et al. Epiretinal membrane: optical coherence tomography-based diagnosis and classification[J]. Clin Ophthalmol, 2016, 10: 527-534. doi:10.2147/OPTH.S97722
[29] Fernandes TF, Sousa K, Azevedo I, et al. Baseline visual acuity and interdigitation zone as predictors in idiopathic epiretinal membranes: a retrospective cohort study[J]. Eur J Ophthalmol, 2021, 31(3): 1291-1298. doi:10.1177/1120672120932094
[30] Li DQ, Rudkin AK, Altomare F, et al. Predicting progression of untreated macular pucker using retinal surface en face optical coherence tomography[J]. Ophthalmologica, 2020, 243(5): 323-333. doi:10.1159/000497490
[31] Tsunoda K, Watanabe K, Akiyama K, et al. Highly reflective foveal region in optical coherence tomography in eyes with vitreomacular traction or epiretinal membrane[J]. Ophthalmology, 2012, 119(3): 581-587. doi:10.1016/j.ophtha.2011.08.026
[32] Govetto A, Bhavsar KV, Virgili G, et al. Tractional abnormalities of the central foveal bouquet in epiretinal membranes: clinical spectrum and pathophysiological perspectives[J]. Am J Ophthalmol, 2017, 184: 167-180. doi:10.1016/j.ajo.2017.10.011
[33] Brinkmann MP, Michels S, Brinkmann C, et al. Epiretinal membrane surgery outcome in eyes with abnormalities of the central bouquet[J]. Int J Retina Vitreous, 2021, 7(1): 7. doi:10.1186/s40942-020-00279-0
[34] Spaide RF. Closure of an outer lamellar macular hole by vitrectomy: hypothesis for one mechanism of macular hole formation[J]. Retina, 2000, 20(6): 587-590. doi:10.1097/00006982-200006000-00001
[35] Bringmann A, Unterlauft JD, Wiedemann R, et al. Two different populations of Müller cells stabilize the structure of the fovea: an optical coherence tomography study[J]. Int Ophthalmol, 2020, 40(11): 2931-2948. doi:10.1007/s10792-020-01477-3
[1] YUSUFU·Maierhaba, ABULA·Kelimujiang, DING Lin, QIN Yanli, CHEN Xueyi. Fundus changes in high myopia cataract with posterior scleral staphyloma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 107-114.
[2] ZHANG Xiaohan, WEI Li, YANG Kaili, CHEN Haiyan, LI Yansong, WANG Ping. Study on the change of OCTA and its correlation with visual acuity in patients with CSC before and after TCM syndrome differentiation and treatment [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 115-122.
[3] ZHAO Lu, TIAN Huiwen, MENG Bo, WANG Wei, WANG Yanling. Analysis of macular retinal-choroidal thickness changes in patients with internal carotid artery occlusion [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 72-76.
[4] YOU Ran, GUO Xiaoxiao, WANG Wei, CHEN Xi, WANG Yanling. Association of macular retinoschisis severity with choroidal parameters in patients with high myopia [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 83-87.
[5] LEI Min, CHEN Ting, AI Ming. Investigating the correlation between the macular ganglion cell complex and the ratio of deep and superficial vessel density in patients with idiopathic epiretinal membrane [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 104-113.
[6] ZHAO Hongxiao, ZHANG Han. Effect of optical amplification on measurement of ganglion cell complex [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(1): 105-109.
[7] LI Pengwei, SU Guangming, LIU Jiangchuan, MU Yalin. Application of optical coherence tomography angiography in macular telangiectasia type 2 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(1): 140-144.
[8] TANG Feiran, KONG XiangyunOverview,SHEN JiaquanGuidance. Research progress in the role of OCTA in measuring superficial peripapillary vessel density in the diagnosis and treatment of glaucoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(5): 77-82.
[9] YANG Ru, ZHANG Yuguang, XU Xianghui, WU Xuelian, TAO Yuan, TAN Yue. A clinical study on the effect of phacoemulsification on the retinal structure in the macular region of senile cataract [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 97-102.
[10] ZHANG Min,LI Yan. Research progress of optical coherence tomography and angiography in the diagnosis of Alzheimer's disease [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 157-162.
[11] LI Yingying, FENG Jie,LI Wei, DING Tianjiao. Effects of ischemic stroke and other neurodegenerative diseases on RNFL thickness [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 163-168.
[12] ZHANG Xinyu，,LEI Chunyan, ZHANG Meixia. Retinochoriodal changes associated with silicone oil tamponade detected by optical coherence tomography and optical coherence tomography angiography [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(5): 132-136.
[13] Ocular ischemic syndrome(OIS)is usually undiagnosed or misdiagnosed due to its asymptomatic onset, complicated ocular manifestations, and the lack of awareness, and patients with OIS have a higher mortality. Improving the understanding, diagnosis, and treatment of OIS through multidisciplinary collaboration is key to investigating and preventing systemic vascular events as well as decreasing blindness and mortality. This review summarizes the recent advances in the epidemiology, clinical diagnosis, and management of OIS.. Recent ocular ischemic syndrome advancesWANG Luping Overview HUANG Yingxiang, WANG Yanling Guidance Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaAbstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 23-27.
[14] Spectral-domain optical coherence tomography(SD-OCT)was used to measure and observe the characteristics of the subfoveal choroidal thickness(SFCT)in patients with ocular ischemic syndrome(OIS)as well as explore the indicators for early evaluation of OIS. MethodsThis was a retrospective case-control study. Forty-eight patients(48 eyes)were included between January 2017 and January 2020. The patients were divided into two groups: the OIS and the control groups, with each consisting of 24 patients(24 eyes). Their basic information, including age, gender, body mass index(BMI), and the history of diabetes, hypertension, and hyperlipidemia, was collected. SFCT was measured using SD-OCT in EDI mode. The basic data and SFCTs of the two groups were compared. ResultsThere were no significant differences between the ages, gender, BMIs, and the prevalence of diabetes, hypertension, and hyperlipidemia of the two groups(all P>0.05). The mean SFCT of the OIS group was 204.83±27.34 μm, and that of the control group was 226.58±33.49 μm. The differences between the two groups were statistically significant(t=2.464, P=0.018). ConclusionsSFCT was thinner in patients with OIS. SFCT can be used as an indicator for early assessment of OIS.. Analysis of choroidal thickness in patients with ocular ischemic syndromeFU Qiang, WANG Hongxing Department of Ophthalmology, Beijing Chuiyangliu Hospital, Beijing 100022, ChinaAbstract: Objective〓 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 60-63.
[15] ObjectiveTo analyze the association between the classification of blood pressure and retinal vessel diameter measured by spectral-domain optical coherence tomography(SD-OCT). MethodsThis was a cross-sectional study that included 103 patients(103 eyes)with hypertension. Based on the classification of hypertension, the subjects were divided into three groups: the isolated systolic hypertension(ISH)(34 eyes), isolated diastolic hypertension(IDH)(34 eyes), and systolic combined with diastolic hypertension(SDH)(35 eyes)groups. Retinal vessel diameters were measured by SD-OCT. The differences among the central retinal arteriolar equivalents(CRAEs), the central retinal venular equivalents(CRVEs), and the artery-to-vein ratios(AVRs)of the three groups were analyzed. Multivariate logistic regression was performed to evaluate the association between blood pressure and AVR. ResultsThere were significant differences among the CRAEs and AVRs of the three groups(F=4.543, 4.308; P=0.013, 0.016). The CRAE and AVR of the SDH group were the lowest; those of the IDH group were the highest. There were no significant differences among the CRVEs of the three groups(F=0.417, P=0.660). After correction for risk factors, such as gender and age, multivariate logistic regression showed that patients with high systolic blood pressure were more likely to have AVRs of < 0.7 (OR=1.080, P=0.015). ConclusionsAmong the three types of hypertension, SDH was associated with the lowest CRAE and AVR. High systolic pressure is a risk factor for AVRs of < 0.7.. Association between the classification of blood pressure and retinal vessel diameter measured by SD-OCTFENG Xue1, WANG Haiwei2, LI Wensi1, YANG Xintong1, SUN Cun1, ZHAO Yuan1, ZHAO Pengbo1, ZHANG Jianqiang1 1. Department of Ophthalmology, Beijing Moslem People's Hospital, Beijing 100054, China; 2. Department of Ophthalmology, Fuxing Hospital, Capital Medical University, Beijing 100038, ChinaAbstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 64-68.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd