Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (3): 74-81.doi: 10.6040/j.issn.1673-3770.0.2023.177

• Original Article • Previous Articles    

Meta-analysis of the effect of red-light therapy on spherical equivalent, axial length, and choroidal thickness in myopic children

LI Yang, LIU Dong, CAO Wenjie   

  1. Department of Ophthalmology, Jiangding Distric Central Hospital Affiliated Shanghai University of Medicine & Health Science, Shanghai 201800, China
  • Published:2024-06-04

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Abstract: Objective To explore the effect of red-light therapy on equivalent sphere, axial length and choroidal thickness in myopic children. Methods We searched PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wanfang, CBM, Vip, and Clinical trial registry on red-light therapy for myopia control published from the establishment of the database to October 28, 2022. The Cochrane Handbook was used for risk of bias and quality evaluation of the included literature, and Revman 5.3 software was used for Meta-analysis, and STATA 12.0 software was used to detect publication bias. Results A total of 1425 eyes from nine articles were included, of which five were randomized controlled trials and three were control studies. Meta-analysis showed that the inhibitory effect of red-light on the increase in spherical equivalent(SE)and axial length(AL)was better than that of the single-focus spectacles group(SE: WMD=0.41, 95%CI: 0.29-0.54, I2=65%, P<0.000 01; AL: WMD=-0.21, 95%CI: -026 - 0.15, I2=73%, P<0.000 01), the increase of choroidal thickness(CHT)in red-light therapy group was superior to that in single-focus spectacles group(WMD=26.05, 95%CI: 22.11-29.99, I2=45%, P<0.000 01). Conclusion The control effect of red-light therapy was better than that of the single-focus spectacles, but long-term use of adverse reations still need to be further observed.

Key words: Red-light therapy, Myopia, Axis length, Spherical equivalent, Choroidal thickness, Meta-analysis

CLC Number: 

  • R778.1
[1] 熊翩翩, 王佳琳, 孙姣, 等. 高度近视豹纹状眼底视网膜脉络膜血流改变及相关性分析[J]. 山东大学耳鼻喉眼学报, 2023, 37(2): 114-121. doi:10.6040/j.issn.1673-3770.0.2022.421 XIONG Pianpian, WANG Jialin, SUN Jiao, et al. Analysis of retinal choroidal blood flow changes and correlation with tessellated fundus in highly myopic eyes[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 114-121. doi:10.6040/j.issn.1673-3770.0.2022.421
[2] Morgan IG, French AN, Ashby RS, et al. The epidemics of myopia: Aetiology and prevention[J]. Prog Retin Eye Res, 2018, 62: 134-149. doi:10.1016/j.preteyeres.2017.09.004
[3] Cooper J, Tkatchenko AV. A review of current concepts of the etiology and treatment of myopia[J]. Eye Contact Lens, 2018, 44(4): 231-247. doi:10.1097/ICL.0000000000000499
[4] Huang PC, Hsiao YC, Tsai CY, et al. Protective behaviours of near work and time outdoors in myopia prevalence and progression in myopic children: a 2-year prospective population study[J]. Br J Ophthalmol, 2020, 104(7): 956-961. doi:10.1136/bjophthalmol-2019-314101
[5] Yang XW, Yang YF, Wang Y, et al. Protective effects of sunlight exposure against PRK-induced myopia in infant rhesus monkeys[J]. Ophthalmic Physiol Opt, 2021, 41(4): 911-921. doi:10.1111/opo.12826
[6] Rucker F. Monochromatic and white light and the regulation of eye growth[J]. Exp Eye Res, 2019, 184: 172-182. doi:10.1016/j.exer.2019.04.020
[7] Zhu QR, Liu LQ. Relationship between myopia and light exposure[J]. Sichuan Da Xue Xue Bao Yi Xue Ban, 2021, 52(6): 901-906. doi:10.12182/20211160205
[8] Hung LF, Arumugam B, She ZH, et al. Narrow-band, long-wavelength lighting promotes hyperopia and retards vision-induced myopia in infant rhesus monkeys[J]. Exp Eye Res, 2018, 176: 147-160. doi:10.1016/j.exer.2018.07.004
[9] Wu PC, Chen CT, Lin KK, et al. Myopia prevention and outdoor light intensity in a school-based cluster randomized trial[J]. Ophthalmology, 2018, 125(8): 1239-1250. doi:10.1016/j.ophtha.2017.12.011
[10] Xiong F, Mao T, Liao HF, et al. Orthokeratology and low-intensity laser therapy for slowing the progression of myopia in children[J]. Biomed Res Int, 2021, 2021: 8915867. doi:10.1155/2021/8915867
[11] 闫艺, 薛文娟, 赵延军, 等. 650 nm半导体激光控制青少年近视进展的研究[J]. 临床眼科杂志, 2021, 29(2): 132-137 YAN Yi, XUE Wenjuan, ZHAO Yanjun, et al. Effect of 650 nm semiconductor laser on juvenile myopia control[J]. Journal of Clinical Ophthalmology, 2021, 29(2): 132-137
[12] Dong J, Zhu ZT, Xu HF, et al. Myopia control effect of repeated low-level red-light therapy in Chinese children: a randomized, double-blind, controlled clinical trial[J]. Ophthalmology, 2023, 130(2): 198-204. doi:10.1016/j.ophtha.2022.08.024
[13] Tian L, Cao K, Ma DL, et al. Investigation of the efficacy and safety of 650 nm low-level red light for myopia control in children: a randomized controlled trial[J]. Ophthalmol Ther, 2022, 11(6): 2259-2270. doi:10.1007/s40123-022-00585-w
[14] Zhou L, Xing C, Qiang W, et al. Low-intensity, long-wavelength red light slows the progression of myopia in children: an Eastern China-based cohort[J]. Ophthalmic Physiol Opt, 2022, 42(2): 335-344. doi:10.1111/opo.12939
[15] Jiang Y, Zhu ZT, Tan XP, et al. Effect of repeated low-level red-light therapy for myopia control in children: a multicenter randomized controlled trial[J]. Ophthalmology, 2022, 129(5): 509-519. doi:10.1016/j.ophtha.2021.11.023
[16] Xiong F, Mao T, Liao HF, et al. Orthokeratology and low-intensity laser therapy for slowing the progression of myopia in children[J]. Biomed Res Int, 2021, 2021: 8915867. doi:10.1155/2021/8915867
[17] 刘丹. 红光治疗控制儿童近视进展的临床研究[D]. 大理: 大理大学, 2022. doi:10.27811/d.cnki.gdixy.2022.000271
[18] 赖伟霞, 贾亦悦, 张雨艺, 等. 低强度红光在低龄高度近视儿童中的疗效研究[J]. 眼科新进展, 2022, 42(9): 727-730. doi:10.13389/j.cnki.rao.2022.0149 LAI Weixia, JIA Yiyue, ZHANG Yuyi, et al. Efficacy of low-level red light in young children with high myopia[J]. Recent Advances in Ophthalmology, 2022, 42(9): 727-730. doi:10.13389/j.cnki.rao.2022.0149
[19] 陈培正, 张宏亮, 王晶晶, 等. 艾尔兴哺光仪控制青少年、儿童近视疗效分析[J]. 实用中西医结合临床, 2018, 18(10): 63-64. doi:10.13638/j.issn.1671-4040.2018.10.030 CHEN Peizheng, ZHANG Hongliang, WANG Jingjing, et al. Analysis of therapeutic effect of Aierxing light feeding instrument on myopia control of teenagers and children[J]. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine, 2018, 18(10): 63-64. doi:10.13638/j.issn.1671-4040.2018.10.030
[20] Zadnik K, Mutti DO. Outdoor activity protects against childhood myopia-let the Sun shine In[J]. JAMA Pediatr, 2019, 173(5): 415-416. doi:10.1001/jamapediatrics.2019.0278
[21] Chen HY, Wang W, Liao Y, et al. Low-intensity red-light therapy in slowing myopic progression and the rebound effect after its cessation in Chinese children: a randomized controlled trial[J]. Albrecht Von Graefes Arch Fur Klin Und Exp Ophthalmol, 2023, 261(2): 575-584. doi:10.1007/s00417-022-05794-4
[22] Dai LL, Yang WC, Qin XY, et al. Serum metabolomics profiling and potential biomarkers of myopia using LC-QTOF/MS[J]. Exp Eye Res, 2019, 186: 107737. doi:10.1016/j.exer.2019.107737
[23] Jówko E, P aszewski M, Cie liński M, et al. The effect of low level laser irradiation on oxidative stress, muscle damage and function following neuromuscular electrical stimulation. A double blind, randomised, crossover trial[J]. BMC Sports Sci Med Rehabil, 2019, 11: 38. doi:10.1186/s13102-019-0147-3
[24] Yuan JS, Wu SJ, Wang YW, et al. Inflammatory cytokines in highly myopic eyes[J]. Sci Rep, 2019, 9(1): 3517. doi:10.1038/s41598-019-39652-x
[25] 尤冉, 郭笑霄, 王薇, 等. 高度近视患者黄斑区视网膜劈裂分型与脉络膜特征分析[J]. 山东大学耳鼻喉眼学报, 2023, 37(3): 83-87. doi:10.6040/j.issn.1673-3770.0.2022.528 YOU Ran, GUO Xiaoxiao, WANG Wei, et al. Association of macular retinoschisis severity with choroidal parameters in patients with high myopia[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 83-87. doi:10.6040/j.issn.1673-3770.0.2022.528
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