Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (3): 67-73.doi: 10.6040/j.issn.1673-3770.0.2023.013

• Original Article • Previous Articles    

A meta-analysis of the correlation between platelet-lymphocyte ratio and prognosis of laryngeal squamous cell carcinoma

WANG Kaijian, CHEN Xuesheng, WANG Wei   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Qidong People's Hospital/Qidong Hospital, Nantong University, Qidong 226200, Jiangsu, China
  • Published:2024-06-04

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Abstract: Objective To investigate the correlation between platelet-lymphocyte ratio(PLR)and the prognosis of patients with laryngeal squamous cell carcinoma(LSCC)by Meta-analysis, and to predict the prognosis of patients. To provide evidence-based evidence for optimizing treatment strategies. Methods PubMed, Web of Science, CNKI, VIP and Wan fang databases were searched for studies on the correlation between PLR and the prognosis of LSCC. The raw data of prognostic indicators were extracted, and Meta-analysis was performed using Stata12.0 statistical software. Results A total of 14 studies were included. The results of Meta-analysis showed that overall survival of patients with higher PLR(HR=1.46,95%CI:1.34-1.58,P<0.001), recurrence-free survival(HR=1.37, 95%CI: 1.25-1.50, P<0.001), progression-free survival(HR=1.52, 95%CI: 1.11-2.08, P<0.001), disease-free survival(HR=1.15, 95%CI: 1.04-1.27, P<0.001), and the worse(HR=1.24, 95%CI: 1.12-1.38, P<0.001). Conclusion The prognosis of patients is closely related to PLR value. The higher the PLR value, the worse the prognosis of patients, PLR value is an effective indicator to preliminarily judge the prognosis of patients.

Key words: Platelet-lymphocyte ratio, Laryngeal squamous cell carcinoma, Prognosis, Meta-analysis

CLC Number: 

  • R739.65
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