甲状腺相关性眼病活动性客观评价的研究进展

doi:10.6040/j.issn.1673-3770.0.2023.235

Abstract

Abstract: Thyroid-associated ocular disease(TAO)is an autoimmune disease characterized by the infiltration of periorbital tissues. As TAO progresses, different signs and manifestations may occur, such as eyelid retraction, eyelid edema, periorbital soft-tissue swelling, extraocular muscle involvement, and optic nerve dysfunction, which seriously affect patients' daily life and their physical and mental health. The results vary of studies to date of the objective and accurate evaluation of TAO. In addition to examining domestic and foreign reports, this study conducts a systematic summary and analysis of the current status of objective evaluations of TAO activity.

Key words: Thyroid-associated ophthalmopathy, Activity, Optical coherence tomography, Magnetic resonance imaging, Single photon emission computed tomography computed tomography

CLC Number:

R777.5

HUANG Jiao, PENG Changfu. Progress in objective evaluation of thyroid-related eye disease activity[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 171-178.

References

[1] Bartalena L, Piantanida E, Gallo D, et al. Epidemiology, natural history, risk factors, and prevention of Graves' orbitopathy[J]. Front Endocrinol(Lausanne), 2020, 11: 615993. doi:10.3389/fendo.2020.615993
[2] Wickwar S, McBain HB, Ezra DG, et al. Which factors are associated with quality of life in patients with Graves' orbitopathy presenting for orbital decompression surgery?[J]. Eye(Lond), 2015, 29(7): 951-957. doi:10.1038/eye.2015.76
[3] Ferløv-Schwensen C, Brix TH, Hegedüs L. Death by suicide in Graves' disease and Graves' orbitopathy: a nationwide Danish register study[J]. Thyroid, 2017, 27(12): 1475-1480. doi:10.1089/thy.2017.0365
[4] Szelog J, Swanson H, Sniegowski MC, et al. Thyroid eye disease[J]. Mo Med, 2022, 119(4):343-350
[5] Mourits MP, Koornneef L, Wiersinga WM, et al. Clinical criteria for the assessment of disease activity in Graves' ophthalmopathy: a novel approach[J]. Br J Ophthalmol, 1989, 73(8): 639-644. doi:10.1136/bjo.73.8.639
[6] 蔡秋月, 陈智毅, 李晨钟, 等. 核磁共振眼外肌与同侧脑白质信号强度比值对甲状腺相关性眼病活动性评判价值的研究[J]. 中华内分泌代谢杂志, 2018, 34(2): 106-111. doi:10.3760/cma.j.issn.1000-6699.2018.02.004 CAI Qiuyue, CHEN Zhiyi, LI Chenzhong, et al. The value of the signal intensity ratio of the extraocular muscle and the ipsilateral white matter of the MRI in the evaluation of the activity of thyroid-associated ophthalmopathy[J]. Chinese Journal of Endocrinology and Metabolism, 2018, 34(2): 106-111. doi:10.3760/cma.j.issn.1000-6699.2018.02.004
[7] Ceylanoglu KS, Eser NA, Sen EM. Choroidal structural evaluation in inactive Graves' ophthalmopathy[J]. Photodiagnosis Photodyn Ther, 2022, 39: 103012. doi:10.1016/j.pdpdt.2022.103012
[8] Del Noce Chiara, Vagge Aldo, Massimo Nicolò, et al. Evaluation of choroidal thickness and choroidal vascular blood flow in patients with thyroid-associated orbitopathy(TAO)using SD-OCT and Angio-OCT[J]. Graefe's Archive for Clinical and Experimental Ophthalmology, 2020, 258(5):1103-1107. doi:10.1007/s00417-020-04616-9
[9] Jiang CZ, Deng ZL, Huang J, et al. Monitoring and predicting treatment response of extraocular muscles in grave's orbitopathy by ^{99 m}Tc-DTPA SPECT/CT[J]. Front Med(Lausanne), 2021, 8: 791131. doi:10.3389/fmed.2021.791131
[10] 张加男, 于璟, 袁欣. 99Tc m-DTPA SPECT/CT眼眶显像眼外肌SUV max在甲状腺相关性眼病活动度评估中的临床应用[J]. 中华核医学与分子影像杂志, 2021, 41(9)525-530. doi: 10.3760/cma.j.cn321828-20200415-00151 ZHANG Jianan, YU Jing, YUAN Xin. Application of SUV max of extraocular muscle on 99Tc m-DTPA orbital SPECT/CT for evaluating activity of thyroid associated ophthalmopathy[J]. Chinese Journal of Nuclear Medicine and Molecular Imaging, 2021, 41(9)525-530. doi: 10.3760/cma.j.cn321828-20200415-00151
[11] Gontarz-Nowak K, Szychlińska M, Matuszewski W, et al. Current knowledge on Graves' orbitopathy[J]. J Clin Med, 2020, 10(1): 16. doi:10.3390/jcm10010016
[12] 中华医学会眼科学分会眼整形眼眶病学组, 中华医学会内分泌学分会甲状腺学组. 中国甲状腺相关眼病诊断和治疗指南(2022年)[J]. 中华眼科杂志, 2022, 58(9): 646-668. doi: 10.3760/cma.j.cn112142-20220421-00201 Oculoplastic and Orbital Disease Group of Chinese Ophthalmological Society of Chinese Medical Association, Thyroid Group of Chinese Society of Endocrinology of Chinese Medical Association. Chinese guideline on the diagnosis and treatment of thyroid-associated ophthalmopathy(2022)[J]. Chinese Journal of Ophthalmology, 2022, 58(9): 646-668. doi: 10.3760/cma.j.cn112142-20220421-00201
[13] 吉玲, 牟宁, 许诺. 甲状腺相关眼病患者泪腺参数眼眶磁共振成像的临床研究[J]. 国际眼科杂志, 2023, 23(4): 644-647. doi: 10.3980/j.issn.1672-5123.2023.4.22 JI Ling, MU Ning, XU Nuo. Clinical evaluation of lacrimal gland parameters in patients with thyroid-associated ophthalmopathy using orbital magnetic resonance imagining[J]. International Eye Science, 2023, 23(4): 644-647. doi: 10.3980/j.issn.1672-5123.2023.4.22
[14] Kirsch EC, Kaim AH, De Oliveira MG, et al. Correlation of signal intensity ratio on orbital MRI-TIRM and clinical activity score as a possible predictor of therapy response in Graves' orbitopathy—a pilot study at 1.5 T[J]. Neuroradiology, 2010, 52(2): 91-97. doi:10.1007/s00234-009-0590-z
[15] Politi LS, Godi C, Cammarata G, et al. Magnetic resonance imaging with diffusion-weighted imaging in the evaluation of thyroid-associated orbitopathy: getting below the tip of the iceberg[J].Eur Radiol, 2014, 24(5): 1118-1126. doi:10.1007/s00330-014-3103-3
[16] 黄凯, 林晓鑫, 罗耀升, 等. Dixon与SPAIR技术在甲状腺相关性眼病中应用的对比研究[J]. 磁共振成像, 2023, 14(8): 51-57. doi: 10.12015/issn.1674-8034.2023.08.008 HUANG Kai, LIN Xiaoxin, LUO Yaosheng, et al. Comparative study of Dixon and SPAIR techniques in thyroid-associated ophthalmopathy[J]. Chinese Journal of Magnetic Resonance Imaging, 2023, 14(8): 51-57. doi: 10.12015/issn.1674-8034.2023.08.008
[17] 刘刚, 朱蓉蓉, 盛迅伦, 等. 磁共振脂肪定量技术评价甲状腺相关眼病的活动性[J]. 中华实验眼科杂志, 2019, 37(12): 976-981. doi: 10.3760/cma.j.issn.2095-0160.2019.12.008 LIU Gang, ZHU Rongrong, SHENG Xunlun, et al. Evaluation of thyroid-associated ophthalmopathy activity by using magnetic resonance fat quantification technology[J]. Chinese Journal of Experimental Ophthalmology, 2019, 37(12): 976-981. doi: 10.3760/cma.j.issn.2095-0160.2019.12.008
[18] 冯晓婷, 罗耀升, 李章芳, 等. 核磁共振脂肪定量对评估甲状腺相关性眼病的临床价值初探[J]. 中华内分泌代谢杂志, 2020, 36(8): 690-695. doi:10.3760/cma.j.cn311282-20200109-00010 FENG Xiaoting, LUO Yaosheng, LI Zhangfang, et al. The exploration on clinical value of MRI fat quantification in patients with thyroid associated ophthalmopathy[J]. Chinese Journal of Endocrinology and Metabolism, 2020, 36(8): 690-695. doi:10.3760/cma.j.cn311282-20200109-00010
[19] Salz DA, de Carlo TE, Adhi M, et al. Select features of diabetic retinopathy on swept-source optical coherence tomographic angiography compared with fluorescein angiography and normal eyes[J]. JAMA Ophthalmol, 2016, 134(6): 644-650. doi:10.1001/jamaophthalmol.2016.0600
[20] 郭娑, 杨培增. OCT及OCTA应用于非感染性葡萄膜炎的研究进展[J]. 中华眼科杂志, 2023, 59(8): 677-681. doi: 10.3760/cma.j.cn112142-20220905-00433 GUO Suo, YANG Peizeng. Research progress of optical coherence tomography and optical coherence tomography angiography in noninfectious uveitis: a review[J]. Chinese Journal of Ophthalmology, 2023, 59(8): 677-681. doi: 10.3760/cma.j.cn112142-20220905-00433
[21] 张丹, 赵军, 张娟美, 等. 早期活动性Graves眼病患者黄斑中心凹下不同脉络膜分层厚度分析[J]. 国际眼科杂志, 2019, 19(12): 2150-2152. doi:10.3980/j.issn.1672-5123.2019.12.36 ZHANG Dan, ZHAO Jun, ZHANG Juanmei, et al. Analysis of different choroidal stratification thickness under macular fovea in patients with early Graves ophthalmopathy[J]. International Eye Science, 2019, 19(12): 2150-2152. doi:10.3980/j.issn.1672-5123.2019.12.36
[22] 田雨, 郭珊, 王松田, 等. 脉络膜厚度的临床研究进展[J]. 中华眼科医学杂志(电子版), 2018, 8(4): 181-186. doi:10.3877/cma.j.issn.2095-2007.2018.04.007 TIAN Yu, GUO Shan, WANG Songtian, et al. Progress in the clinical study of choroidal thick ness[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2018, 8(4): 181-186. doi:10.3877/cma.j.issn.2095-2007.2018.04.007
[23] Lai F, Iao T, Ng D, et al. Choroidal thickness in thyroid-associated orbitopathy[J]. Clin Exp Ophthalmol, 2019, 47: 918-924. doi:10.1111/ceo.13525
[24] 张新媛, 邱冰洁, 王艳红, 等. 正常人脉络膜厚度分布特征及肥厚型脉络膜诊断界线值[J]. 中华实验眼科杂志, 2022, 40(6)548-555. doi: 10.3760/cma.j.cn115989-20220401-00127 ZHANG Xinyuan, QIU Bingjie, WANG Yanhong, et al. Distribution characteristics of choroidal thickness in normal population and the diagnostic cut-off value for pachychoroid[J]. Chinese Journal of Experimental Ophthalmology, 2022, 40(6)548-555. doi: 10.3760/cma.j.cn115989-20220401-00127
[25] Yu N, Zhang Y, Kang L, et al. Analysis in choroidal thickness in patients with graves ophthalmopathy using spectral-domain optical coherence tomography[J]. Journal of Ophthalmology, 2019,(2018): 3529395. doi: 10.1155/2018/3529395
[26] Cagiltay E, Akay F, Demir O, et al. The increment of choroidal thickness in euthyroid Graves' ophthalmopathy: is it an early sign of venous congestion?[J]. J Ophthalmol, 2018, 2018: 1-6. doi:10.1155/2018/5891531
[27] Gul A, Basural E, Ozturk HE. Comparison of choroidal thickness in patients with active and stable thyroid eye disease[J]. Arquivos Brasileiros De Oftalmol, 2019, 82(2): 124-128. doi:10.5935/0004-2749.20190019
[28] Ye L, Zhou SS, Yang WL, et al. Retinal microvasculature alteration in active thyroid-associated ophthalmopathy[J]. Endocr Pract, 2018, 24(7): 658-667. doi:10.4158/ep-2017-0229
[29] Wu YF, Tu YH, Wu CM, et al. Reduced macular inner retinal thickness and microvascular density in the early stage of patients with dysthyroid optic neuropathy[J]. Eye Vis(Lond), 2020, 7: 16. doi:10.1186/s40662-020-00180-9
[30] Zhang T, Xiao W, Ye HJ, et al. Peripapillary and macular vessel density in dysthyroid optic neuropathy: an optical coherence tomography angiography study[J]. Invest Ophthalmol Vis Sci, 2019, 60(6): 1863. doi:10.1167/iovs.18-25941
[31] Akpolat C, Kurt MM, Yılmaz M, et al. Analysis of foveal and parafoveal microvascular density and retinal vessel caliber alteration in inactive Graves' ophthalmopathy[J]. J Ophthalmol, 2020, 2020: 1-8. doi:10.1155/2020/7643737
[32] Yu Lanchu, Jiao Qin, Cheng Yu, et al. Evaluation of retinal and choroidal variations in thyroid-associated ophthalmopathy using optical coherence tomography angiography[J]. BMC Ophthalmology, 2020, 20(1):421. doi: 10.1186/s12886-020-01692-7
[33] 郭悦, 姚稚明, 刘秀芹, 等. 99Tcm-DTPA SPECT/CT眼眶显像评价甲状腺相关性眼病活动性: 与临床活动性评分及MRI的对比分析[J]. 国际放射医学核医学杂志, 2019(5): 416-421. doi: 10.3760/cma.j.issn.1673-4114.2019.05.006 GUO Yue, YAO Zhiming, LIU Xiuqin, et al. The activity of thyroid-associated ophthalmopathy assessed by 99Tcm-DTPA orbit SPECT/CT: comparison with clinical activity score and MRI[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2019(5): 416-421. doi: 10.3760/cma.j.issn.1673-4114.2019.05.006
[34] 蒋承志, 李新辉, 赵敏, 等. ^{99 m}Tc-DTPA眼眶SPECT/CT对甲状腺相关性眼病泪腺炎症的评估价值[J]. 中南大学学报(医学版), 2019, 44(3)322-328. doi 10.11817/j.issn.1672-7347.2019.03.014 JIANG Chengzhi, LI Xinhui, ZHAO Min, et al. Efficacy of ^{99 m}Tc-DTPA orbital SPECT/CT on the evaluation of lacrimal gland inflammation in patients with thyroid associated ophthalmopathy[J]. Journal of Central South University(Medical Science), 2019, 44(3)322-328. doi: 10.11817/j.issn.1672-7347.2019.03.014
[35] 张雪辉, 孔飚, 肖国有, 等. SPECT/CT显像对脊柱良恶性病变诊断的增益价值[J]. 中华核医学与分子影像杂志, 2016, 36(2): 156-160. doi:10.3760/cma.j.issn.2095-2848.2016.02.013 ZHANG Xuehui, KONG Biao, XIAO Guoyou, et al. The added value of SPECT/CT imaging for diagnosing benign and malignant lesions of spine[J]. Chinese Journal of Nuclear Medicine and Molecular Imaging, 2016, 36(2): 156-160. doi:10.3760/cma.j.issn.2095-2848.2016.02.013
[36] Harhalaki MA, Alevizaki C, Georgiou E, et al. Increased Tc-99m DTPA uptake in active Graves' ophthalmopathy and pretibial myxoedema[J]. J Nucl Med, 1983, 24(2): 174-176.
[37] Galuska L, Leovey A, Szucs-Farkas Z, et al. SPECT using ^{99 m}Tc-DTPA for the assessment of disease activity in Graves' ophthalmopathy: a comparison with the results from MRI[J]. Nucl Med Commun, 2002, 23(12): 1211-1216. doi:10.1097/00006231-200212000-00010
[38] 蒋承志, 李新辉, 邓豪余, 等. ^{99 m}Tc-DTPA眼眶SPECT/CT显像非靶区及阈值的选择在甲状腺相关性眼病中的应用[J]. 中南大学学报(医学版), 2018, 43(8): 869-874. doi:10.11817/j.issn.1672-7347.2018.08.008 JIANG Chengzhi, LI Xinhui, DENG Haoyu, et al. Nontarget area and threshold selection in ^{99 m}Tc-DTPA orbital SPECT/CT imaging in thyroid associated ophthalmopathy[J]. Journal of Central South University(Medical Science), 2018, 43(8): 869-874. doi:10.11817/j.issn.1672-7347.2018.08.008
[39] Dong Feng, Li Lin, Bian YanZhu, et al. Standardized uptake value using thyroid quantitative SPECT/CT for the diagnosis and evaluation of Graves' disease: a prospective multicenter study[J]. BioMed Research International, 2019. doi:10.1155/2019/7589853
[40] Szumowski P, Abdelrazek S, Zukowski Ł, et al. Efficacy of 99mTc-DTPA SPECT/CT in diagnosing orbitopathy in Graves' disease[J]. BMC Endocr Disord, 2019, 19(1): 10. doi:10.1186/s12902-019-0340-0
[41] 朱明娟, 邢凯, 亢泽峰, 等. 甲状腺相关性眼病的诊断及治疗进展[J]. 山东大学耳鼻喉眼学报, 2018, 32(5)110-113, 116. doi: 10.6040/j.issn.1673-3770.0.2018.034 ZHU Mingjuan, XING Kai, KANG Zefeng, et al. Diagnosis and treatment of thyroid-associated ophthalmopathy[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5)110-113, 116. doi: 10.6040/j.issn.1673-3770.0.2018.034
[42] Kahaly GJ. Imaging in thyroid-associated orbitopathy[J]. Eur J Endocrinol, 2001: 107-118. doi:10.1530/eje.0.1450107
[43] Chang TC, Huang KM, Hsiao YL, et al. Relationships of orbital computed tomographic findings and activity scores to the prognosis of corticosteroid therapy in patients with Graves' ophthalmopathy[J]. Acta Ophthalmol Scand, 1997, 75(3): 301-304. doi:10.1111/j.1600-0420.1997.tb00779.x
[44] 危昆桥, 魏锐利, 马晓晔, 等. 甲状腺相关眼病眼眶CT定量测量及亚型分析[J]. 中国实用眼科杂志, 2014(2): 161-165. doi: 10.3760/cma.j.issn.1006-4443.2014.02.018 WEI Kunqiao, WEI Ruili, MA Xiaoye, et al. Thyroid associated ophthalmopathy: CT imaging of extraocular muscle coronal area and subtypes analysis[J]. Chinese Journal of Practical Ophthalmology, 2014(2): 161-165. doi: 10.3760/cma.j.issn.1006-4443.2014.02.018
[45] Le Moli R, Pluchino A, Muscia V, et al. Graves' orbitopathy: extraocular muscle/total orbit area ratio is positively related to the Clinical Activity Score[J]. Eur J Ophthalmol, 2012, 22(3): 301-308. doi:10.5301/ejo.5000018
[46] 拓秀, 信中, 闫钟钰, 等. CT眼眶结构定量分析在甲状腺相关性眼病活动性评价中的作用[J]. 眼科, 2018, 27(5): 333-337. doi:10.13281/j.cnki.issn.1004-4469.2018.05.003 TUO Xiu, XIN Zhong, YAN Zhongyu, et al. Quantitative analysis of orbit structure on computed tomography to assess the activity of thyroid associated ophthalmopathy[J]. China Industrial Economics, 2018, 27(5): 333-337. doi:10.13281/j.cnki.issn.1004-4469.2018.05.003
[47] 南贤秀. 球后脂肪CT值在中重度活动期TAO中的应用及LOF技术的临床研究应用[D]. 太原: 山西医科大学.
[48] 赫义兰, 那旭, 张春柱, 等. 能谱CT物质定量技术对甲状腺相关性眼病的应用价值[J]. 中国中医眼科杂志, 2022, 32(12)945-948. doi: 10.13444/j.cnki.zgzyykzz.2022.12.005 HE Yilan, NA Xu, ZHANG Chunzhu, et al. Application value of spectral computed tomography quantitative technique in thyroid-associated ophthalmopathy[J]. Chinese Journal of Chinese Ophthalmology, 2022, 32(12)945-948. doi: 10.13444/j.cnki.zgzyykzz.2022.12.005
[49] Konuk O, Onaran Z, Ozhan Oktar S, et al. Intraocular pressure and superior ophthalmic vein blood flow velocity in Graves' orbitopathy: relation with the clinical features[J].Graefe's Arch Clin Exp Ophthalmol, 2009, 247(11): 1555-1559. doi:10.1007/s00417-009-1144-0
[50] Monteiro MLR, Angotti-Neto H, Benabou JE, et al. Color Doppler imaging of the superior ophthalmic vein in different clinical forms of Graves' orbitopathy[J]. Jpn J Ophthalmol, 2008, 52(6): 483-488. doi:10.1007/s10384-008-0594-y
[51] Somer D, Özkan SB, Özdemir H, et al. Colour Doppler imaging of superior ophthalmic vein in thyroid-associated eye disease[J]. Jpn J Ophthalmol, 2002, 46(3): 341-345. doi:10.1016/S0021-5155(02)00485-9
[52] Monteiro MLR, Moritz RBS, Angotti Neto H, et al. Color Doppler imaging of the superior ophthalmic vein in patients with Graves' orbitopathy before and after treatment of congestive disease[J]. Clinics(Sao Paulo), 2011, 66(8): 1329-1334. doi:10.1590/s1807-59322011000800004
[53] Jamshidian-Tehrani M, Nabavi A, Kasaee A, et al. Color Doppler imaging in thyroid eye disease and its correlation to disease activity[J]. Orbit, 2019, 38(6): 440-445. doi:10.1080/01676830.2018.1556704
[54] Pérez-López M, Sales-Sanz M, Rebolleda G, et al. Retrobulbar ocular blood flow changes after orbital decompression in Graves' ophthalmopathy measured by color Doppler imaging[J]. Invest Ophthalmol Vis Sci, 2011, 52(8): 5612. doi:10.1167/iovs.10-6907

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