Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (3): 55-60.doi: 10.6040/j.issn.1673-3770.0.2023.504

• Original Article • Previous Articles    

Clinical observation of compacept in the treatment of diabetes mellitus with CRVO-ME high reflex point

BAO Ying1,2, LIU Zhigao2, JANG Pengfei3, CUI Wenxuan1, ZHENG Xiaoxia1, YANG Mengyao1, SI Mingwei1, WANG Yu2,4, WANG Hong1   

  1. 1. Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China2. Jinan Aier Eye Hospital, Jinan 250100, Shandong, China3. Department of Ophthalmology, Yantai Yuhuangding Hospital, Yantai 264099, Shandong, China4. The Second People's Hospital of Jinan, Jinan 250001, Shandong, China
  • Published:2024-06-04

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Abstract: Objective To observe the changes in hyperreflective dots(HRD)in the retina of patients with non-ischemic central retinal vein occlusion-macular edema(CRVO-ME)treated with conbercept. Methods Eighty cases and 80 eyes of non-ischemic CRVO-ME patients were selected and divided into 40 cases(40 eyes)in the diabetic group and 40 cases(40 eyes)in the non-diabetic group according to the presence or absence of diabetes mellitus. Best corrected visual acuity(BCVA), central macular thickness(CMT)and the number of HRDs in the inner and outer retinal layers were compared and analysed in the two groups before and 1, 3 and 6 months after intravitreal injection of conbercept(IVC)treatment. Results At 3 and 6 months after IVC, BCVA in the non-diabetic group was significantly higher than that in the diabetic group(F=4.106,P=0.046;F=10.474,P=0.002), and CMT was significantly lower at 6 months after IVC(F=10.688,P=0.002). There was no significant difference in the amount of HRD in the inner retina between the two groups before and after IVC(F=1.608,P=0.209), but there was a significant difference in the amount of HRD in the outer retina(F=4.290,P=0.042). Conclusion IVC is effective in the treatment of non-ischemic CRVO-ME. HRD in the outer layer of the retina can be used as an imaging marker to monitor the inflammatory response and assess prognosis. The long-term therapeutic effect of non-ischemic CRVO-ME in diabetic group is worse than in non-diabetic group. Therefore, more attention should be paid to the long-term follow-up of diabetic patients to avoid serious complications.

Key words: Diabetes, Non-ischemic central retinal vein occlusion, Intravitreal injection, Macular edema, High reflective points

CLC Number: 

  • R587.1
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