Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (6): 136-142.doi: 10.6040/j.issn.1673-3770.0.2024.491

• Meta Analysis • Previous Articles    

Meta-analysis of the clinical efficacy and safety of proton pump inhibitors versus gastric mucosal protective agents in the treatment of laryngopharyngeal reflux disease

MI Xueqin1, LI Songzhe2, DENG Yingjie2, LI Shengyang2, XIAO Dingqi2, FAN Lei1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Chengdu Sixth People's Hospital, Chengdu 610051, Sichuan, China2. College of Sports Medicine and Rehabilitation, North Sichuan Medical College, Nanchong 637000, Sichuan, China
  • Published:2024-12-13

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Abstract: Objective To analyse the clinical effectiveness and safety of proton pump inhibitors(PPIs)and gastric mucosal protectors in the treatment of laryngopharygeal reflux disease(LPRD)by Meta-analysis. Methods The CNKI, Wanfang, VIP, CBM, PubMed, Embase, Cochrane library, Web of Science databases on PPIs, gastric mucosal protectors and LPRD were retrieved up to September 2024. Two reviewers screened the literature, extracted data and performed meta-analysis of studies that met the quality criteria using R4.3.1 software. Results Six randomised controlled trials(RCT)were included, and the results of the meta-analysis showed that the response rate of LPRD with PPIs was better than that of gastric mucosal protectors ［RR=1.19(95%CI:1.10-1.29, P<0.000 1)］; the incidence of adverse reactions of PPI treatment in LPRD was not significantly different from that of gastric mucosal protectors ［RR=0.51(95%CI:0.18-1.41, P=0.19)］; the differences were statistically significant. Conclusion In short-term treatment with an LPRD course of no more than 4 weeks, PPIs significantly improved clinical efficacy compared with gastric mucosal protectors, but the incidence of adverse effects was not significantly different from that of gastric mucosal protectors.

Key words: Proton pump inhibitor, Gastric mucosal protective agents, Laryngopharygeal reflux disease, Meta-analysis

CLC Number: 

  • R766.5
[1] 中华耳鼻咽喉头颈外科杂志编辑委员会咽喉组, 中华医学会耳鼻咽喉头颈外科学分会咽喉学组, 中华医学会耳鼻咽喉头颈外科学分会嗓音学组. 咽喉反流性疾病诊断与治疗专家共识(2022年,修订版)[J]. 中华耳鼻咽喉头颈外科杂志, 2022, 57(10): 1149-1172. doi:10.3760/cma.j.cn115330-20220711-00428 Subspecialty Group of Laryngopharyngology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Subspecialty Group of Laryngopharyngology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association; Subspecialty Group of Voice, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association. Experts consensus on diagnosis and treatment of laryngopharyngeal reflux disease(2022, revision)[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2022, 57(10): 1149-1172. doi:10.3760/cma.j.cn115330-20220711-00428
[2] 黄凤玲. 难治性LPRD与焦虑抑郁及自主神经功能的相关性研究[D]. 南宁: 广西医科大学, 2021
[3] 鲁明, 蔡继壹, 洪泽生, 等. 改变生活及饮食方式在咽喉反流性疾病治疗中的作用研究[J]. 中国耳鼻咽喉头颈外科, 2024, 31(4): 255-259. doi:10.16066/j.1672-7002.2024.04.011
[4] 梁志成,覃冠锻. 咽喉反流性疾病和负面情绪相关性研究进展 [J]. 中国医学文摘(耳鼻咽喉科学), 2024, 39(3): 118-121. doi:10.19617/j.issn1001-1307. 2024. 03. 118 LIANG Zhicheng,QIN Guanduan.Research advances in laryngopharyngeal reflux disease and negative mood associations[J].Chinese Medical Digest(Otorhinolaryngology), 2024, 39(3): 118-121. doi:10.19617/j.issn1001-1307. 2024. 03. 118
[5] 王颖, 周佳青. 慢性咽喉炎和反流性食管炎的相关性研究[J]. 中国耳鼻咽喉颅底外科杂志, 2011, 17(6): 476-480
[6] 崔玉兰, 周忠信. 质子泵抑制剂在反流性咽喉炎治疗中效果[J]. 中国医学文摘(耳鼻咽喉科学), 2021, 36(6): 128-129. doi:10.19617/j.issn1001-1307.2021.06.128 CUI Yulan, ZHOU Zhongxin. The effect of proton pump inhibitors in the treatment of reflux pharyngitis[J]. Chinese Medical Digest(Otorhinolaryngology), 2021, 36(6): 128-129. doi:10.19617/j.issn1001-1307.2021.06.128
[7] Gatta L, Vaira D, Sorrenti G, et al. Meta-analysis: the efficacy of proton pump inhibitors for laryngeal symptoms attributed to gastro-oesophageal reflux disease[J]. Aliment Pharmacol Ther, 2007, 25(4): 385-392. doi:10.1111/j.1365-2036.2006.03213.x
[8] 张吉翔, 董卫国, 邱实, 等. 质子泵抑制剂治疗胃食管反流性咽喉炎的Meta分析[J]. 胃肠病学和肝病学杂志, 2012, 21(9): 834-840. doi:10.3969/j.issn.1006-5709.2012.09.016 ZHANG Jixiang, DONG Weiguo, QIU Shi, et al. The Meta-analysis for the effects of proton pump inhibitors on the treatment of gastroesophageal reflux laryngitis[J]. Chinese Journal of Gastroenterology and Hepatology, 2012, 21(9): 834-840. doi:10.3969/j.issn.1006-5709.2012.09.016
[9] 王焱, 刘英, 李芳, 等. 质子泵抑制剂的临床应用研究进展[J]. 中华保健医学杂志, 2021, 23(4): 415-416, 419. doi:10.3969/j.issn.1674-3245.2021.04.031
[10] 田鸣. 莫沙必利联合铝碳酸镁治疗胆汁反流性胃炎的疗效及安全性[J]. 黑龙江医药科学, 2018, 41(5): 68-69. doi:10.3969/j.issn.1008-0104.2018.05.031
[11] 毕冠芳. 质子泵抑制剂对反流性咽喉炎的治疗作用及安全性评价[J]. 糖尿病天地, 2023(7): 61-62. doi:10.3969/j.issn.1672-7851.2023.07.031
[12] 刘德刚. 质子泵抑制剂治疗反流性咽喉炎的临床疗效及其安全性[J]. 中国医学文摘(耳鼻咽喉科学), 2022, 37(1): 108-109, 136. doi:10.19617/j.issn1001-1307.2022.01.108 LIU Degang. Clinical efficacy and safety of proton pump inhibitors in the treatment of reflux laryngitis[J]. Chinese Medical Digest(Otorhinolaryngology), 2022, 37(1): 108-109, 136. doi:10.19617/j.issn1001-1307.2022.01.108
[13] 朱路路. 质子泵抑制剂治疗反流性咽喉炎的疗效及对患者症状的影响研究[J]. 科学养生, 2021, 24(9): 170. doi:10.3969/j.issn.1672-9714.2021.09.162
[14] 徐玉国. 质子泵抑制剂对反流性咽喉炎的治疗作用分析 [J]. 中国医学文摘(耳鼻咽喉科学), 2021, 36(1): 152-153,156.doi:10.19617/j.issn1001-1307. 2021. 01. 152 XU Yuguo. Therapeutic effect of proton pump inhibitors on reflux laryngitis[J]. Chinese Medical Digest(Otorhinolaryngology), 2021, 36(1): 152-153,156. doi:10.19617/j.issn1001-1307. 2021. 01. 152
[15] 王旭燕. 质子泵抑制剂应用于老年反流性咽喉炎治疗的效果研究[J]. 特别健康, 2018(13): 28-29. doi:10.3969/j.issn.2095-6851.2018.13.034
[16] 任玉莲. 泮托拉唑联合铝碳酸镁治疗反流性咽喉炎30例临床疗效研究[J]. 湖北科技学院学报(医学版), 2014, 28(4): 293-296 REN Yulian. Clinical efficacy research of treatment of pantoprazole with hydrotalcite for 30 patients with laryngopharyngeal reflux[J]. Journal of Hubei University of Science and Technology(Medical Sciences), 2014, 28(4): 293-296
[17] 张雅菲, 纪洋洋, 胡伟琦, 等. 康复新液联合埃索美拉唑治疗幽门螺杆菌阴性的反流性咽喉炎[J]. 中国眼耳鼻喉科杂志, 2019, 19(5): 328-331. doi:10.14166/j.issn.1671-2420.2019.05.010 ZHANG Yafei, JI Yangyang, HU Weiqi, et al. Curative effect of Kangfuxin combined with esomeprazole for Helicobacter pylori negative patients with laryngopharyngeal reflux disease[J]. Chinese Journal of Ophthalmology and Otorhinolaryngology, 2019, 19(5): 328-331. doi:10.14166/j.issn.1671-2420.2019.05.010
[18] 王荣国, 宋晓飞, 陈红耀, 等. 喉部上皮细胞形态、黏膜防御和炎症相关性基因在反流性咽喉炎患者的表达探究[J]. 中国耳鼻咽喉头颈外科, 2019, 26(9): 500-503. doi:10.16066/j.1672-7002.2019.09.009 WANG Rongguo, SONG Xiaofei, CHEN Hongyao, et al. Laryngeal epithelial cell morphology and expression of mucosal defense and inflammation-related genes in patients with reflux laryngitis[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2019, 26(9): 500-503. doi:10.16066/j.1672-7002.2019.09.009
[19] 陈旭东. 雷贝拉唑联合莫沙必利治疗胃食管反流性咽喉炎的效果评价[J]. 中国保健营养, 2021. 31(32): 190.
[20] 郭顺水. 雷贝拉唑与莫沙必利联用在胃食管反流性咽喉炎患者中的效果观察[J]. 北方药学, 2021, 18(8): 162, 166. doi:10.3969/j.issn.1672-8351.2021.08.074
[21] Lin RJ, Sridharan S, Smith LJ, et al. Weaning of proton pump inhibitors in patients with suspected laryngopharyngeal reflux disease[J]. Laryngoscope, 2018, 128(1): 133-137. doi:10.1002/lary.26696
[22] Lapeña JFF Jr, Ambrocio GMC, Carrillo RJD. Validity and reliability of the Filipino reflux symptom index[J]. J Voice, 2017, 31(3): 387. doi:10.1016/j.jvoice.2016.09.013
[23] Mössner J. The indications, applications, and risks of proton pump inhibitors[J]. Dtsch Arztebl Int, 2016, 113(27/28): 477-483. doi:10.3238/arztebl.2016.0477
[24] Yadlapati R, Kahrilas PJ. The “dangers” of chronic proton pump inhibitor use[J]. J Allergy Clin Immunol, 2018, 141(1): 79-81. doi:10.1016/j.jaci.2017.06.017
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