Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 92-97.doi: 10.6040/j.issn.1673-3770.1.2021.576

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Research progress on the correlation between nasal bacterial microbiome and chronic rhinosinusitis with nasal polyps

YU LonggangOverview,JIANG Yan   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, the Affiliated Hospital of Qingdao University/Otorhinolaryngology Head and Neck Surgery Key Laboratory of Shandong Province, Qingdao 266000, Shandong, China
  • Published:2022-06-15

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Abstract: Chronic sinusitis with nasal polyp(CRSwNP)is a refractory subtype of chronic sinusitis. The pathophysiological mechanism of CRSwNP is still unclear; however, bacteria are hypothesized to play an important role in its pathogenesis. The microbiome is one of the new perspectives in human health research, including respiratory diseases. With the development of next-generation sequencing technology, the nasal bacterial microbiome of CRSwNP has been further elucidated. Changes in bacterial abundance and diversity in the nasal cavity may be related to the type of inflammation, concomitant diseases and prognosis of CRSwNP. Nasal bacteria are also promising in the diagnosis and treatment of CRSwNP. This review summarizes the current findings and understanding of the correlation between the bacterial microbiome of the nasal cavity and CRSwNP.

Key words: Microbiology, Nasal Polyps, Sinusitis, RNA, Ribosomal, 16S

CLC Number: 

  • R765.4
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