Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (3): 92-97.doi: 10.6040/j.issn.1673-3770.1.2021.576

Previous Articles     Next Articles

Research progress on the correlation between nasal bacterial microbiome and chronic rhinosinusitis with nasal polyps

YU LonggangOverview,JIANG Yan   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, the Affiliated Hospital of Qingdao University/Otorhinolaryngology Head and Neck Surgery Key Laboratory of Shandong Province, Qingdao 266000, Shandong, China
  • Published:2022-06-15

Abstract: Chronic sinusitis with nasal polyp(CRSwNP)is a refractory subtype of chronic sinusitis. The pathophysiological mechanism of CRSwNP is still unclear; however, bacteria are hypothesized to play an important role in its pathogenesis. The microbiome is one of the new perspectives in human health research, including respiratory diseases. With the development of next-generation sequencing technology, the nasal bacterial microbiome of CRSwNP has been further elucidated. Changes in bacterial abundance and diversity in the nasal cavity may be related to the type of inflammation, concomitant diseases and prognosis of CRSwNP. Nasal bacteria are also promising in the diagnosis and treatment of CRSwNP. This review summarizes the current findings and understanding of the correlation between the bacterial microbiome of the nasal cavity and CRSwNP.

Key words: Microbiology, Nasal Polyps, Sinusitis, RNA, Ribosomal, 16S

CLC Number: 

  • R765.4
[1] Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020[J]. Rhinology, 2020, 58(Suppl S29): 1-464. doi:10.4193/Rhin20.600.
[2] Meltzer EO, Hamilos DL, Hadley JA, et al. Rhinosinusitis: establishing definitions for clinical research and patient care[J]. J Allergy Clin Immunol, 2004, 114(6 Suppl): 155-212. doi:10.1016/j.jaci.2004.09.029.
[3] Stevens WW, Lee RJ, Schleimer RP, et al. Chronic rhinosinusitis pathogenesis[J]. J Allergy Clin Immunol, 2015, 136(6): 1442-1453. doi:10.1016/j.jaci.2015.10.009.
[4] Ramakrishnan VR, Hauser LJ, Frank DN. The sinonasal bacterial microbiome in health and disease[J]. Curr Opin Otolaryngol Head Neck Surg, 2016, 24(1): 20-25. doi:10.1097/MOO.0000000000000221.
[5] 程雷, 邱昌余. 微生物组和感染在慢性鼻-鼻窦炎发病中的作用[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 1-3. doi: doi: 10.6040/j.issn.1673-3770.1.2018.009. CHENG Lei, QIU Changyu. The role of microbiome and infection in the pathogenesis of chronic rhinosinusitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(3): 1-3. doi: doi: 10.6040/j.issn.1673-3770.1.2018.009.
[6] Mahdavinia M, Keshavarzian A, Tobin MC, et al. A comprehensive review of the nasal microbiome in chronic rhinosinusitis(CRS)[J]. Clin Exp Allergy, 2016, 46(1): 21-41. doi:10.1111/cea.12666.
[7] Wagner Mackenzie B, Waite DW, Hoggard M, et al. Bacterial community collapse: a meta-analysis of the sinonasal microbiota in chronic rhinosinusitis[J]. Environ Microbiol, 2017, 19(1): 381-392. doi:10.1111/1462-2920.13632.
[8] Suzaki H, Watanabe S, Pawankar R. Rhinosinusitis and asthma-microbiome and new perspectives[J]. Curr Opin Allergy Clin Immunol, 2013, 13(1): 45-49. doi:10.1097/ACI.0b013e32835b34f6.
[9] Paramasivan S, Bassiouni A, Shiffer A, et al. The international sinonasal microbiome study: a multicentre, multinational characterization of sinonasal bacterial ecology[J]. Allergy, 2020, 75(8): 2037-2049. doi:10.1111/all.14276.
[10] Chalermwatanachai T, Vilchez-Vargas R, Holtappels G, et al. Chronic rhinosinusitis with nasal polyps is characterized by dysbacteriosis of the nasal microbiota[J]. Sci Rep, 2018, 8(1): 7926. doi:10.1038/s41598-018-26327-2.
[11] Gan WG, Zhang HT, Yang FJ, et al. The influence of nasal microbiome diversity and inflammatory patterns on the prognosis of nasal polyps[J]. Sci Rep, 2021, 11(1): 6364. doi:10.1038/s41598-021-85292-5.
[12] Gan WG, Yang FJ, Tang YP, et al. The difference in nasal bacterial microbiome diversity between chronic rhinosinusitis patients with polyps and a control population[J]. Int Forum Allergy Rhinol, 2019, 9(6): 582-592. doi:10.1002/alr.22297.
[13] Cho SW, Kim DY, Choi S, et al. Microbiome profiling of uncinate tissue and nasal polyps in patients with chronic rhinosinusitis using swab and tissue biopsy[J]. PLoS One, 2021, 16(4): e0249688. doi:10.1371/journal.pone.0249688.
[14] Grayson JW, Hopkins C, Mori, et al. Contemporary classification of chronic rhinosinusitis beyond polyps vs no polyps: a review[J]. JAMA Otolaryngol Head Neck Surg, 2020, 146(9): 831-838. doi:10.1001/jamaoto.2020.1453.
[15] 娄鸿飞, 王成硕. 慢性鼻窦炎分型研究进展[J]. 山东大学耳鼻喉眼学报, 2018, 32(3): 10-13. doi: 10.6040/j.issn.1673-3770.1.2018.008. LOU Hongfei, WANG Chengshuo. Progress in classification of chronic sinusitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(3): 10-13. doi: 10.6040/j.issn.1673-3770.1.2018.008.
[16] Tai JH, Han MS, Kwak J, et al. Association between microbiota and nasal mucosal diseases in terms of immunity[J]. Int J Mol Sci, 2021, 22(9): 4744. doi:10.3390/ijms22094744.
[17] van Zele T, Gevaert P, Watelet JB, et al. Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis[J]. J Allergy Clin Immunol, 2004, 114(4): 981-983. doi:10.1016/j.jaci.2004.07.013.
[18] Lan F, Zhang N, Gevaert E, et al. Viruses and bacteria in Th2-biased allergic airway disease[J]. Allergy, 2016, 71(10): 1381-1392. doi:10.1111/all.12934.
[19] Hulse KE, Stevens WW, Tan BK, et al. Pathogenesis of nasal polyposis[J]. Clin Exp Allergy, 2015, 45(2): 328-346. doi:10.1111/cea.12472.
[20] Rom D, Bassiouni A, Eykman E, et al. The association between disease severity and microbiome in chronic rhinosinusitis[J]. Laryngoscope, 2019, 129(6): 1265-1273. doi:10.1002/lary.27726.
[21] Kuhar HN, Tajudeen BA, Mahdavinia M, et al. Relative abundance of nasal microbiota in chronic rhinosinusitis by structured histopathology[J]. Int Forum Allergy Rhinol, 2018, 8(12): 1430-1437. doi:10.1002/alr.22192.
[22] Abbas EE, Li C, Xie A, et al. Distinct clinical pathology and microbiota in chronic rhinosinusitis with nasal polyps endotypes[J]. Laryngoscope, 2021, 131(1): E34-E44. doi:10.1002/lary.28858.
[23] Feng TT, Miao P, Liu B, et al. Sinus microbiota in patients with eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps[J]. Front Cell Infect Microbiol, 2021, 11: 672355. doi:10.3389/fcimb.2021.672355.
[24] Fokkens WJ, Lund V, Bachert C, et al. EUFOREA consensus on biologics for CRSwNP with or without asthma[J]. Allergy, 2019, 74(12): 2312-2319. doi:10.1111/all.13875.
[25] Phillips KM, Talat R, Caradonna DS, et al. Quality of life impairment due to chronic rhinosinusitis in asthmatics is mediated by asthma control[J]. Rhinology, 2019, 57(6): 430-435. doi:10.4193/Rhin19.207.
[26] Wu DW, Li L, Zhang M, et al. Two inflammatory phenotypes of nasal polyps and comorbid asthma[J]. Ann Allergy Asthma Immunol, 2017, 118(3): 318-325. doi:10.1016/j.anai.2016.12.018.
[27] Stevens WW, Peters AT, Hirsch AG, et al. Clinical characteristics of patients with chronic rhinosinusitis with nasal polyps, asthma, and aspirin-exacerbated respiratory disease[J]. J Allergy Clin Immunol Pract, 2017, 5(4): 1061-1070.e3. doi:10.1016/j.jaip.2016.12.027.
[28] Fazlollahi M, Lee TD, Andrade J, et al. The nasal microbiome in asthma[J]. J Allergy Clin Immunol, 2018, 142(3): 834-843.e2. doi:10.1016/j.jaci.2018.02.020.
[29] Ramakrishnan VR, Hauser LJ, Feazel LM, et al. Sinus microbiota varies among chronic rhinosinusitis phenotypes and predicts surgical outcome[J]. J Allergy Clin Immunol, 2015, 136(2): 334-342.e1. doi:10.1016/j.jaci.2015.02.008.
[30] Hauser LJ, Ir D, Kingdom TT, et al. Investigation of bacterial repopulation after sinus surgery and perioperative antibiotics[J]. Int Forum Allergy Rhinol, 2016, 6(1): 34-40. doi:10.1002/alr.21630.
[31] Cleland EJ, Bassiouni A, Vreugde S, et al. The bacterial microbiome in chronic rhinosinusitis: Richness, diversity, postoperative changes, and patient outcomes[J]. Am J Rhinol Allergy, 2016, 30(1): 37-43. doi:10.2500/ajra.2016.30.4261.
[32] Jain R, Hoggard M, Biswas K, et al. Changes in the bacterial microbiome of patients with chronic rhinosinusitis after endoscopic sinus surgery[J]. Int Forum Allergy Rhinol, 2017, 7(1): 7-15. doi:10.1002/alr.21849.
[33] 吴玉彬, 孙炎, 黄振校, 等. 慢性鼻窦炎伴鼻息肉手术前后鼻腔微生物组学的变化[J]. 临床耳鼻咽喉头颈外科杂志, 2020, 34(12): 1097-1102. doi:10.13201/j.issn.2096-7993.2020.12.010. WU Yubin, SUN Yan, HUANG Zhenxiao, et al. The impact of endoscopic sinus surgery on sinonasal microbiome of chronic rhinosinusitis with nasal polyps[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2020, 34(12): 1097-1102. doi:10.13201/j.issn.2096-7993.2020.12.010.
[34] Wang JC, Moore CA, Epperson MV, et al. Association of the sinonasal bacterial microbiome with clinical outcomes in chronic rhinosinusitis: a systematic review[J]. Int Forum Allergy Rhinol, 2020, 10(4): 433-443. doi:10.1002/alr.22524.
[35] Gan WG, Zhang HT, Yang FJ, et al. The influence of nasal bacterial microbiome diversity on the pathogenesis and prognosis of chronic rhinosinusitis patients with polyps[J]. Eur Arch Oto Rhino Laryngol, 2020, 278(prepublish): 1-14. doi:10.1007/s00405-020-06370-4.
[36] Zhao Y, Chen JR, Hao Y, et al. Predicting the recurrence of chronic rhinosinusitis with nasal polyps using nasal microbiota[J]. Allergy, 2022, 77(2): 540-549. doi:10.1111/all.15168.
[37] Bourdillon AT, Edwards HA. Review of probiotic use in otolaryngology[J]. Am J Otolaryngol, 2021, 42(2): 102883. doi:10.1016/j.amjoto.2020.102883.
[38] Psaltis AJ, Wormald PJ. Therapy of sinonasal microbiome in CRS: a critical approach[J]. Curr Allergy Asthma Rep, 2017, 17(9): 59. doi:10.1007/s11882-017-0726-x.
[39] de Boeck I, Wittouck S, Martens K, et al. The nasal mutualist Dolosigranulum pigrum AMBR11 supports homeostasis via multiple mechanisms[J]. iScience, 2021, 24(9): 102978. doi:10.1016/j.isci.2021.102978.
[40] de Rudder C, Garcia-Tímermans C, de Boeck I, et al. Lacticaseibacillus casei AMBR2 modulates the epithelial barrier function and immune response in a donor-derived nasal microbiota manner[J]. Sci Rep, 2020, 10: 16939. doi:10.1038/s41598-020-73857-9.
[1] TIAN Jun, LIU Liangfa, BAI Jiaqi. Cervical vertebral osteomyelitis secondary to necrotizing otitis externa:a case report and review of literature [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 1-5.
[2] AO Tian,CHENG Lei. An endotype study of chronic rhinosinusitis with nasal polyps and precise control and treatment under the guidance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 7-14.
[3] XIONG Panhui, SHEN Yang,YANG Yucheng. Advancements in the diagnosis and treatment of chronic sinusitis based on phenotypes and endotypes [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 15-19.
[4] YAO Shuang,LOU Hongfei. Advances in endotypes and precision medicine in chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 20-29.
[5] LIANG Xu,SHI Li. Research progress in biologic targeted drug therapy for chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 30-35.
[6] SHI Shuai, ZHENG Quan,CHENG Lei. Research advances of dupilumab in the treatment of chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 36-42.
[7] WANG Huan, HU Li,YU Hongmeng. Research progress of olfactory dysfunction in chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 43-49.
[8] YI Ruonan,CHEN Fuquan. Eosinophils and Olfactory Dysfunction [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 50-55.
[9] GU Yu, WAN Xin,XIAO Zi'an. The interaction between neutrophils and eosinophils in chronic rhinosinusitis and the implications on treatment options [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 56-63.
[10] LIN Hai, ZHU Ying,ZHANG Weitian. The roles of ion channels in the pathogenesis of chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 64-70.
[11] QIAO Xinjie,. Research progress on the signal transduction pathway and other factors related to epithelial-mesenchymal transformation in chronic rhinosinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 71-77.
[12] HUANG Danyi, ZHANG Ting,CHEN Jing, ZHANG Wei. Progress of research regarding the role of the epithelial barrier in chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 78-83.
[13] LI Jiani, ZHU Dongdong,MENG Cuida. The role of epigenetics in the pathogenesis of chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 84-91.
[14] CAO Xuan,XIAO Xuping, LI Yunqiu. Advances in the application of hyaluronic acid in chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 104-109.
[15] WANG Na,CHAI Xiangbin. Research progress on prostate-derived ETS factor in asthma and inflammatory diseases of the nasal mucosa [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 136-141.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] HE Shou-huan,CHEN Bin,YIN Shan-kai,SU Kai-ming,JIANG Xiao . Morphological changes of the upper airway in OSAHS patients with UPPP
[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(5): 385 -388 .
[2] SONG Xi-cheng,ZHANG Qing-quan,XIA Yong-hong,LIU Lu-yi, YU Lu-xin,WANG Gao,JIANG Xiu-liang . Post-operative ICU monitoring and nursing for patients with OSAHS[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(5): 389 -392 .
[3] XUE Wei-guo,SUN Jie,JIN Zheng,SHI Wen-bin,XIN Lu,LIN Guo-Jing,LI Jia-yun . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(4): 300 -303 .
[4] ZHANG Qing-quan,LI Xin-min,WANG Qiang,WANG Yong-fu . Some experience of the endoscopy treatment of maxillary sinus lesion with the canine tooth fossa approach[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(1): 38 -39 .
[5] DONG Pin,LI Xiao-yan,TU Li-qiang,MENG Qing-hong,WANG Sang,XIE Jin,JIANG Yan . Reconstruction for advanced hypopharyngeal carcinoma and laryngeal recurrent carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(5): 385 -387 .
[6] JIANG Shao-hong,ZHU Yu-hong,WANG Qiang,SONG Xi-cheng . Intractable primary epistaxis: a report of 101 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2007, 21(6): 542 -544 .
[7] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(1): 74 -77 .
[8] LEIXun, LIU Qianghe, KONG Zhongyu, XIANG Qiu, GENG WANping, HUANG Hui, DONG Yiyuan, LIU Fangxian. ARelationship between expression of Survivin and radiosensitization effect of EGCG in xenotransplanted nasopharyngeal carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(1): 6 -9 .
[9] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2009, 23(2): 73 -74 .
[10] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(01): 29 -33 .