JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (5): 76-78.doi: 10.6040/j.issn.1673-3770.0.2015.184

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Establishment and application of model of chronic rhinosinusitis in mice

WANG Zhiyuan, ZHANG Gehua   

  1. Department of Otolaryngology & Head and Neck Surgery, Guangzhou 510630, Guangdong, China
  • Received:2015-05-10 Revised:2015-09-21 Online:2015-10-16 Published:2015-10-16

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Abstract: Chronic rhinosinusitis(CRS) is a common chronic inflammatory disease of the upper respiratory tract, which seriously affects the patients' quality of life. Because of its uncertain pathogenesis, the curative effect is not satisfactory. Animal model of CRS is the ideal means for study of the human CRS pathological mechanism and curative effect. Mice are currently common CRS animals. The main content of the review includes research progress of the mice CRS-building methods, the evaluation index and application status of the model.

Key words: Nasal polyps, Animal model, Mouse, Literature review, Chronic rhinosinusitis

CLC Number: 

  • R765.4
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