Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (2): 57-60.doi: 10.6040/j.issn.1673-3770.1.2020.012

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Efficacy of 0.1% diclofenac sodium eye drops post-SMILE

JIANG Yang, LI Ying, CUI Gen   

  1. Department of Ophthalmology, Peking Union Medical College Hospital/Chinese Academy of Medical Sciences, Beijing 100730, China
  • Published:2020-04-07

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Abstract: Objective To study the safety, efficacy, and tolerability of 0.1% diclofenac sodium eye drops after the small incision lenticule extraction(SMILE)procedure. Methods Two groups were observed, including 60 patients(60 eyes)with myopia. Thirty patients(30 eyes)were treated with topical compound tobramycin eye drops 4 times daily for 10 days as the control group. Meanwhile, 30 patients(30 eyes)were treated with topical compound tobramycin eye drops 4 times daily for 10 days, and diclofenac sodium eye drops 4 times daily for 20 days. All of the patients were observed in the preoperative and postoperative periods. The visual acuity, intraocular pressure, topography and adverse reactions were recorded at 10 d and after 1 month. The differences between the 2 groups were analyzed by the single factor analysis of variance(one-way ANOVA). Results There was no significant difference between the 2 groups in terms of uncorrected visual acuity at 10 d(P=0.12,F=2.50). However, there was after 1-month(P=0.001,F=29.78). There were no significant differences between the intraocular pressure values pre-operation, and postoperatively at 10 d and 1 month(P=0.45,0.97,0.66,F=0.56,<0.001,0.19). There were no significant differences between the 2 groups in the SRI and SAI values pre-operation and at 1 month in the SRI index(P=0.32, 0.05, 0.07,F=1.01, 3.86, 3.27). However, there was a significant difference in the SAI value 1-month post the operation (P=0.01,F=7.70). Eight patients(26.67%)in the diclofenac sodium eye drops group suffered from transient mild eye pain. However, this discomfort was relieved after a short time. Conclusion Diclofenac sodium eye drops can be an effective treatment combined with corticoids after SMILE. They are safe and were satisfactory in the recovery of visual acuity and ocular surface regularity.

Key words: Small incision lenticule extraction, Glucocorticoid, Non-steroidal, Diclofenac sodium eye drops, Uncorrected visual acuity

CLC Number: 

  • R778
[1] Miao HM, Tian M, Xu Y, et al. Visual outcomes and optical quality after femtosecond laser small incision lenticule extraction: an 18-month prospective study[J]. J Refract Surg, 2015, 31(11): 726-731. doi:10.3928/1081597X-20151021-01.
[2] Pedersen IB, Ivarsen A, Hjortdal J. Three-year results of small incision lenticule extraction for high myopia: refractive outcomes and aberrations[J]. J Refract Surg, 2015, 31(11): 719-724. doi:10.3928/1081597X-20150923-11.
[3] Ishii R, Shimizu K, Igarashi A, et al. Influence of femtosecond lenticule extraction and small incision lenticule extraction on corneal nerve density and ocular surface: a 1-year prospective, confocal, microscopic study[J]. J Refract Surg, 2015, 31(1): 10-15. doi:10.3928/1081597X-20141218-01.
[4] Sekundo W, Gertnere J, Bertelmann T, et al. One-year refractive results, contrast sensitivity, high-order aberrations and complications after myopic small-incision lenticule extraction(ReLEx SMILE)[J]. Albrecht Von Graefes Arch Fur Klinische Und Exp Ophthalmol, 2014, 252(5): 837-843. doi:10.1007/s00417-014-2608-4.
[5] 董子献. 飞秒激光角膜基质透镜切除(ReLEx)创伤愈合及机制研究[D]. 上海: 复旦大学, 2012. DONG Zixian. The study of corneal wound healing and mechanism after femtosecond laser-assisted refractive lenticule extraction[D]. Shanghai: Fudan University, 2012.
[6] Qi H, Hao YS, Xia YJ, et al. Regression-related factors before and after laser in situ keratomileusis[J]. Ophthalmologica, 2006, 220(4): 272-276. doi:10.1159/000093083.
[7] Razeghinejad MR, Katz LJ. Steroid-induced iatrogenic Glaucoma[J]. Ophthalmic Res, 2012, 47(2): 66-80. doi:10.1159/000328630.
[8] Razeghinejad MR, Myers JS, Katz LJ. Iatrogenic Glaucoma secondary to medications[J]. Am J Med, 2011, 124(1): 20-25. doi:10.1016/j.amjmed.2010.08.011.
[9] Wu D, Wang Y, Zhang L, et al. Corneal biomechanical effects: small-incision lenticule extraction versus femtosecond laser-assisted laser in situ keratomileusis[J]. J Cataract Refract Surg, 2014, 40(6): 954-962. doi:10.1016/j.jcrs.2013.07.056.
[10] Sambhi RS, Sambhi GDS, Mather R, et al. Dry eye after refractive surgery: a meta-analysis[J]. Can J Ophthalmol, 2019,20: doi:10.1016/j.jcjo.2019.07.005.
[11] Sun Y, Zhang T, Liu ML, et al. Early corneal wound healing response after small incision lenticule extraction[J]. Cornea, 2019, 38(12): 1582-1588. doi:10.1097/ICO.0000000000002105.
[12] Liu YC, Teo EP, Lwin NC, et al. Early corneal wound healing and inflammatory responses after SMILE: comparison of the effects of different refractive corrections and surgical experiences[J]. J Refract Surg, 2016, 32(5): 346-353. doi:10.3928/1081597X-20160217-05.
[13] Zhang C, Ding H, He M, et al. Comparison of early changes in ocular surface and inflammatory mediators between femtosecond lenticule extraction and small-incision lenticule extraction[J]. PLoS One, 2016, 11(3): e0149503. doi:10.1371/journal.pone.0149503.
[14] Gao SH, Li SQ, Liu LP, et al. Early changes in ocular surface and tear inflammatory mediators after small-incision lenticule extraction and femtosecond laser-assisted laser in situ keratomileusis[J]. PLoS One, 2014, 9(9): e107370. doi:10.1371/journal.pone.0107370.
[15] Dong ZX, Zhou XT, Wu JH, et al. Small incision lenticule extraction(SMILE)and femtosecond laser LASIK: comparison of corneal wound healing and inflammation[J]. Br J Ophthalmol, 2014, 98(2): 263-269. doi:10.1136/bjophthalmol-2013-303415.
[16] Wilson SE, de Oliveira RC. Pathophysiology and treatment of diffuse lamellar keratitis[J]. J Refract Surg, 2020, 36(2): 124-130. doi:10.3928/1081597X-20200114-01.
[17] 乔明艳. 国内双氯芬酸钠制剂开发概况[J]. 实用药物与临床, 2010, 13(5): 379-380. doi:10.3969/j.issn.1673-0070.2010.05.026.
[18] 宋秋利, 许淑云, 李忠诚. 双氯芬酸钠滴眼液在YAG后囊切开术后的应用观察[J]. 国际眼科杂志, 2011, 11(8): 1483-1484. doi:10.3969/j.issn.1672-5123.2011.08.060. SONG Qiuli, XU Shuyun, LI Zhongcheng. Observation on application of diclofenac sodium eye drops after YAG posterior capsulotomy[J]. International Journal of Ophthalmology, 2011, 11(8): 1483-1484. doi:10.3969/j.issn.1672-5123.2011.08.060.
[19] 周凤, 刘春民, 韩冰, 等. 儿童斜视术后应用典必舒和双氯芬酸钠眼药水的疗效观察[J]. 国际眼科杂志, 2007, 7(1): 212-214. doi:10.3969/j.issn.1672-5123.2007.01.063. ZHOU Feng, LIU Chunming, HAN Bing, et al. Comparison of effects of topical tobradex and diclofe-nac after strabismus surgery[J]. International Journal of Ophthalmology, 2007, 7(1): 212-214. doi:10.3969/j.issn.1672-5123.2007.01.063.
[20] 罗艳, 冯劼, 鲁铭, 等. 双氯芬酸钠滴眼液在Toric人工晶状体植入手术围手术期的应用[J]. 国际眼科杂志, 2013, 13(5): 880-882. doi:10.3980/j.issn.1672-5123.2013.05.11. LUO Yan, FENG Jie, LU Ming, et al. Clinical assessment of diclofenac sodium eye drops in toric intraocular Lens implantation[J]. International Eye Science, 2013, 13(5): 880-882. doi:10.3980/j.issn.1672-5123.2013.05.11.
[21] 龚岚, 孙兴怀, 赵耐青. 国产庆大霉素双氯芬酸钠治疗内眼术后炎症的临床疗效和安全性观察[J]. 中国眼耳鼻喉科杂志, 2006, 6(4): 223-225. doi:10.3969/j.issn.1671-2420.2006.04.007. GONG Lan, SUN Xinghuai, ZHAO Naiqing. Clinical efficacy and safety of compound gentamicin diclofenac sodium eyedrops on postoperative inflammation of phacoemulsification and trabeculectomy[J]. Chinese Journal of Ophthalmology and Otorhinolaryngology, 2006, 6(4): 223-225. doi:10.3969/j.issn.1671-2420.2006.04.007.
[22] 张青松. 高度近视眼准分子激光原位角膜磨镶术后应用双氯芬酸钠与氟米龙的疗效观察[J]. 中华眼科医学杂志(电子版), 2013, 3(4): 219-222. doi:10.3877/cma.j.issn.2095-2007.2013.04.007. ZHANG Qingsong. Obsrev ation on the clinci al effect of diclofenac sodium and fluorometholone in high myopia after LASIK[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2013, 3(4): 219-222. doi:10.3877/cma.j.issn.2095-2007.2013.04.007.
[23] 罗艳, 程旭康, 王凤娣, 等. 双氯芬酸钠滴眼液在准分子激光原位角膜磨镶术围手术期的应用[J]. 医药导报, 2013, 32(3): 334-336. doi:10.3870/yydb.2013.03.020.
[24] 万安云, 杨琳. PRK中应用双氯芬酸钠滴眼液[J]. 眼科新进展, 2001, 21(5): 358. doi:10.3969/j.issn.1003-5141.2001.05.038.
[25] 孟凡华. LASEK术后应用双氯芬酸钠滴眼液的疗效观察[J]. 中国中医眼科杂志, 2011, 21(3): 154-156. doi:10.13444/j.cnki.zgzyykzz.002818.
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