Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (2): 57-60.doi: 10.6040/j.issn.1673-3770.1.2020.012

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Efficacy of 0.1% diclofenac sodium eye drops post-SMILE

JIANG Yang, LI Ying, CUI Gen   

  1. Department of Ophthalmology, Peking Union Medical College Hospital/Chinese Academy of Medical Sciences, Beijing 100730, China
  • Published:2020-04-07

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Abstract: Objective To study the safety, efficacy, and tolerability of 0.1% diclofenac sodium eye drops after the small incision lenticule extraction(SMILE)procedure. Methods Two groups were observed, including 60 patients(60 eyes)with myopia. Thirty patients(30 eyes)were treated with topical compound tobramycin eye drops 4 times daily for 10 days as the control group. Meanwhile, 30 patients(30 eyes)were treated with topical compound tobramycin eye drops 4 times daily for 10 days, and diclofenac sodium eye drops 4 times daily for 20 days. All of the patients were observed in the preoperative and postoperative periods. The visual acuity, intraocular pressure, topography and adverse reactions were recorded at 10 d and after 1 month. The differences between the 2 groups were analyzed by the single factor analysis of variance(one-way ANOVA). Results There was no significant difference between the 2 groups in terms of uncorrected visual acuity at 10 d(P=0.12,F=2.50). However, there was after 1-month(P=0.001,F=29.78). There were no significant differences between the intraocular pressure values pre-operation, and postoperatively at 10 d and 1 month(P=0.45,0.97,0.66,F=0.56,<0.001,0.19). There were no significant differences between the 2 groups in the SRI and SAI values pre-operation and at 1 month in the SRI index(P=0.32, 0.05, 0.07,F=1.01, 3.86, 3.27). However, there was a significant difference in the SAI value 1-month post the operation (P=0.01,F=7.70). Eight patients(26.67%)in the diclofenac sodium eye drops group suffered from transient mild eye pain. However, this discomfort was relieved after a short time. Conclusion Diclofenac sodium eye drops can be an effective treatment combined with corticoids after SMILE. They are safe and were satisfactory in the recovery of visual acuity and ocular surface regularity.

Key words: Small incision lenticule extraction, Glucocorticoid, Non-steroidal, Diclofenac sodium eye drops, Uncorrected visual acuity

CLC Number: 

  • R778
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