Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (6): 108-114.doi: 10.6040/j.issn.1673-3770.0.2024.059

• Clinical Research • Previous Articles    

Analysis of reflux types in patients with laryngeal reflux associated with Helicobacter pylori infection

LIU Xiaohong, ZHANG Qingqing, GUO Ruixin, QIANG Yin, SHI Yao, YANG Haonan, CAO Nan, JIA Wei, XIE Meng   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an 710004, Shaanxi, China
  • Published:2024-12-13

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Abstract: Objective To investigate the reflux types of Laryngopharyngeal reflux(LPR)patients with Helicobacter pylori(HP)infection. Methods According to 14C breath test and 24-hour impedance pH monitoring(24 h MII-pH), all LPR patients were divided into HP(+)LPR patients(the experimental group)and HP(-)LPR patients(the control group). Both experimental and control patients underwent electronic laryngoscopy and completed reflux symptom index(RSI)and reflux finding score(RFS). The RSI and RFS scores, the number of total reflux, acid reflux and non-acid reflux and the reflux types were analyzed and compared to explore the difference between the experimental group and the control group. Results Combined with the results of 24 h MII-pH monitoring and 14C breath test, 54 patients were LPR(+), including 14 cases HP(+)(the experimental group)and 40 cases HP(-)(the control group), and the infection rate of HP was 25.93%(14/54). In the experimental group and the control group, there were no significant differences in the total score of the RSI(P=0.424>0.05)and RFS(P=0.382>0.05)scale and the incidence of symptoms and signs(P>0.05), and there were also no significant differences in the total number of reflux(P=0.470>0.05), acid reflux(P=0.207>0.05)and non-acid reflux(P=0.921>0.05)between them(P>0.05). In the experimental group, the proportion of non-acid reflux was significantly higher than that of acid reflux(57.14% vs. 14.29%,P+Non-acid=0.046),while the ratio between mixed reflux and non-acid reflux and the ratio between mixed reflux and acid reflux were both no significant different(P>0.05).In the control group the proportions of mixed reflux and non-acid reflux were significantly higher than those of acid reflux(45.00% vs. 15.00%,P-Mix=0.003;40.00% vs. 15.00%,P-Non-acid=0.012), but there was no significant difference between mixed reflux and non-acid reflux ratio(P=0.651). Conclusion Compared with the HP(-)LPR patients, the main reflux type of HP(+)LPR patients was non-acid reflux, and the symptoms and signs of cough, subglottic edema and thick endolaryngeal mucus were more obvious.

Key words: Helicobacter pylori infection, Laryngopharyngeal reflux, MII-pH monitoring, Reflux type, RSI, RFS

CLC Number: 

  • R766.5
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