Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2025, Vol. 39 ›› Issue (5): 161-168.doi: 10.6040/j.issn.1673-3770.0.2023.425

• Review • Previous Articles    

Recent advancements in the research on ferroptosis and age-related cataracts

WANG Sheng, HUANG Xudong   

  1. School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, Shandong, China
  • Published:2025-09-19

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Abstract: Ferroptosis is a form of iron-dependent cell death characterized by intracellular reactive oxygen species and lipid peroxide accumulation. In recent years, preventing the occurrence and development of related diseases by regulating cellular ferroptosis has become a focal point in pathogenic research and treatment. As the leading cause of blindness globally, cataracts, particularly age-related cataracts(ARC), can be influenced by inducers and inhibitors of ferroptosis. This suggests that ferroptosis is involved in ARC development; therefore, studying the functional changes and specific molecular mechanisms of ferroptosis in ARC has significant research value. This review discusses the latest progress in the study of ferroptosis and its findings in relation to ARC, thus providing a reference for further understanding its pathogenesis and proposing novel targets for the treatment of ARC.

Key words: Ferroptosis, Age-related cataract, Lens epithelial cells, Free radicals, Ferroptosis inhibitors, Ferroptosis inducers

CLC Number: 

  • R776.1
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