J Otolaryngol Ophthalmol Shandong Univ ›› 2013, Vol. 27 ›› Issue (4): 62-65.doi: 10.6040/j.issn.1673-3770.0.2013.209

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Correlation analysis of VEGF expression and the content of dendritic cells in nasopharyngeal carcinoma and its clinical significance

MIAO Bei-ping1，  ZHANG Rui-shi2，  GUO Zhi-hong3，  SUN Huan-ji1，  MENG Qing-guo1， WANG Xiao-bin1   

  1. 1. Department of Otolaryngology Head & Neck Surgery， Shenzhen Second People′s Hospital, First Affiliated Hospital of Shenzhen University， Shenzhen 518035, Guangdong， China； 2. Department of Ophthalmology， Shenzhen Second People′s Hospital, The First affiliated Hospital of Shenzhen University   Shenzhen 518035, Guangdong  China; 3. Shenzhen Luohu Hospital of Traditional Chinese Medicine, Shenzhen 518000, Guangdong, China
  • Received:2013-07-07 Published:2013-08-16

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Abstract:

Objective    To investigate the correlation between VEGF expression and the content of dendritic cells in nasopharyngeal carcinoma.  Methods    25 cases of nasopharyngeal carcinoma and 25 cases of nasopharyngeal lymphoid tissue were collected. The expressions of VEGF in the nasopharyngeal carcinoma and nasopharyngeal lymphoid tissues were detected by ELISA. The content of dendritic cells and regulatory T cells in the nasopharyngeal carcinoma and nasopharyngeal lymphoid tissues were detected by flow cytometry.  Then the correlation between VEGF expression and the content of dendritic cells was analyzed. Results     Expression of VEGF in nasopharyngeal carcinoma was higher than that in nasopharyngeal lymphoid tissues (t=12.324,P<0.01); the content of CD4+ lymphocyte in nasopharyngeal carcinoma was lower than that in nasopharyngeal lymphoid tissues(t=14.304, P<0.01). While the content of CD4+CD25+ regulatory T cells in nasopharyngeal carcinoma was higher than that in nasopharyngeal lymphoid tissues, and the difference was statistically significant(t=5.910, P<0.01). The content of CD123+ dendritic cells in nasopharyngeal carcinoma was lower than that in nasopharyngeal lymphoid tissues, and the difference was statistically significant(t=7.866, P<0.01). The content of CD11c+ dendritic cells in nasopharyngeal carcinoma was lower than that in nasopharyngeal lymphoid tissues, and the difference was statistically significant(t=3.411, P<0.01). The expression of VEGF was positively correlated with the content of CD4+CD25+ lymphocytes in nasopharyngeal carcinoma(r=0.966, P<0.01), and negatively correlated with the content of CD123+ dendritic cells (r= -0.946, P<0.01) and negatively correlated with the content of CD11c+ dendritic cells(r=-0.954, P<0.01). Conclusion    Expression of VEGF is related to the content of CD4+CD25+ regulatory T cells and the content of dendritic cells in nasopharyngeal carcinoma, which may engage in the immune escape of nasopharyngeal carcinoma.

Key words: Nasopharyngeal carcinoma, Dendritic cells, Regulatory T cells, Vascular endothelial growth factor

CLC Number: 

  • R739.62
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