JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

    Next Articles

Animal model of obstructive sleep apnea hypopnea syndrom with hypertension in rats

MU Chao, WANG Yan, LI Yan-zhong   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Qilu Hosptal of Shandong University, Key Laboratory of Otorhinolaryngology of Health Ministry, Jinan 250012, Shandong, China
  • Received:2014-01-15 Online:2014-04-16 Published:2014-04-16
  • Supported by:
    山东省科技攻关计划项目(2008GG10002062)

PDF (PC)

512

Abstract: Objective    To build an animal model of obstructive sleep apnea hypopnea syndrom(OSAHS)with hypertension.  Methods    10 Wistar rats which were injected 1mL Sodium Hyaluronate into the palatoglossal arch, palatopharyngeal arch and root of the tongue of served as the experimental group, and the other 10 Wistar rats as the control group. The electroencephalogram and oro-nasal airflow were recorded by PSG when rats were under anesthesia and measuring arterial systolic pressure (SBP) and OSAHS periodic. Results    ① The experimental group showed differences in apnea index (AI), the longest apnea and the lowest concentration of blood oxygen saturation before and after injection of Sodium Hyaluronate when under light anesthesia (P<0.05); ② SBP in the two groups were insignificant before building the model. The SBP of the experimental group began to rise at 4 weeks and were obvious increased when compared with the control group at 8 weeks (P<0.01). Conclusion    The animal model of OSAHS with hypertension in rats established by injection of Sodium Hyaluronate was steady and credible.

Key words: Hypertension, Wistar rats, Sleep apnea hypopnea syndrome, obstructive, Model

CLC Number: 

  • R766.7
[1] MENG Wei, YU Zhenkun, ZHENG Yali, LI Guangfei, LIANG Longjun, WANG Xiaomin. Simulation of the biomechanical effects of deaf appendage implantation in mastoid cortical bone [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 27-30.
[2] SU Jie, AI Xin, MA Chunmei, YANG Fuyu, HUANG Shuai. Relationship between acute intraocular hypertension and lateral geniculate neuron autophagy and apoptosis in rats [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 68-71.
[3] QIAO Shufen, YANG Feilun, WANG Zhenni, LI Xuezhong. Relationship between YKL-40 and chronic rhinosinusitis [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 95-99.
[4] LI Junyi, LI Xiumei, WAN Jingming, BI Jingyu, LIU Juan, XU Hualin, JIANG Yan, LI Na. Establishment of a standardized model of traumatic optic neuropathy in cats [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 43-47.
[5] HU Jindong, LIU Xinquan. Research progress of dry eye animal model. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 109-113.
[6] LI Lizhu, WU Qing, YI Xin, TIAN Li. Research progress on the animal model of allergic rhinitis in traditional Chinese medicine. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 60-63.
[7] CHEN Xuan, HAN Li, FAN Chuanfeng, LI Yingmei, LIU Jian, SHU Xiangwen, WANG Yu. Expression of endothelin-1 in plasma of patients with hypertensive retinopathy in essential hypertension. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(6): 78-80.
[8] LI Qin, CHEN Yanlin, MA Yanyi, ZHANG Yongdong. Effects of interferon gamma on Eosinophil apoptosis and Eotaxin levels in nasal lavage fluid of allergic rhinitis rats. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 30-33.
[9] ZHANG Baolin, GUO Rui, GONG Weixi, MA Jianling, LI Xianlong. Reducing the volume of soft palate and tongue with low-temperature plasma combined with pharyngeal mucosal relaxation suture in patients with obstructive sleep apnea hypopnea syndrome [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(5): 19-22.
[10] MEI Xubin, ZOU Xinbo, ZHAO Limin, LIU Wenjun. Obstructive sleep apnea syndrome combined with marfan's syndrome in 1 case [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(5): 23-24.
[11] WANG Zhiyuan, ZHANG Gehua. Establishment and application of model of chronic rhinosinusitis in mice [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(5): 76-78.
[12] WANG Honggeng, CHEN Dongsheng, LIN Qun, HUANG Fang, HONG Yuming, HUANG Jianqiang. Effects of total intravenous anesthesia on the bleed volume during endoscopic sinus surgery. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(4): 62-64.
[13] LI Danfeng, CHEN Fuquan, SHI Li, CHEN Jun. Application of stepped multi-model merged methodology in ENT clinical teaching for under-graduates. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(4): 77-79.
[14] WANG Yu-zhi, L Ling-yan, QU Zhe, WANG Xing-jie, ZHOU Xuan-yan. Changes of blood pressure in severe OSAHS patients with hypertension before and after Uvulopalatopharyngoplasty [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(5): 7-9.
[15] LI Jing-hui, WU Hong-min. Influence of nasal expansion surgery in combination with H-UPPP on blood pressure for OSAHS patients [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(4): 16-19.
Viewed
Full text
328
HTML PDF
Just accepted Online first Issue Just accepted Online first Issue
0 0 0 328 0 0

  From Others local
  Times 38 290
  Rate 12% 88%

Abstract
1211
Just accepted Online first Issue
1211 0 0
  From Others local
  Times 1208 3
  Rate 100% 0%

Cited
Web of Science  Crossref   ScienceDirect  Search for Citations in Google Scholar >>
 
This page requires you have already subscribed to WoS.
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd