舌下含服粉尘螨滴剂联合鼻用激素治疗变应性鼻炎疗效观察

doi:10.6040/j.issn.1673-3770.0.2014.227

Abstract

Abstract: Objective To evaluate the clinical efficacy of sublingual immunotherapy(SLIT) in the treatment of allergic rhinitis in combination with intranasal steroids. Methods Ninety AR patients were randomly divided into two groups: 60 patients treated by SCIT+steroids and the other 30 patients only treated with intranasal steroids. The nasal symptom scores of pruritus, sneezing, rhinorrhea and nasal obstruction were evaluated using a four-point raiting scale (from 0=absent to 3=severe) before the treatment and six months and a year after the treatment. Then the scores were compared. Results The nasal symptom scores of all patients were significantly decreased after treatment(P<0.05), and the symptoms after treatment were alleviated more significantly after one year than after 6 months in the combination group(P<0.05). However, there were no significant difference between the two periods in the single nasal spray group (P>0.05). The scores of nasal symptom in the combination group were significant lower than the single nasal spray group whether after 6 months or after 12 months. Conclusion Combination therapy of SLIT and intranasal steroids is more effective for allergic rhinitis than intranasal steroids alone.

Key words: Rhinitis, allergic, Intranasal steroids, Dust mite, Sublingual immunotherapy

CLC Number:

R765.2

XIE Xiao-hong, HU Zhi-bang, SONG Pan-pan, DAI Yan-hong, CHEN feng, YU Chen-jie, GAO Xia. Clinical efficacy of sublingual dermatophagoides farinae drops in combination with intranasal steroids in treatment of allergic rhinitis[J].JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(5): 34-37.

References

[1] Li J, Sun B, Huang Y, et al.A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J].Allergy, 2009, 64：1083-1092.
[2] 程雷,李华斌.变应性鼻炎特异性免疫治疗[J].中华耳鼻咽喉头颈外科杂志,2008,43(5)：73-76.CHENG Lei, LI Huabin. Allergic rhinitis immunotherapy[J]. Chin J Otorhinolaryngol Head Neck Surgery, 2008, 43(5):73-76.
[3] Juniper E F, Thompson A K, Ferric P J, et al.Development and validation of the mini rhinoconjunctivitis quality of life question naive[J].Chin Exp Allergy, 2000, 30(2)：132-140.
[4] 中华耳鼻咽喉头颈外科杂志编委会鼻科组,中华医学会耳鼻咽喉头颈外科学分会鼻科组. 变应性鼻炎诊断和治疗指南(2009年,武夷山) [J].中华耳鼻咽喉头颈外科杂志,2009,44(12)：977-979.Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery Subspecialty Group of Rhinology,Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association. Guide of diagnosis and treatment for allergic rhinitis(2009, Wuyishan)[J]. Chin J Otorhinolaryngol Head Neck Surgery, 2009, 44(12):977-979.
[5] 中华耳鼻咽喉头颈外科杂志编委会,中华医学会耳鼻咽喉头颈外科学分会 [J]. 变应性鼻炎的诊治原则和推荐方案(2004年,兰州), 2005, 40(3):166-168.Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Chinese Otorhinolaryngology Society of Chinese Medical Association. Treatment and diagnosis principle and the recommended scheme for allergic rhinitis(2004, Lanzhou)[J]. Chin J Otorhinolaryngol Head Neck Surgery, 2005, 40(3):166-168.
[6] Cox L.Sublingual immunotherapy in pediatric allergic rhinitis and asthma： efficacy, safety, and practical considerations[J].Curr Allergy Asthma Rep, 2007, 7(6)：410-420.
[7] 韩德民,张罗,黄丹,等.我国11个城市变应性鼻炎自报患病率调查[J].中华耳鼻咽喉头颈外科杂志,2007,42(5)：378-384. HAN Demin, ZHANG Luo, HUANG Dan, et al. An investigation of self reported prevalence of allergic rhinitis in 11 cities in China[J]. Chin J Otorhinolaryngol Head Neck Surgery, 2007, 42(5):378-384.
[8] Pajnog B, Barberio G, De Luca F, et al.Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy.A six-year follow-up study[J].Clin Exp Allergy, 2001, 31(9)：1392-1397.
[9] 程雷,李华斌.世界变态反应组织舌下免疫治疗意见书(2009)解读[J].中华耳鼻咽喉头颈外科杂志,2011,46(1)：80-83. CHENG Lei, LI Huabin. A brief introduction to World Allergy Organization position paper [J]. Chin J Otorhinolaryngol Head Neck Surgery, 2011, 46 (1):80-83.
[10] Regarding gidaro G B, Marcucci F, Sensi L, et al.The safety of sublingual-swallow immune-therapy：an analysis of published studies[J].Clin Exp Allergy,2005,35(10)：565-571.

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Clinical efficacy of sublingual dermatophagoides farinae drops in combination with intranasal steroids in treatment of allergic rhinitis

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