JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 17-20.doi: 10.6040/j.issn.1673-3770.0.2015.360

Previous Articles     Next Articles

Clinical efficacy of sublingual immunotherapy in patients with allergic rhinitis.

GU Xiao, CHEN Yanlin.   

  1. Department of Otolaryngology, Linyi Peoples Hospital, Linyi 276000, Shandong, China
  • Received:2015-08-21 Online:2016-02-16 Published:2016-02-16

PDF (PC)

643

Abstract: Objective To investigate the clinical efficacy of sublingual immunotherapy(SLIT)of standardized dermatophagoides farinae drops in patients with allergic rhinitis. Methods Totally 62 patients with moderate to severe persistent allergic rhinitis caused by dust mite received SLIT for two years. Dust mites and(or)house dust mite allergen skin prick index of all patients was ≥3+. Visual analog scale(visual analogue scale, VAS)and the maximum forced expiratory flow-volume curve(maximal expiratory flow-volume curve, MEFV)score were respectively applied to determine the nasal symptoms and small airway function before and after treatment. Results SLIT significantly reduced the individual symptoms like sneezing, rhinorrhea, nasal obstruction and pruritus after two years treatment when compared with the baseline, and the VAS scores of each symptom decreased significantly(P<0.01). The results of MEFV showed that MMEF, FEF25% and FEF50% were significantly improved after two years of SLIT treatment with significant differences(P<0.01). Conclusion SLIT of standardized dermatophagoides farinae drops has an favorite effect in patients with moderate to severe persistent allergic rhinitis.

Key words: Small airway function, Sublingual immunotherapy, Allergic rhinitis, Dermatophagoides farinae drops

CLC Number: 

  • R765.21
[1] Bousquet J, Van Cauwenberge P, Khaltav N, et al. Allergic rhinitis and its impact on asthma[J]. J Allergy Clin Immunol, 2001, 108(5 suppl):S147-334.
[2] Bousquet J, Khaltaev N, Cruz A A, et al. Allergic Rhinitis andits Impact on Asthma(ARIR)2008 update(in collaboration with the World Health Organizaion, GA2LEN and AllerGen)[J]. Allergy, 2008, 63 Suppl 86:8-160.
[3] Zuberbier T, Bachert C, Bouequet P J, et al. GA2LEN/EAACI pocket guide for allergen-specific immunotherapy for allergic rhinitis and asthma[J]. Allergy, 2010, 65(12):1525-1530.
[4] 中华耳鼻咽喉头颈外科杂志编委会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南(2009年, 武夷山)[J]. 中华耳鼻咽喉头颈外科杂志, 2009, 44(12):977-978.
[5] Bousquet P J, Combescure C, Neukirch F, et al. Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines[J]. Allergy, 2007, 62(4):376-372.
[6] Parker A L, Abu-Hijleh M, McCool F D. Ratio between forced expiratory flow between 25% and 75% of vital capacity and FVC is a determinant of airway reactivity and sensitivity to methacholine[J]. Chest, 2003, 124(1):63-69.
[7] 王成硕, 张伟, 王向东, 等. 儿童变应性鼻炎免疫治疗的临床疗效及免疫学机制研究[J]. 中华耳鼻咽喉头颈外科杂志, 2011, 46(1):36-39. WANG Chengshuo, ZHANG Wei, WANG Xiangdong, et al. Clinical efficacy and immunological changes in children with allergic rhinitis receiving specific immunotherapy with Dermatophagoides pteronyssinus[J]. Chin J Otorhinol Head Neck Surgery, 2011, 46(1):36-39.
[8] Wang H, Lin X, Hao C, et al. A double-blind, placebocontrolled study of house dust mite immunotherapy in Chinese asthmatic patients[J]. Allergy, 2006, 61(2):191-197.
[9] Zhang L, Wang C, Han D, et al. Comparative study of cluster and conventional immunotherapy schedules with dermatophagoides pteronyssinue in the treatment of persistent allergic rhinitis[J]. Int Arch Allergy Immunol, 2009, 148(2):161-169.
[10] 朱亮, 陆纪红, 谢青, 等. 皮下免疫和舌下免疫治疗粉尘螨变应性鼻炎的安全性和依从性分析[J]. 中华耳鼻咽喉头颈外科杂志, 2010, 45(6):444-449. ZHU Liang, LU Jihong, XIE Qing, et al. Compliance and safety evaluation of subcutaneous versus sublingual immunotherapy in mite sensitized patients with allergic rhinitis[J]. Chin J Otorhinol Head Neck Surgery, 2010, 45(6):444-449.
[11] Zock J P, Heinrich J, Jarvis D, et al. Distribution and determinants of house dust mite allergens in Europe:the European Community Respiratory Health Survey II[J]. J Allergy Clin Immunol, 2006, 118(3):682-690.
[12] Thomas W R, Smith W A, Hales B J, et al. Characterization and immunobiology of house duet mite allergens[J]. Int Arch Allergy Immunol, 2002, 129(1):1-18.
[13] 杨酉, 赵岩, 王成硕, 等. 变应性鼻炎患者10030例吸入性变应原谱分析 [J].中华耳鼻咽喉头颈外科杂志, 2011, 46(11):914-920. YANG You, ZHAO Yan, WANG Chengshuo, et al. Prevalence of sensitization to aeroallergens in 10030 patients with allergic rhinitis[J]. Chin J Otorhinol Head Neck Surgery, 2011, 46(11):914-920.
[14] Ciprandi G, Cirillo I. Monosensitization and polysensitization in allergic rhinitis[J]. Eur J Intern Med, 2011, 22(6):e75-79.
[15] Mete N, Sin A, Gulbahar O, et al. The determinants of bronchial hyperresponsiveness in patients with allergic rhinitis[J]. Ann Allergy Asthma Immunol, 2004, 93(2):193-199.
[16] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组、小儿学组, 中华儿科杂志编辑委员会. 儿童变应性鼻炎诊断和治疗指南(2010年, 重庆)[J]. 中华耳鼻咽喉头颈外科杂志, 2011, 46(1):7-8.
[17] Ciprandi G, Cirillo I, Tosca M A, et al. Bronchial hyperreactivity and spirometric impairment in patients with perennial allergic rhinitis[J]. Int Arch Allergy Immunol, 2004, 133(1):14-18.
[18] Bavbek S, Saryal S, Karabiyikoglu G, et al. Pulmonary function parameters in patients with allergic rhinitis[J]. J Invest Allergy Clin Immunol, 2003, 13(4):252-258.
[19] Marseglia G L, Cirillo I, Vizzaccaro A, et al. Role of forced expiratory flow at 25-75% as an early marker of small airways impairment in subjects with allergic rhinitis[J]. Allergy Asthma Proc, 2007, 28(1):74-78.
[1] WANG Tan, WU Ke, LI Lianqing, GONG Lili. Factors associated with systemic adverse reactions after subcutaneous immunotherapy injections and treatment options [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 71-74.
[2] LU Hangui, LIN Xinsheng, YAO Danmian, WEI Yongxin, LI Chuangwei. Expression of IL-35 in allergic rhinitis and its effect on the immunoregulation of T cells [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 66-70.
[3] PU Hongbo, DU Xiaodong. Allergen test results in 2 000 patients with allergic rhinitis in Wuxi District [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 105-107.
[4] CHEN Ming, YU Xuefei. Opinions on the treatment of chronic rhinosinusitis with allergic rhinitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 18-22.
[5] WU Xiangping. Influence of patient management on the clinical effect of sublingual dermatophagoides farinae drops in patients [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 68-72.
[6] LI Song, WANG Zonggui, YANG Jingpu, ZHANG Zhuping. Progress of transnasal endoscopic vidian neurectomy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(1): 72-76.
[7] ZHI Lili, SONG Daoliang. Expressions of eosinophils and IL5 in antrochoanal polyps and nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 43-46.
[8] WAN Wenjin, WANG Wen, CHENG Lei. A meta-analysis of subcutaneous immunotherapy and sublingual immunotherapy in the treatment of dust mite-allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 103-108.
[9] SHI Li, ZHAO Li, ZHANG Hongping. Long-term anti-inflammatory treatment of allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 9-12.
[10] LIU Jing. Treatment of allergic rhinitis using syndrome differentiation based on the concept of “holism” in TCM. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 28-30.
[11] CHENG Lei, QIAN Junjun, TIAN Huiqin. Research progresses on allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 1-3.
[12] XU Yu， TAO Zezhang. Pharmacotherapeutic strategies for allergic rhinitis:Ithe importance of individualization and normalization. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 4-8.
[13] LI Lizhu, WU Qing, YI Xin, TIAN Li. Research progress on the animal model of allergic rhinitis in traditional Chinese medicine. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 60-63.
[14] SHA Jichao, ZHANG Ce, ZHU Dongdong. Immunocompetence of nasal epithelial cells in allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 55-59.
[15] XIANG Nan, ZHANG Qinxiu. Experience of professor Zhang Qinxiu in the treatment of perennial allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 100-102.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd