JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2014, Vol. 28 ›› Issue (5): 38-41.doi: 10.6040/j.issn.1673-3770.0.2014.189

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Relationship between Treg cells in peripheral blood of patients with allergic rhinitis and special immunotherapy efficacy

YU Yue-jin, TAN Jun, CAO Yun-hong, ZHANG Hui, JIA Xiu-hua, YE Qing   

  1. Department of Otorhinolaryngoloy, Shanghai Seventh People's Hospital, Shanghai 200137, China
  • Received:2014-06-03 Published:2014-10-16

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Abstract: Objective To explore the expression difference of the levels of Treg cells and IL-10 of patients with allergic rhinitis (AR) in serum in different courses of special immunotherapy treatment (SIT) and to explore whether the expressions can forecast the efficacy of SIT. Methods From January 2011, 30 patients with AR were randomly collected and distributed into the 12 months SIT group and the 24 months SIT group. The peripheral blood was taken before and after the SIT, and the expressions of Treg cells were measured by FCM and IL-10 were calculated by ELISA. Results The percentage of Treg cells and the level of IL-10 in the AR groups were significantly decreased compared with those of the control group; After SIT, the percentage of Treg cells and the level of IL-10 in serum were significantly increased than those before SIT. Correlation analysis showed IL-10 was positively related with Treg cells. The clinical efficacy of the 24 months SIT group were higher than that of the 12 months SIT group, and furthermore the percentage of Treg cells and the level of IL-10 in the 24 month SIT group were significantly higher than those in the 12 month SIT group. In effective group, IL-10 level increased significantly after the SIT treatment, while the level of IL-10 did not significantly change after the treatment in non-effective group. Conclusion The percentage of Treg cells in peripheral blood of patients with AR may be useful in predicting the efficacy of the SIT treatment. A 24-month course SIT treatment is better than a 12-month course SIT treatment.

Key words: Allergic rhinitis, Special immunotherapy treatment, T regulatory cell

CLC Number: 

  • R765.21
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