JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (3): 72-75.doi: 10.6040/j.issn.1673-3770.0.2015.076

Previous Articles     Next Articles

Effect of intravitreal ranibizumab injection combined with trabelectomy and panretinal photocoagulation for neovascular glaucoma

CHAI Xuerong, ZHANG Shixi, TAO Yu, SHEN Jiaquan   

  1. Department of Ophthalmology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2015-02-04 Revised:2015-04-17 Published:2015-06-16

PDF (PC)

330

Abstract: Objective To evaluate the efficacy and safety of intravitreal ranibizumab injection combined with trabelectomy and panretinal photocoagulation (PRP) in treatment of neovascular glaucoma. Methods Twenty-four patients (24 eyes) with neovascular glaucoma who underwent intravitreal ranibizumab injection combined with trabelectomy and PRP between December 2013 and May 2014 at Shandong Provicial Hospital were observed. During a follow-up period of 8.6±1.7 months, the pre-operative and post-operative visual acuity(VA), intraocular pressure (IOP) and number of anti-glaucoma medications, also the surgical complications and success rate were observed. Results Post-operative IOP was 10.9±2.7 mmHg, 13.3±3.2 mmHg, 14.0±3.4 mmHg and 15.4±5.1 mmHg at 1 week and 1, 3 and 6 months after the surgery, which was significantly decreased compared with pre-operative one(P<0.01). The number of anti -glaucoma medications was 0.2±0.5, 0.4±0.7, 0.4±0.8 and 0.5±1.0 at 1 week and 1, 3 and 6 months after the surgery, which was significantly decreased compared with the pre-treatment one(P<0.01). At the last visit, there were 14 eyes with stable VA, 8 with VA improvement, and 2 with diminished VA. Conclusion Intravitreal ranibizumab injection combined with trabelectomy and PRP is effective and safe for neovascular glaucoma.

Key words: Neovascular glaucoma, Ranibizumab, Intravitreal injection, Trabelectomy, Panretinal photocoagulation

CLC Number: 

  • R775.3
[1] Simha A, Braganza A, Abraham L, et al. Anti-vascular endothelial growth factor for neovascular glaucoma[J].Cochrane Database Syst Rev, 2013, 10:CD007920.doi:10.1002/14651858.CD007920.pub2.
[2] Brown D M, Michels M, Kaiser P K, et al. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study[J]. Ophthalmology, 2009, 116(1):57-65.
[3] Mitchell P, Annemans L, Gallagher M, et al. Cost-effectiveness of ranibizumab in treatment of diabetic macular oedema (DME) causing visual impairment:evidence from the RESTORE trial[J]. Br J Ophthalmol, 2012, 96(5):688-693.
[4] 申家泉, 王思聪.新生血管性青光眼研究进展[J].山东大学耳鼻喉眼学报, 2011, 5(5):92-93. SHEN Jiaquan, WANG Sicong. Research on neovascular glaucoma[J]. J Otolaryngol Ophthalmol Shandong Univ, 2011, 5(5):92-93.
[5] Shen C C, Salim S, Du H, et al. Trabeculectomy versus Ahmed Glaucoma Valve implantation in neovascular glaucoma[J]. Clin Ophthalmol, 2011, 5(2):281-286.
[6] Takihara Y, Inatani M, Fukushima M, et al. Trabeculectomy with mitomycin C for neovascular glaucoma:prognostic factors for surgical failure[J]. Am J Ophthalmol, 2009, 147(5):912-918.
[7] Netland P A, Ishida K, Boyle J W. The Ahmed Glaucoma Valve in patients with and without neovascular glaucoma[J].J Glaucoma, 2010, 19(9):581-586.
[8] Frezzotti P, Mittica V, Martone G, et al. Long term follow-up of diode laser transscleral cyclophotocoagulation in the treatment of refractory glaucoma[J].Acta Ophthalmol, 2010, 88(1):150-155.
[9] Izgi B, Demirci H, Demirci F Y, et al. Diode laser cyclophotocoagulation in refractory glaucoma: comparison between pediatric and adult glaucomas[J]. Ophthalmic Surg Lasers, 2000, 32(2):100-107.
[10] Schlote T, Derse M, Rassmann K, et al.Efficacy and safety of contact transscleral diode laser cyclophotocoagulation for advanced glaucoma[J].J Glaucoma, 2001, 10(4):294-301.
[11] Alkawas A A, Shahien E A, Hussein A M. Management of neovascular glaucoma with panretinal photocoagulation, intravitreal bevacizumab, and subsequent trabeculectomy with mitomycin C[J].J Glaucoma, 2010, 19(9):622-626.
[12] Saito Y, Higashide T, Takeda H, et al. Beneficial effects of preoperative intravitreal bevacizumab on trabeculectomy outcomes in neovascular glaucoma[J]. Acta Ophthalmologica, 2010, 88(1):96-102.
[13] CATT Research Group, Martin D F, Maguire M G, et al. Ranibizumab and bevacizumab for neovascular age-related macular degeneration[J]. N Engl J Med, 2011, 364(20):1897-1908.
[14] 王丽丽, 李立婕, 郑波, 等. Becacizumab联合格栅样光凝治疗CRVO黄斑水肿的临床观察[J]. 国际眼科杂志, 2011, 11(10):1769-1771. WANG Lili, LI Lijie, ZHENG Bo, et al. Clinical observation of Becacizumab combined with grid photocoagulation for the treatment of cystoid macular edema associated with central retinal vein occlusion[J].Inter J Ophthalmol, 2011, 11(10):1769-1771.
[15] Canut M I, Alvarez A, Nadal J, et al. Anterior segment changes following intravitreal bevacizumab injection for treatment of neovascular glaucoma[J]. Clin Ophthalmol, 2011, 5:715.
[16] Zhang H T, Yang Y X, Xu Y Y, et al. Intravitreal bevacizumab and Ahmed glaucoma valve implantation in patients with neovascular glaucoma[J].Inter J Ophthalmol, 2014, 7(5):837-842.
[17] Miki A, Oshima Y, Otori Y, et al. One-year results of intravitreal bevacizumab as an adjunct to trabeculectomy for neovascular glaucoma in eyes with previous vitrectomy[J].Eye, 2011, 25(5):658-659.
[1] ZHOU Xueyi, LI Yiming, WANG Meiju, ZHANG Yuanyuan, ZHANG Lizhuo. The application of 25-gauge minimally invasive vitreoretinal surgery combined with intravitreal ranibizumab injections in the treatment of proliferative diabetic retinopathy. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 87-89.
[2] . Clinical observation on the treatment of CSME and NCSME by intravitreal injection of ranibizumab. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(2): 96-98.
[3] . Clinical observation on the treatment of BRVO-ME by the combination of laser therapy with Ranibizumab intravitreal injection. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(1): 110-113.
[4] YAN Xiaoteng, FENG Jun, KANG Xinle. Intravitreal injection of conbercept for macular edema secondary to retinal vein occlusion. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 105-108.
[5] ZHAO Lu, XIE Guoli, WANG Yanling. Changes of ocular hemodynamics after intravitreal ranibizumab injection in patients with wet age-related macular degeneration. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(4): 101-104.
[6] ZI Yu-meng1, WANG Yu2, FAN Chuan-feng2, SHU Xiang-wen2, WU Chang-long2. Intravitreal injection of Ranibizumab for idiopathic choroidal neovascularization lesion in two courses [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(3): 63-66.
[7] ZHANG Yi-xia, YANG Wei, QIU Ming-lei, CHEN Ning-ning. Earlier panretinal photocoagulation for heavy typeⅡoptic disc vasculitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(4): 66-68.
[8] NIE Qiao-li1,2，TAO Yuan2，WU Xin-yi1， GUO Bai-ling 2. Comparison between combined therapy of trabeculectomy with cyclocryotherapy and single therapy of cyclocryotherapy for neovascular glaucoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(4): 58-61.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd