JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (3): 77-81.doi: 10.6040/j.issn.1673-3770.0.2016.065

Previous Articles     Next Articles

IgG4-related disease:four cases report and a literature review.

LIU Yue, ZHAO Xue, LIU Yan, JIN Chengxun, WEI Ning, JIN Chunshun, WANG Sanchun   

  1. Department of Otorhinolaryngology &Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130000, Jilin, China
  • Received:2016-02-22 Online:2016-06-16 Published:2016-06-16

PDF (PC)

1137

Abstract: Objective To explore the clinical features, pathological features and imaging manifestations of IgG4-related disease. Methods The clinical data of four cases of IgG4-related disease were analyzed and the related literatures were summarized. Results The average age was 55 years old. The proportion of male: female was 3∶1. 2 cases occurred in the submandibular gland, 1 in the eye socket and 1 in the facial region. There were no significant specificity, and the clinical manifestations were painless progressive swelling. Pathologic changes were lymphoid tissue and fibrous tissue hyperplasia, which had more plasma cell infiltration(IgG4 positive plasma cells more than 50/HPF, IgG4 positive plasma cells were greater than 40% IgG positive plasma cells). Inflammatory changes were lesions on imaging area. Conclusion IgG4 related disease is a rarely clinical disease, pathogenesis is unclear. Combined with clinical manifestations, serological detection, pathological features and imaging findings, diagnosis results are obtained, and timely accurate treatment can be carried out.

Key words: IgG4-related disease, Submadibular gland, Lacrimal gland, Diagnosis

CLC Number: 

  • R365
[1] Ferry J A, Deshpande V. IgG4-related disease in the head and neck[J]. Semin Diagn Pathol, 2012, 29(4):235-244.
[2] Geyer J T. Ferry J A, Harris N L, et al. Chronic sclerosing sialadenitis(Kuttner tumor)is an IgG4-associated disease[J]. Am J Surg Pathol, 2010, 34(2):202-10. doi: 10.1097/PAS.0b013e3181c811ad.
[3] Himi T, Takano K, Yamamoto M, et al. A novel concept of Mikuliczs disease as IgG4-related disease[J]. Auris Nasus Larynx, 2012, 39(1):9-17.
[4] Hamano H, Kawa S, Horiuchi A, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis[J]. N Engl J Med, 2001, 344(10):732-738.
[5] Kamisawa T, Funata N, Hayashi Y, et al. A new clinicopathological entity of IgG4-related autoimmune disease[J]. Gastroenterol, 2003, 38(10):982-984.
[6] Zen Y, Nakanum Y. IgG4-related disease: a cross-sectional study of 114 cases[J]. Am J Surg Pathol, 2010, 34(12):1812-1819. doi: 10.1097/PAS.0b013e3181f7266b.
[7] Nishimori I, Tamakoshi A, Otsuki M, et al. Prevalence of autoimmune pancreatitis in Japan from a nationwide survey in 2002[J]. J Gastrosnterol, 2007, 42(Suppl 18):6-8.
[8] 苏玉莹,王晨琼,董凌莉.IgG4相关性疾病的发病机制及进展[J].中华临床医师杂志,2014,8(14):2713-2717. SU Yuying, WANG Chenqiong, DONG Lingli. Progress in pathogenesis of IgG4-related disease[J]. Chin J Clinicians(Electronic Edition), 2014, 8(14):2713-2717.
[9] 高海燕,彭诗东,韩德民,等.慢性鼻窦炎患者血清IgG4测定的临床意义[J].中国耳鼻咽喉颅底外科杂志,2000, 6(2):117-119.
[10] 余长亮,刘斌,余永强.头颈部IgG4相关性疾病的临床及影像学诊断[J].国际医学放射学杂志,2013,36(2):118-121. YU Changliang, LIU Bin, YU Yongqiang. Clinical and imaging diagnosis of IgG4-related disease in the head and neck[J]. Inter J Med Radiol, 2013, 36(2):118-121.
[11] Sato Y, Ohshima K, Ichimura K, et al. Ocular adnexal IgG4-related disease has uniform clinicopathology[J]. Pathol Int, 2008, 58(8):465-470. doi: 10.1111/j.1440-1827.2008.02257.x
[12] Okazaki K, Uchida K, Koyabu M, et al. Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease[J]. J Gastroenterol, 2011, 46(3):277-288.
[13] Carruthers M N, Khosroshahi A, Augustin T, et al. The diagnostic utility of serum IgG4 concentrations in IgG4-related disease[J]. Ann Rheum Dis, 2014, 74(1):14-18.
[14] Kamisawa T, Takuma K, Egawa N, et al. Autoimmune ne pancreatitis and IgGd.related sclerosing disease[J]. Nat Rev Gastroenterol Hepatol, 2010, 7(7):401-409.
[15] Wallace Z S, Khosroshahi A, Jakobiec F A, et al. IgG4-related systemic disease as a cause of”idiopathic”orbital inflammation including orbital myositis and trigeminal nerve involvement[J]. Surv Ophthalmol, 2012, 7(1):26-33.
[16] Takahira M, Kawano M, Zen Y, et al.IgG4-related chronic sclerosing dacryoadenitis[J]. Arch Ophthalmol, 2007, 125(11):1575-1578.
[17] Kamisawa T, Okazaki K, Kawa S, et al.Japanese consensus guidelinesfor management of autoimmune pancreatitis: III.Treatment and prognosis of AIP[J]. J Gastroenterol, 2010, 45(5):471-477.
[18] Pannala R, Chari S T. Corticosteroid treatment for autoimmune pancreatitis[J]. Gut, 2009, 58(11):1438-9. doi: 10.1136/gut.2009.183293.
[19] Khosroshahi A, Carruthers M, Deshpande V, et al. Rituximab for the treatment of IgG4-related disease: lessons from ten consecutive patients[J]. Medicine, 2012, 91(1):57-66.
[1] CHENG Zhuo, LIANG Hui, XING Lumin. Research progress and prospect analysis of deep learning technology in the application of pharyngeal and laryngeal endoscopy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 112-119.
[2] LIU Yijie, LU Xiuzhen, WU Qiuxin. Research rogress of exosomes in the pathogenesis, diagnosis and treatment in ophthalmic diseases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 135-141.
[3] LI Zan, LU Qi, SHEN Weidong, HOU Zhaohui, WU Nan. Clinical diagnosis and treatment features of 18 cases of necrotizing otitis externa [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 17-22.
[4] MA Xiaobao, SHEN Jiali, YANG Jun, CHEN Jianyong, ZHU Songhuan. Exploring the clinical implications of normal VOR gain with refixation saccades in lateral canal [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 40-45.
[5] LIU Ziqi, HUANG Jiali, WANG Liqin, CHEN Xi, ZHANG Liqing, ZHOU Han. Application of narrow band imaging endoscopy combined with voice acoustic analysis in the differential diagnosis of vocal cord leukoplakia [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 87-96.
[6] SUN Shuo, YUAN Tiejun, CHEN Yao, QI Lingling, HAN Rongrong. Misdiagnosis of lingual tuberculosis: a case report and literature veview [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 138-143.
[7] LIU Nanxian, YANG Zeyin, HAN Lin, ZHANG Aiying, ZHAO Yuliang, XUE Jing, SUN Yijun, SHAO Yongliang. Significance of video-EEG in the diagnosis of recurrent vertigo in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 20-25.
[8] ZHOU Zhihang, LIU Suru, ZHOU Jing, CHEN Dan, YANG Jiajing, LIU Rui, ZHOU Li. Etiology and treatment advances in glottic insufficiency [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 97-103.
[9] WU Wei, WANG Lei, CHEN Sheng, LI Lianyong, WANG Gang. Multidisciplinary research and advances in gastro-oesophageal reflux disease [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6): 1-14.
[10] LIU Lianlian, LI Jinrang. Obstructive sleep apnea and laryngopharyngeal reflux [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6): 15-22.
[11] LI Gui, YANG Yanli, LI Donghai, YAN Xiuying. Adult orbital xanthogranulomatous disease with clinicopathological analysis report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 80-85.
[12] PENG Yuting, LI Jianhao, WANG Yan. Orbital apex syndrome secondary to nasal-orbital-skull base malignant tumor: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 105-111.
[13] CHEN Haiyan, WANG Ping. Easily misdiagnosed posterior scleritis:a case and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 126-130.
[14] ZHANG Yuhuan, ZHANG Junbo, YIN Guoping, YUAN Xuemei, CAO Xin, SUN Yu, CHEN Qiang, YE Jingying. Comparative analysis of polysomnography parameters between the first and second halves of the night in snoring patients [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 112-117.
[15] XU Cong, LU Guowei, LÜ Yongbin, LIU Dawei, SONG Xicheng, SUN Yan. Intracranial pneumatosis caused by peritonsillar abscess incisional drainage: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 63-67.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd