Abstract: Objective To explore the efficacy and associated factors of endoscopic sinus surgery on patients with chronic rhinosinusitis(CRS)with or without nasal polyps. Method A total of 126 CRS patients with nasal polyps and 154 without nasal polyps were included and treated by endoscopic sinus surgery, then were follow up for 6 months. The efficacy, complications and quality of life were compared between the two groups, and the factors of efficacy were analyzed. Results There was no significant difference in efficacy and complication rate between the two groups(P>0.05); after treatment, physical health, physical role functioning, mental health, emotional role function, energy, and general health in quality of life questionnaire SF-36 were increased(P<0.05), emotional role function was significantly higher in patients with CRS without nasal polyps than that in patients with nasal polyps(t=-4.107, P<0.001); after treatment, the law of nasal irrigation(P<0.001, OR=0.456, 95%CI: 0.727-0.913)and the regular use of hormones(P=0.029, OR=0.645, 95%CI: 0.325-0.752)had a significant impact on the outcome. Conclusion There is no difference in efficacy and safety for endoscopic sinus surgery between the patients with CRS with and without nasal polyps, but without nasal polyps patients recover better emotional role function, the efficacy of CRS is also subject to the law whether postoperative nasal irrigation and row hormones, and therefore should pay attention to the postoperative clinical treatment.

Key words: Nasal polyps, Efficacy, Factor, Quality of life, Chronic rhinosinusitis