JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (6): 81-84.doi: 10.6040/j.issn.1673-3770.0.2015.358

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Research progress of Fascin-2 gene function.

YANG Linlin1,2, SONG Xicheng2, HAN Fengchan1   

  1. 1. Key Laboratory for Genetic Hearing Disorders in Shandong, Binzhou Medical University, Yantai 264003, Shandong, China;2. Department of Otolaryngology &Head and Neck Surgery, Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai 264000, Shandong, China
  • Received:2015-08-22 Online:2016-12-16 Published:2016-12-16

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Abstract: Fascin-2 gene, an actin cross-linking protein found in membrane ruffles, microspikes, and stress fibers, controls the parallel, sequential, and tight alignment and aggregation of actin filaments. Recent researches have found that Fascin-2 gene is associated with the cilia of plasma membrane, whose basic composition is actin; Fascin-2 gene plays an important role in the formation of photoreceptor disk and stereocilia; the mutation of Fascin-2 gene may cause progressive retinitis pigmentosa and hearing loss. This paper will elucidate the latest research progress on Fascin-2 gene.

Key words: Hearing loss, Retinitis pigmentosa, Fascin-2

CLC Number: 

  • R764.4
[1] Bryan J, Kane R E. Separation and interaction of the major components of sea urchin actin gel[J]. J Mol Biol, 1978, 125(2):207-224.
[2] Kureishy N, Sapountzi V, Prags A, et al. Fascins,and their roles in cell structure and function[J]. Bioessays, 2002, 24(4):350-361.
[3] Hashimoto Y, Parsons M, Adams J C. Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of rac and contribute to metastasis[J]. Mol Biol Cell, 2007, 18(11):4591-4602.
[4] Vignjevic D, Kojima S, Aratyn Y, et al. Role of fascin in filopodial protrusion[J]. J Cell Biol, 2006, 174(6):863-875.
[5] Li A, Dawson J C, Forero-Vargas M, et al. The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion[J]. Curr Biol, 2010, 20(4):339-345.
[6] Chou S W, Hwang P, Gomez G, et al. Fascin 2b is a component of stereocilia that lengthens actin-based protrusions[J]. PLoS One, 2011, 6(4):e14807.
[7] Shin J B, Longo-Guess C M, Gagnon L H, et al. The R109H variant of Fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice[J]. J Neurosci, 2010, 30(29):9683-9694.
[8] Perrin B J, Strandjord D M, Narayanan P, et al. β-Actin and Fascin-2 cooperate to maintain stereocilia length[J]. J Neurosci, 2013, 33(19):8114-8121.
[9] Ziviello C, Simonelli F, Testa F, et al. Molecular genetics of autosomal dominant retinitis pigmentosa( ADRP): a comprehensive study of 43 Italian families[J]. J Med Genet, 2005, 42(7):e47.
[10] Lin C T, Gould D J, Petersen-Jones S M, et al. Canine inherited retinal degenerations: update on molecular genetics research and its clinical application[J]. J Small Anim Pract, 2002, 43(10):426-432.
[11] Wada Y, Abe T, Takeshita T, et al. Mutation of human retinal fascin gene(Fscn2)causes autosomal dominant retinitis pigmentosa[J]. Invest Ophthalmol Vis Sci, 2001, 42(10):2395-2400.
[12] Wada Y, Abe T, Itabashi T, et al. Autosomal dominant macular degeneration associated with 208delG in FSCN2 gene[J]. Arch Ophthalmol, 2003, 121(11):1613-1620.
[13] Yokokura S, Wada Y, Nakai S, et al. Targeted disruption of FSCN2 Gene induces retinopathy in mice[J]. Invest Ophthalmol Vis Sci, 2005, 46(8):2905-2915.
[14] Soundararajan R, Won J, Stearns T M,et al. Gene profiling of postnatal Mfrprd6 mutant eyes reveals differential accumulation of Prss56, visual cycle and phototransduction mRNAs[J]. PLoS One, 2014, 9(10):e110299.
[15] Morton C C, Nance W E. Newborn hearing screening-a silent revolution[J]. N Engl J Med, 2006, 354(20):2151-2164.
[16] Avenarius M R, Saylor K W, Lundeberg M R, et al. Correlation of actin crosslinker and capper expression levels with stereocilia growth phases[J]. Mol Cell Proteomics, 2014, 13(2):606-620.
[17] Tilney L G, DeRosier D J. Actin filaments,stereocilia,and hair cells of the bird cochlea. IV. How the actin filaments become organized in developing stereolilia and in the cuticular plate[J]. Dev Biol, 1986, 116(1):119-129.
[18] Loomis P A, Zheng L, Sekerkova G, et al. Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo[J]. J Cell Biol, 2003, 163(5):1045-1055.
[19] Zhang D S, Piazza V, Perrin B J, et al. Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia[J]. Nature, 2012, 481(7382):520-524.
[20] Kazmierczak P, Sakaguchi H, Tokita J, et al.Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells[J]. Nature, 2007, 499(7158):87-91.
[21] Caberlotto E, Michel V, Foucher I, et al. Usher type 1G-protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia[J]. Proc Natl Acad Sci USA, 2011, 108(14):5825-5830.
[22] Noben-Trauth K, Zheng Q Y, Johnson K R. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss[J]. Nat Genet, 2003, 35(1):21-23.
[23] Nagtegaal A P, Spijker S, Crins T T, et al. A novel QTL underlying early-onset,low-frequency hearing loss in BXD recombinant inbred strains[J]. Genes Brain Behav, 2012, 11(8):911-920.
[24] Hashimoto Y, Kim D J, Adams J C. The roles of fascins in health and disease[J]. J Pathol, 2011, 224(3):289-300.
[25] Suzuki S, Ishikawa M, Ueda T, et al. Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice[J]. Exp Anim, 2015, 64(3):241-251.
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