JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2018, Vol. 32 ›› Issue (3): 42-46.doi: 10.6040/j.issn.1673-3770.0.2017.522

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The expression and significance of p-ERK2/ ERK2 in nasal polyps

LI Hongmei1, WANG Lan1, GAO Zhaohui2, WANG Ying3, XUE Jinmei2   

  1. Department of Otolaryngology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China;3.Department of Pathology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, China
  • Received:2017-12-14 Online:2018-05-20 Published:2018-05-20

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Abstract: Objective To detect the expression of p-ERK2/ ERK2 in nasal polyps(NPs)and to explore the clinical significance of p-ERK2/ ERK2 in the pathogenesis of NPs. Methods Indirect immunofluorescence and western blotting were used to detect the expression of p-ERK2/ ERK2 in NPs and normal nasal mucosa. Results In the NP group, p-ERK2 was primarily expressed in the proliferative epithelial cells, inflammatory cells, and glandular epithelial cells, and was localized predominantly in the nucleus; ERK2 was mainly expressed in the glandular epithelial cells and inflammatory cells, and was localized predominantly in the cytoplasm. In the normal nasal mucosa group, p-ERK2 was primarily expressed in the inflammatory cells and glandular epithelial cells, and was localized predominantly in the nucleus; ERK2 was mainly expressed in the inflammatory cells, and was localized predominantly in the cytoplasm. Considering fluorescence intensity as an index for expression, p-ERK2 expression showed a significant difference between the NP and normal nasal mucosa groups(P<0.05), while ERK2 expression did not(P>0.05). Using the gray values from Western blotting, p-ERK2 expression showed a significant difference between the two groups(P<0.05), while ERK2 expression did not(P>0.05). Conclusion p-ERK2 might play an important role in the pathogenesis of nasal polyps. However, ERK2 might not be involved in the initiation of nasal polyps; ERK2 was not only expressed in nasal polyps, but also in the normal nasal mucosa, suggesting that ERK2 might be involved in the maintenance of the normal physiological function of the nasal mucosa.

Key words: Sinusitis, ERK signal pathway, p-ERK2, ERK2, Nasal polyps

CLC Number: 

  • R765.2
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