Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2018, Vol. 32 ›› Issue (6): 92-97.doi: 10.6040/j.issn.1673-3770.0.2018.272

Previous Articles     Next Articles

Clinical study of compaq combined with laser in the treatment of retinopathy of prematurity

GUO Bao, ZHANG Deyong   

  1. Department of Ophthalmology, Xuzhou Childrens Hospital, Xuzhou 221006, Jiangsu, China
  • Published:2018-11-29

PDF (PC)

457

Abstract: Objective To observe the clinical effect of treatment with Compaq, laser, and a combination for the treatment of retinopathy of prematurity(ROP). Methods Sixty-three children(126 eyes)with ROP treated in our hospital from February 2016 to December 2017 were randomly divided into three groups of 21 patients(42 eyes)using the envelope method. Laser photocoagulation treatment group was treated with laser photocoagulation alone, compaq treatment group was treated with compaitcept glass cavity injection alone, and combined treatment group was treated with compaitcept glass body cavity injection and laser irradiation combined with laser photocoagulation. The clinical effects observed in the three groups were compared, and the indices related to the retinal electroretinogram and changes in the equivalent spherical mirror and astigmatism were analyzed. Complications and follow-up results were analyzed during and after treatment. Results The rate of controlled disease in laser photocoagulation treatment group, compaq treatment group and combined treatment group was 71.43%, 66.67% and 95.24%(H=5.694, P=0.058). Regarding the amplitude of the flash electroretinogram(F-ERG)reaction, the amplitude of the b-wave, the cone-rod mixed maximum response a- and b-waves, there was significant difference between the above three groups(all P<0.05). Regarding the F-ERG response latency, peak mixed rod-cone response a- and b-wave, there was significant difference between the above three groups(all P<0.05). Regarding myopia, high myopia, astigmatism, and high astigmatism, there was significant difference between the above three groups(all P<0.05). The incidence of complications was 23.80%, 19.04% and 14.28%(χ2=0.618, P=0.432)in laser photocoagulation treatment group, compaq treatment group and combined treatment group. During the follow-up period, the recurrence rate of ROP in laser photocoagulation treatment group, compaq treatment group and combined treatment group was 33.33%、28.57% and 4.76%. The recurrence rate of ROP in laser photocoagulation treatment group and compaq treatment group significantly higher than that in combined treatment group(all P<0.05). Conclusion Treatment with Compaq combined with laser is effective and safe for the treatment of ROP.

Key words: Compaq, laser, Rapid advance, Premature, Retinopathy of prematurity

CLC Number: 

  • R779.7
[1] Fang JL, Sorita A, Carey WA, et al. Interventions to prevent retinopathy of prematurity: a meta-analysis[J]. Pediatrics, 2016, 137(4):1-17.
[2] Yum SK, Moon CJ, Youn YA, et al. Expanded criteria for retinopathy of prematurity screening in moderately preterm infants: Single-center pilot study[J]. Ped Inter, 2016, 58(11):1158-1162.
[3] Lok JYC, Yip WWK, Luk ASW, et al. Visual outcome and refractive status in first 3 years of age in preterm infants suffered from laser-treated Type 1 retinopathy of prematurity(ROP): a 6-year retrospective review in a tertiary centre in Hong Kong[J]. Inter Ophthalmol, 2018, 38(1):163-169.
[4] 程湧, 梁建宏, 黎晓新. 康柏西普玻璃体腔注射治疗急进性后极部早产儿视网膜病变的疗效观察[J]. 中华眼底病杂志, 2017, 33(2):144-147. CHENG Yong, LIANG Jianhong, LI Xiaoxin, et al. Intravitreal injection of conbercept for aggressive posterior retinopathy of prematurity[J]. Chin J Ocular Fundus Dis, 2017, 33(2):144-147.
[5] 中华医学会眼科学分会眼底病学组. 中国早产儿视网膜病变筛查指南(2014年)[J]. 中华眼科杂志, 2014, 50(12):933-935.
[6] Visser L, Singh R, Young M, et al. Guideline for the prevention, screening and treatment of retinopathy of prematurity(ROP)[J]. S Afr Med J, 2012, 103(2):116-125.
[7] 刘海洋, 李盨雁, 张正培,等. 改良膜分割与双手膜清除技术在23 G玻璃体手术治疗增殖性糖尿病视网膜病变中的对比[J].山东大学耳鼻喉眼学报, 2015, 29(1):52-55. LIU Haiyang, LI Suyan, ZHANG Zhengpei, et al. Comparison of improved membrane dissection and bimanual enbloc excision in 23 G vitrectomy to treat prolifera-tive diabetic retinopathy[J]. J Otolaryngol Ophthalmol Shandong Univ, 2015, 29(1):52-55.
[8] 周学义, 李一鸣, 王美菊,等. 25+微创玻璃体视网膜手术联合玻璃体腔注射雷珠单抗治疗增生型糖尿病视网膜病变的临床观察[J]. 山东大学耳鼻喉眼学报, 2017, 31(4):87-89. ZHOU Xueyi, LI Yiming, WANG Meiju, et al. The application of 25-gauge minimally invasive vitreoretinal surgery combined with intravitreal ranibizumab in jections in the treatment of proliferative diabetic retinopathy[J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(4):87-89.
[9] Kabata EU, Kurtul BE, Özer P A, et al. Comparison of intravitreal bevacizumab, intravitreal ranibizumab and laser photocoagulation for treatment of type 1 retinopathy of prematurity in turkish preterm children[J]. Curr Eye Res, 2017, 42(7):1054-1058.
[10] Hondur AM, Çubuk MÖ, Özen Tunay Z, et al. Intravitreal bevacizumab for retinopathy of prematurity in infants ineligible for laser therapy[J]. Turk J Med Sci, 2016, 46(3):764-768.
[11] 焦明菲, 李筱荣. 康柏西普玻璃体腔注射治疗高度近视脉络膜新生血管的临床疗效及安全性分析[J]. 中华实验眼科杂志, 2016, 34(8):725-728. JIAO Mingfei, LI Xiaorong. Clinical safety and efficacy of conbercept intravitreal injection on high myopic choroidal neovascularization[J]. Chin J Exp Ophthalmol, 2016, 34(8):725-728.
[12] 刘三梅, 李杰, 董文韬,等. 玻璃体腔内注射康柏西普联合视网膜光凝治疗增生性糖尿病视网膜病变的中长期临床观察[J]. 成都中医药大学学报, 2017, 40(1):63-65. LIU Sanmei, LI Jie, DONG Wentao, et al. Long-term clinical observation of intravitreal injection of conbercept combined with pan retinal photocoagulation in the treatment of patients with proliferative diabetic retinopathy[J]. J Chengdu Univ Trad Chin Med, 2017, 40(1):63-65.
[13] 姚昱欧, 尹虹, 黎晓新,等. 激光光凝治疗对早产儿视网膜病变视野及屈光状态的影响[J]. 中华眼底病杂志, 2017, 33(2):148-152. YAO Yuou, YIN Hong, LI Xiaoxin Zhao, et al. Visual field outcomes and refractive status of retinopathy of prematurity after laser treatment[J]. Chin J Ocular Fundus Dis, 2017, 33(2):148-152.
[14] 罗毅, 王平. 早产儿视网膜病变的神经视网膜发育研究[J]. 国际眼科杂志, 2015, 15(10):1741-1744. LUO Yi, WANG Ping. Development of neural retina in retinopathy of prematurity[J]. Inter Eye Sci, 2015, 15(10):1741-1744.
[15] 黄江, 易全勇, 季晓燕,等. 急性中心性浆液性脉络膜视网膜病变激光治疗前后渗漏灶视网膜色素上皮形态变化观察[J]. 中华眼底病杂志, 2016, 32(3):266-269. HUANG Jiang, YI Quanyong, JI Xiaoyan, et al. Morphologic features of retina pigment epithelial around fluorescein leakage sites in acute central serous chorioretinopathy before and after laser coagulation[J]. Chin J Ocular Fundus Dis, 2016, 32(3):266-269.
[16] 韩林峰, 柯根杰, 王林,等.全视网膜激光光凝对增生型糖尿病视网膜病变视网膜前膜中环氧化酶-2、血管内皮生长因子表达的影响[J]. 中华眼底病杂志, 2016, 32(2):140-143. HAN Linfeng, KE Genjie, WANG Lin, et al. Effect of panretinal photocoagulation on the expression of cyclooxygenase-2, vascular endothelial cell growth factor in epiretinal membrane of proliferative diabetic retinopathy[J]. Chin J Ocular Fundus Dis, 2016, 32(2):140-143.
[17] 田汝银, 张国明, 程璐璐,等. 早产儿视网膜病变激光术后嵴前无血管区的临床观察[J]. 国际眼科杂志, 2017, 17(4):778-780. TIAN Ruyin, ZHANG Guoming, CHENG Lulu, et al. Clinical outcome of nonvascularization area after laser photocoagulation in patients with retinopathy of prematurity[J]. Inter Eye Sci, 2017, 17(4):778-780.
[18] 赵旭丽, 张娣, 阳光,等. 术前玻璃体腔注射康柏西普对严重增生型糖尿病视网膜病变手术的影响[J]. 中国眼耳鼻喉科杂志, 2018, 18(1):22-25. ZHAO Xuli, ZHANG Di, YANG Guang, et al. Intravitreal conbercept as a pretreatment of vitrectomy for patients with severe proliferative diabetic retinopathy[J]. Chin J Ophthalmol Otorhinolaryngol, 2018, 18(1):22-25.
[19] 张艳, 柴剑. 激光联合康柏西普治疗对糖尿病性视网膜病变患者血清细胞因子及氧化产物的影响[J]. 海南医学院学报, 2017, 23(11):1586-1588. ZHANG Yan, CHAI Jian. Influence of Laser combined with Conbercept on serum cytokines and oxidation products in diabetic retinopathy patients[J]. J Hainan Med Univ, 2017, 23(11):1586-1588.
[1] SONG Yanling, SI Yuanyuan, CUI Yan. Minimal quantity vitrectomy for laser-pointer induced full-thickness macular hole in a child: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 144-147.
[2] CHEN Tao, JIANG Yang, LI Ying. SMILE correction of refractive regression after PRK surgery: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 148-153.
[3] ZHANG Guoming, WEI Wenbin, LIN Haotian, CHI Wei, ZHANG Shaochong, ZHAO Peiquan, LEI Baiying, CHEN Youxin, WANG Yusheng, HE Mingguang, LIANG Jianhong, LU Hai, LU Fang, HUANG Xin, LIANG Xiaoling, ZHAO Xinyu, WU Zhenquan, YU Zhen, CUI Kaixuan, LIU Yaling, XIANG Daoman, CHEN Changzheng, ZHANG Zifeng, LIN Duoru, YU Shanshan, SUN Yue, TAN Tao, CHEN Yanxian, PENG Jie, DONG Li, CHENG Yong, ZHU Xuemei, YANG Peng, CHEN Shaobin. Expert consensus on AI-assisted diagnosis and treatment of retinopathy of prematurity(2025) [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 1-5.
[4] WANG Tan, WANG Jing, LI Yanzi, BU Lingnan, YANG Sujuan. Hypopharyngeal fibrovascular polyp:a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 121-125.
[5] XIAO Zhe, ZHANG Shengjuan, ZHAO Ziqi, XING Chen, LI Chengquan, LIU Zhiqiang. Ultra Q:YAG laser treatment for macular retinal pre-retinal hemorrhage in 17 cases and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 130-135.
[6] HU Yarou, ZHAO Xinyu, WU Zhenquan, FAN Zixin, YU Zhen, LIU Yaling, CHEN Tingyi, ZENG Jian, ZHANG Guoming. Research progress on refractive status and ocular biometrics in preterm births [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 144-150.
[7] ZHOU Jinglin, LI Jinxiang, ZENG Qi. Effect of 577 nm subthreshold micropulse laser photocoagulation combined with anti-VEGF on the treatment of refractory diabetic macular edema [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(2): 18-25.
[8] TANG Huixin, LI Jingjing, ZOU Hong. Mechanism and clinical applications of subthreshold diode micropulse laser [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 143-148.
[9] DU Yueshanyi, WANG Xian, ZHANG Guoming. Progress in the diagnosis and treatment of retinopathy of prematurity using artificial intelligence [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(3): 157-162.
[10] DONG Shuguang, GUO Fengfei, MENG Xuxia, YAN Shilong. Retrospective analysis of the causes of anterior capsular tear in early femtosecond laser-assisted cataract surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(1): 110-114.
[11] HU Zunxia, SIMA Jing, QIN Bo, CAO Jiaguo, PAN Wei. Comparative study on the use of contact lens in Nd: YAG laser posterior capsulotomy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(5): 41-45.
[12] LI Lijie, TIAN Xiufen. Forty cases of early glottic cancer treated by CO2 laser surgery combined with radiofrequency ablation [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 79-85.
[13] LONG Ting, LIU Yuwei, WANG Shengcai, ZHANG Jie, LI Yanzhen, ZHANG Xuexi, LIU Qiaoyin, LIU Zhiyong, SUN Nian, NI Xin. A clinical analysis on children with congenital pyriform sinus fistula treated through microscopic laryngoscopy with CO2 laser cauterization [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 125-130.
[14] CHEN Tao, LI Yaoyu, YANG Majun, YAN Hongxin, LIU Guangyi, ZHAI Changbin. Active suction loss to treat complications of small-incision lenticule extraction [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 20-24.
[15] ZHANG Ying, LEI Yulin, MA Zhixing, YANG Xinghua, ZHANG Jing, HOU Jie. Early clinical observation of corneal densitometry after SMILE combined with rapid corneal cross-linking [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 52-58.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd